Zobrazeno 1 - 10
of 292
pro vyhledávání: '"A J Tenner"'
Autor:
Nicole D. Schartz, Heidi Y. Liang, Klebea Carvalho, Shu-Hui Chu, Adrian Mendoza-Arvilla, Tiffany J. Petrisko, Angela Gomez-Arboledas, Ali Mortazavi, Andrea J. Tenner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Alzheimer’s disease (AD) is the leading cause of dementia in older adults, and the need for effective, sustainable therapeutic targets is imperative. The complement pathway has been proposed as a therapeutic target. C5aR1 inhibition reduce
Externí odkaz:
https://doaj.org/article/c5d13e6662b4496baed37120ad829da6
Autor:
Tiffany J. Petrisko, Matthew Gargus, Shu-Hui Chu, Purnika Selvan, Katrine L. Whiteson, Andrea J. Tenner
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-16 (2023)
Abstract The contribution of the gut microbiome to neuroinflammation, cognition, and Alzheimer’s disease progression has been highlighted over the past few years. Additionally, inhibition of various components of the complement system has repeatedl
Externí odkaz:
https://doaj.org/article/ec8ea2d255f74df3a4c5afdf98427e7e
Autor:
Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine S. Sakr, Angela Gomez-Arboledas, Miguel A. Arreola, Celia da Cunha, Jimmy Phan, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi, Jonathan Neumann, Ghassan Filimban, Zechuan Shi, Giedre Milinkeviciute, Dominic I. Javonillo, Katelynn Tran, Magdalena Gantuz, Stefania Forner, Vivek Swarup, Andrea J. Tenner, Frank M. LaFerla, Marcelo A. Wood, Ali Mortazavi, Grant R. MacGregor, Kim N. Green
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-26 (2023)
Abstract Background The TREM2 R47H variant is one of the strongest genetic risk factors for late-onset Alzheimer’s Disease (AD). Unfortunately, many current Trem2 R47H mouse models are associated with cryptic mRNA splicing of the mutant allele that
Externí odkaz:
https://doaj.org/article/7cc752a4e65d4dbe841fd116a51289c8
Autor:
Angela Gomez-Arboledas, Klebea Carvalho, Gabriela Balderrama-Gutierrez, Shu-Hui Chu, Heidi Yahan Liang, Nicole D. Schartz, Purnika Selvan, Tiffany J. Petrisko, Miranda A. Pan, Ali Mortazavi, Andrea J. Tenner
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-21 (2022)
Abstract Multiple studies have recognized the involvement of the complement cascade during Alzheimer’s disease pathogenesis. However, the specific role of C5a-C5aR1 signaling in the progression of this neurodegenerative disease is still not clear.
Externí odkaz:
https://doaj.org/article/e8a2e8f8ffde448880a8e769c6b9d008
Autor:
Klebea Carvalho, Nicole D. Schartz, Gabriela Balderrama-Gutierrez, Heidi Y. Liang, Shu-Hui Chu, Purnika Selvan, Angela Gomez-Arboledas, Tiffany J. Petrisko, Maria I. Fonseca, Ali Mortazavi, Andrea J. Tenner
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-21 (2022)
Abstract Background The complement system is part of the innate immune system that clears pathogens and cellular debris. In the healthy brain, complement influences neurodevelopment and neurogenesis, synaptic pruning, clearance of neuronal blebs, rec
Externí odkaz:
https://doaj.org/article/d254ddd8a4eb41ccbf2722299212173b
Autor:
Hai Zhang, Lujia Chen, Kevin G. Johnston, Joshua Crapser, Kim N. Green, Nicole My-Linh Ha, Andrea J. Tenner, Todd C. Holmes, Douglas A. Nitz, Xiangmin Xu
Publikováno v:
Neurobiology of Disease, Vol 176, Iss , Pp 105939- (2023)
A key challenge in developing diagnosis and treatments for Alzheimer's disease (AD) is to detect abnormal network activity at as early a stage as possible. To date, behavioral and neurophysiological investigations in AD model mice have yet to conduct
Externí odkaz:
https://doaj.org/article/94f303bca8164062b3c45e8aa6ad71c0
Autor:
Stefania Forner, Shimako Kawauchi, Gabriela Balderrama-Gutierrez, Enikö A. Kramár, Dina P. Matheos, Jimmy Phan, Dominic I. Javonillo, Kristine M. Tran, Edna Hingco, Celia da Cunha, Narges Rezaie, Joshua A. Alcantara, David Baglietto-Vargas, Camden Jansen, Jonathan Neumann, Marcelo A. Wood, Grant R. MacGregor, Ali Mortazavi, Andrea J. Tenner, Frank M. LaFerla, Kim N. Green
Publikováno v:
Scientific Data, Vol 8, Iss 1, Pp 1-16 (2021)
Measurement(s) Protein Expression • gene expression • electrophysiology data • protein measurement • behavior Technology Type(s) immunofluorescence microscopy assay • RNA sequencing • electrophysiology assay • Electrochemiluminescence I
Externí odkaz:
https://doaj.org/article/b2396bfe67d3413cbec4c74a4d952aef
Autor:
David Baglietto-Vargas, Stefania Forner, Lena Cai, Alessandra C. Martini, Laura Trujillo-Estrada, Vivek Swarup, Marie Minh Thu Nguyen, Kelly Do Huynh, Dominic I. Javonillo, Kristine Minh Tran, Jimmy Phan, Shan Jiang, Enikö A. Kramár, Cristina Nuñez-Diaz, Gabriela Balderrama-Gutierrez, Franklin Garcia, Jessica Childs, Carlos J. Rodriguez-Ortiz, Juan Antonio Garcia-Leon, Masashi Kitazawa, Mohammad Shahnawaz, Dina P. Matheos, Xinyi Ma, Celia Da Cunha, Ken C. Walls, Rahasson R. Ager, Claudio Soto, Antonia Gutierrez, Ines Moreno-Gonzalez, Ali Mortazavi, Andrea J. Tenner, Grant R. MacGregor, Marcelo Wood, Kim N. Green, Frank M. LaFerla
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Most instances of Alzheimer’s disease (AD) are sporadic or not associated with a particular mutation. Here, the authors develop knock-in mice that express wildtype human Aβ under control of the mouse App locus, which may have potential for modelli
Externí odkaz:
https://doaj.org/article/1e311a8bbdd34a96bb987b252f4dfaaf
Autor:
Dominic I. Javonillo, Kristine M. Tran, Jimmy Phan, Edna Hingco, Enikö A. Kramár, Celia da Cunha, Stefania Forner, Shimako Kawauchi, Giedre Milinkeviciute, Angela Gomez-Arboledas, Jonathan Neumann, Crystal E. Banh, Michelle Huynh, Dina P. Matheos, Narges Rezaie, Joshua A. Alcantara, Ali Mortazavi, Marcelo A. Wood, Andrea J. Tenner, Grant R. MacGregor, Kim N. Green, Frank M. LaFerla
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2022)
Animal models of disease are valuable resources for investigating pathogenic mechanisms and potential therapeutic interventions. However, for complex disorders such as Alzheimer’s disease (AD), the generation and availability of innumerous distinct
Externí odkaz:
https://doaj.org/article/677dc4105eff49cab8550eb3df2b59bd
Autor:
Suzanne S. Bohlson, Andrea J. Tenner
Publikováno v:
Annual Review of Immunology. 41:431-452
The complement system is an ancient collection of proteolytic cascades with well-described roles in regulation of innate and adaptive immunity. With the convergence of a revolution in complement-directed clinical therapeutics, the discovery of specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3357635bd2c145013615bc68d79a6045
https://doi.org/10.1146/annurev-immunol-101921-035639
https://doi.org/10.1146/annurev-immunol-101921-035639