Zobrazeno 1 - 10
of 17
pro vyhledávání: '"A K, Hihi"'
Autor:
Abdelmadjid K. Hihi, Marie-Claude Beauchamp, Robyn Branicky, Annick Desjardins, Isabel Casanova, Marie-Pierre Guimond, Melissa Carroll, Melanie Ethier, Irenej Kianicka, Kevin McBride, Siegfried Hekimi
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 1, Pp 74-83 (2008)
Genetic analysis has shown that the slower than normal rhythmic defecation behavior of the clk-1 mutants of Caenorhabditis elegans is the result of altered lipoprotein metabolism. We show here that this phenotype can be suppressed by drugs that affec
Externí odkaz:
https://doaj.org/article/cf8edad76d314583a3b8faddda8b240e
Autor:
Melissa Carroll, Zaruhi Stepanyan, Marie-Pierre Guimond, Siegfried Hekimi, Ying Wang, Abdelmadjid K. Hihi, Kevin M. McBride, Steve Hayes, Robyn Branicky
Publikováno v:
Journal of Biological Chemistry. 284:314-323
The development of neurodegenerative diseases such as Alzheimer, Parkinson, and Huntington disease is strongly age-dependent. Discovering drugs that act on the high rate of aging in older individuals could be a means of combating these diseases. Redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e459b146ed0d9771dd57252a56b74e71
https://doi.org/10.1074/jbc.m807579200
https://doi.org/10.1074/jbc.m807579200
Autor:
Marie-Pierre Guimond, Melissa Carroll, Kevin M. McBride, Siegfried Hekimi, Marie-Claude Beauchamp, Abdelmadjid K. Hihi, Annick Desjardins, Isabel Casanova, Melanie Ethier, Robyn Branicky, Irenej Kianicka
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 1, Pp 74-83 (2008)
Genetic analysis has shown that the slower than normal rhythmic defecation behavior of the clk-1 mutants of Caenorhabditis elegans is the result of altered lipoprotein metabolism. We show here that this phenotype can be suppressed by drugs that affec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e41dd43001fc5308d569f60000978ee
http://www.sciencedirect.com/science/article/pii/S0022227520428822
http://www.sciencedirect.com/science/article/pii/S0022227520428822
Publikováno v:
Journal of Biological Chemistry. 278:49555-49562
The clk-1 mutants of Caenorhabditis elegans display an average slowing down of physiological rates, including those of development, various behaviors, and aging. clk-1 encodes a hydroxylase involved in the biosynthesis of the redox-active lipid ubiqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12b838e6c38a37a9797b16ff6f6343f
https://doi.org/10.1074/jbc.m308507200
https://doi.org/10.1074/jbc.m308507200
Publikováno v:
Journal of Biological Chemistry. 278:41013-41018
Ubiquinone (coenzyme Q, or Q) is a membrane constituent, whose head group is capable of accepting and donating electrons and whose lipidic side chain is composed of a variable number of isoprene subunits. A possible role for Q as a dietary antioxidan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed56f8237a51919a099912bad219b3f
https://doi.org/10.1074/jbc.m305034200
https://doi.org/10.1074/jbc.m305034200
Publikováno v:
Cellular and Molecular Life Sciences. 59:790-798
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that mediate the effects of fatty acids and their derivatives at the transcriptional level. These receptors stimulate transcription after activation by their cognate li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebbe57c2c9d1778f7bee170f3fcdb290
https://doi.org/10.1007/s00018-002-8467-x
https://doi.org/10.1007/s00018-002-8467-x
Autor:
Shane L. Rea, Jason Burgess, Robyn Branicky, Siegfried Hekimi, Claire Y. Bénard, Abdelmadjid K. Hihi
Publikováno v:
Mechanisms of Ageing and Development. 122:571-594
The nematode Caenorhabditis elegans has become a model system for the study of the genetic basis of aging. In particular, many mutations that extend life span have been identified in this organism. When loss-of-function mutations in a gene lead to li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db415b9b011e838121c59b81e674017e
https://doi.org/10.1016/s0047-6374(01)00218-4
https://doi.org/10.1016/s0047-6374(01)00218-4
Autor:
Pallavi R. Devchand, Wolf-Dieter Schleuning, Abdelmadjid K. Hihi, Bruce M. Spiegelman, Walter Wahli, Mai Perroud
Publikováno v:
Journal of Biological Chemistry. 274:23341-23348
Peroxisome proliferator-activated receptor alpha (PPARalpha)is a nuclear receptor for various fatty acids, eicosanoids, and hypolipidemic drugs. In the presence of ligand, this transcription factor increases expression of target genes that are primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beda1a504d272b7496a4be9470a89fde
https://doi.org/10.1074/jbc.274.33.23341
https://doi.org/10.1074/jbc.274.33.23341
Autor:
Béatrice Desvergne, Manuel Vázquez, Walter Wahli, Taoufik Masmoudi, Yves Artur, Abdelmadjid K. Hihi, Hervé Goudonnet
Publikováno v:
Journal of Biological Chemistry. 272:17171-17175
This study demonstrates that the expression of the phenol UDP-glucuronosyltransferase 1 gene (UGT1A1) is regulated at the transcriptional level by thyroid hormone in rat liver. Following 3,5,3′-triiodo-l-thyronine (T3) stimulation in vivo, there is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7fbd9a65b1dcacb4acce0cdaa66ebe3
https://doi.org/10.1074/jbc.272.27.17171
https://doi.org/10.1074/jbc.272.27.17171
Publikováno v:
Molecular and Cellular Biology. 14:2786-2797
Orphan receptors of the FTZ-F1-related group of nuclear receptors (xFF1r) were identified in Xenopus laevis by isolation of cDNAs from a neurula stage library. Two cDNAs were found, which encode full length, highly related receptor proteins, xFF1rA a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c06a20b7215509cd2f3d1250b2bf0f
https://doi.org/10.1128/mcb.14.4.2786
https://doi.org/10.1128/mcb.14.4.2786