Zobrazeno 1 - 10
of 514
pro vyhledávání: '"A J Rigby"'
Autor:
Shuling Xu, Zhijun Zhu, Daniel G. Delafield, Michael J. Rigby, Gaoyuan Lu, Megan Braun, Luigi Puglielli, Lingjun Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Dysregulated glycerophospholipid (GP) metabolism in the brain is associated with the progression of neurodegenerative diseases including Alzheimer’s disease (AD). Routine liquid chromatography-mass spectrometry (LC-MS)-based large-scale li
Externí odkaz:
https://doaj.org/article/faba655025324208a9ddfc0c7b1ce66b
Autor:
Reji Babygirija, Michelle M. Sonsalla, Jericha Mill, Isabella James, Jessica H. Han, Cara L. Green, Mariah F. Calubag, Gina Wade, Anna Tobon, John Michael, Michaela M. Trautman, Ryan Matoska, Chung-Yang Yeh, Isaac Grunow, Heidi H. Pak, Michael J. Rigby, Dominique A. Baldwin, Natalie M. Niemi, John M. Denu, Luigi Puglielli, Judith Simcox, Dudley W. Lamming
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Dietary protein is a critical regulator of metabolic health and aging. Low protein diets are associated with healthy aging in humans, and dietary protein restriction extends the lifespan and healthspan of mice. In this study, we examined the
Externí odkaz:
https://doaj.org/article/b26c60924d774ad28f4fa4d30134ac5c
Autor:
Emma L. Beamish, Judith Johnson, Barbara Shih, Rebecca Killick, Frank Dondelinger, Ciarra McGoran, Caitlan Brewster-Craig, Albert Davies, Arnab Bhowmick, Rachael J. Rigby
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTLoop ileostomy is a common surgical procedure to allow downstream tissue healing, with the aim of re-joining the bowel approximately 12 months later. The reversal procedure is associated with a substantial morbidity up to 40%. Our previous re
Externí odkaz:
https://doaj.org/article/e2923fcb9f95431d8fc8975fae7946db
Autor:
Maeghan Murie, Yajing Peng, Michael J. Rigby, Inca A. Dieterich, Mark A. Farrugia, Andreas Endresen, Anita Bhattacharyya, Luigi Puglielli
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Murie et al use in silico docking and affinity binding to identify ATase1 and ATase2 specific inhibitors, and AT1 sTg and APP/PS1 mice to test their translational potential. Their study suggests that ATase-targeting approaches might offer a translati
Externí odkaz:
https://doaj.org/article/33683ef18e5343e5a55dc7a73af44c2a
Autor:
R. Benson, C. Brunsdon, J. Rigby, P. Corcoran, M. Ryan, E. Cassidy, P. Dodd, D. Hennebry, E. Arensman
Publikováno v:
Cambridge Prisms: Global Mental Health, Vol 9, Pp 384-388 (2022)
Suicide mortality rates are a strong indicator of population mental-health and can be used to determine the efficacy of prevention measures. Monitoring suicide mortality rates in real-time provides an evidence-base to inform targeted interventions in
Externí odkaz:
https://doaj.org/article/abfa561bfe274f66891e647baf6893eb
Publikováno v:
Molecular Metabolism, Vol 67, Iss , Pp 101653- (2023)
Background: Key cellular metabolites reflecting the immediate activity of metabolic enzymes as well as the functional metabolic state of intracellular organelles can act as powerful signal regulators to ensure the activation of homeostatic responses.
Externí odkaz:
https://doaj.org/article/8626c29d830f47abab9cc7d627e9b7ec
Autor:
R. Benson, C. Brunsdon, J. Rigby, P. Corcoran, M. Ryan, E. Cassidy, P. Dodd, D. Hennebry, E. Arensman
Publikováno v:
Frontiers in Digital Health, Vol 4 (2022)
Introduction/AimData visualisation is key to informing data-driven decision-making, yet this is an underexplored area of suicide surveillance. By way of enhancing a real-time suicide surveillance system model, an interactive dashboard prototype has b
Externí odkaz:
https://doaj.org/article/2ce0ea94438041b2814a8aad0a266751
Autor:
Mary Ortmayer, Florence J. Hardy, Matthew G. Quesne, Karl Fisher, Colin Levy, Derren J. Heyes, C. Richard A. Catlow, Sam P. de Visser, Stephen E. J. Rigby, Sam Hay, Anthony P. Green
Publikováno v:
JACS Au, Vol 1, Iss 7, Pp 913-918 (2021)
Externí odkaz:
https://doaj.org/article/7b1ea1dfa43042aa99a9e11ae0aa8261
Autor:
Michael J. Rigby, Alexis J. Lawton, Gulpreet Kaur, Varuna C. Banduseela, William E. Kamm, Aparna Lakkaraju, John M. Denu, Luigi Puglielli
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Rigby et al. use transgenic mice that are deficient in the endoplasmic reticulum acetyltransferases Atase1 or Atase2 to demonstrate the differential role of these enzymes in the regulation of reticulophagy and macroautophagy. Their study emphasizes A
Externí odkaz:
https://doaj.org/article/66edeebf23cd4de3a63d2711efd2742c
Autor:
Stephen A. Marshall, Karl A. P. Payne, Karl Fisher, Mark D. White, Aisling Ní Cheallaigh, Arune Balaikaite, Stephen E. J. Rigby, David Leys
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The UbiD-UbiX decarboxylase system is required for the biosynthesis of quinone cofactors. Here, the authors combine structural and biochemical analyses to elucidate the UbiX reaction mechanism, showing that it resembles the mode of action of class I
Externí odkaz:
https://doaj.org/article/7d6536e8acd943bea50c5023037c7730