Zobrazeno 1 - 10
of 219
pro vyhledávání: '"A J Shatkin"'
Publikováno v:
Public Health in Practice, Vol 6, Iss , Pp 100411- (2023)
Background: Internet overuse is an emerging public health emergency, especially for college students in the United States. The purpose of this study was to assess college students’ internet usage and interest in learning healthy internet usage skil
Externí odkaz:
https://doaj.org/article/478a1776cc8143288e297ddfc3882b31
Publikováno v:
Wiley Interdisciplinary Reviews: RNA. 2:277-298
The 5' mRNA cap structure is essential for efficient gene expression from yeast to human. It plays a critical role in all aspects of the life cycle of an mRNA molecule. Capping occurs co-transcriptionally on the nascent pre-mRNA as it emerges from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e2612d34c5041cc8378ac5c82e9643c
https://doi.org/10.1002/wrna.52
https://doi.org/10.1002/wrna.52
Autor:
Aaron J. Shatkin, Chun Chu
Publikováno v:
Molecular and Cellular Biology. 28:5829-5836
Addition of a 5' cap to RNA polymerase II transcripts, the first step of pre-mRNA processing in eukaryotes from yeasts to mammals, is catalyzed by the sequential action of RNA triphosphatase, guanylyltransferase, and (guanine-N-7)methyltransferase. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4387bc064b3a123efdeec99b2df37d
https://doi.org/10.1128/mcb.00021-08
https://doi.org/10.1128/mcb.00021-08
Publikováno v:
Journal of Biological Chemistry. 283:28010-28019
BMP2 (bone morphogenetic protein 2) is a multifunctional member of the transforming growth factor-β family of growth factors. Disruption of BMP2 signaling results in developmental defects, cancers, and other diseases. BMP2 mRNAs are alternatively po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e033ed57f7ddcc02c33e87f136903f
https://doi.org/10.1074/jbc.m804895200
https://doi.org/10.1074/jbc.m804895200
Autor:
Daniel M. Himmel, William C. Ho, Deena A. Oren, Arthur D. Clark, Stephen H. Hughes, Eddy Arnold, Kalyan Das, Paul L. Boyer, Joseph D. Bauman, Aaron J. Shatkin, Mukta Baweja
Publikováno v:
Nucleic Acids Research
HIV-1 reverse transcriptase (RT) is a primary target for anti-AIDS drugs. Structures of HIV-1 RT, usually determined at approximately 2.5-3.0 A resolution, are important for understanding enzyme function and mechanisms of drug resistance in addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd6af6db5a53c335c549b83d22f4a3c
https://doi.org/10.1093/nar/gkn464
https://doi.org/10.1093/nar/gkn464
Autor:
Kalyan Das, Stephen H. Hughes, Joseph D. Bauman, Eddy Arnold, Aaron J. Shatkin, Arthur D. Clark, Yulia Volovik Frenkel, Paul J. Lewi
Publikováno v:
Proceedings of the National Academy of Sciences. 105:1466-1471
TMC278 is a diarylpyrimidine (DAPY) nonnucleoside reverse transcriptase inhibitor (NNRTI) that is highly effective in treating wild-type and drug-resistant HIV-1 infections in clinical trials at relatively low doses (∼25–75 mg/day). We have deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa57915624591a92123627a301a2113
https://doi.org/10.1073/pnas.0711209105
https://doi.org/10.1073/pnas.0711209105
Publikováno v:
Proceedings of the National Academy of Sciences. 104:17620-17625
Cap formation is the first step of pre-mRNA processing in eukaryotic cells. Immediately after transcription initiation, capping enzyme (CE) is recruited to RNA polymerase II (Pol II) by the phosphorylated carboxyl-terminal domain of the Pol II larges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96fa2eaad9b575482c507d5255efab5
https://doi.org/10.1073/pnas.0708866104
https://doi.org/10.1073/pnas.0708866104
Autor:
Aaron J. Shatkin, James L. Manley
Publikováno v:
Nature Structural Biology. 7:838-842
Nearly all mRNAs are post-transcriptionally modified at their 5' and 3' ends, by capping and polyadenylation, respectively. These essential modifications are of course chemically quite distinct, as are the enzymatic complexes responsible for their sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b170b7d2e6adfde5bc4104fbd3344f9
https://doi.org/10.1038/79583
https://doi.org/10.1038/79583
Publikováno v:
Genomics. 56:217-220
Human p21/SIIR is a novel Ser/Arg/Pro-rich nuclear phosphoprotein that is 48% similar to transcription factor SII and modulates transcription in a promoter context-dependent fashion. We have obtained the complete sequence of TCEAL1, the gene that cod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d8a72443d636ad443901bb934e0461
https://doi.org/10.1006/geno.1998.5705
https://doi.org/10.1006/geno.1998.5705