Zobrazeno 1 - 10
of 34
pro vyhledávání: '"A J McNevin"'
Autor:
Rishi Ramesh, Sutthilug Sotthivirat, Chad D. Brown, Binfeng Xia, Cory Bottone, Walter Wasylaschuk, Joyce Stellabott, Daniel Skomski, Michael J. McNevin
Publikováno v:
Powder Technology. 375:302-309
d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) has been widely used in a variety of oral applications to enhance dissolution, solubility, and/or bioavailability of poorly-water soluble drugs. In addition, the use of TPGS could potentially
Publikováno v:
Analytical Chemistry. 91:6217-6224
High-resolution solid-state analysis of multicomponent molecular systems, e.g., pharmaceutical formulations, is a great challenge. Solid-state nuclear magnetic resonance (ssNMR) spectroscopy plays a critical role in the characterization of solid dosa
Autor:
Xingyu Lu, Haichen Nie, Michael J. McNevin, Wei Xu, Yongchao Su, Gregory M. Troup, Mingyue Li
Publikováno v:
Journal of pharmaceutical sciences. 109(10)
Probing form conversions of active pharmaceutical ingredients in solid dosages is critical for understanding the physicochemical stability of drug substances in formulations. The multicomponent and low drug loading nature of drug products often resul
Autor:
David Harris, Michael J. McNevin, Yung-Chi Lee, Logan Howell, Justin Moser, Georgia Chouzouri, Craig Ikeda
Publikováno v:
AAPS PharmSciTech. 20
A feasibility evaluation of the addition of fumed silica (SiO2) into an agitated dryer to aid spray-dried solid dispersion intermediate (SDSDi) flow during secondary drying and discharge is described. The quantity of SiO2 to enhance the flow characte
Autor:
Celeste Frankenfeld, Narayan Variankaval, Michael J. McNevin, Matthew S. Lamm, Amanda Simpson, Richard Nay
Publikováno v:
Molecular Pharmaceutics. 9:3396-3402
Amorphous solid dispersions of clotrimazole in the polymer Kollidon VA64 were prepared as films in concentrations from 0% to 100% in 10% by weight increments. Nanoindentation was performed on each film at 18% and 49% relative humidity to assess the e
Publikováno v:
Organometallics. 27:1948-1953
Solid-phase structural data for five Zn enolate derivatives are presented. Included are the amide enolates BrZn[CH2C(O)NEt2](thf) (1a), BrZn[CH2C(O)NEt2](dmso) (1b), and BrZn[CH2C(O)NEt2](tBu-py) (...
Autor:
Richard K. Shoemaker, M. Rakowski DuBois, Michael J. McNevin, George M. Jacobsen, Daniel L. DuBois
Publikováno v:
Organometallics. 26:5003-5009
A series of new iron(II) complexes that contain cyclic diphosphine ligands with pendant amine bases, P2RN2R‘, have been synthesized and characterized (where P2RN2R‘ are substituted 1,5-diaza-3,7-diphosphacyclooctanes). These compounds include [Fe
Publikováno v:
Langmuir. 23:7923-7927
An amphiphilic photoisomerizable macrocycle has been prepared that forms stable Langmuir monolayers at the air-water interface. The hydrophilic core of the molecule switches between closed and open isomers upon irradiation by the appropriate waveleng
Publikováno v:
Organometallics. 24:5167-5171
A new chiral bis(β-amino alcohol) ligand, LH 2 , has been prepared in 40% yield by the Cu-catalyzed coupling of 4,6-diiododibenzofuran with diphenylpyrrolidin-2-yl-methanol, the latter of which is prepared from L-proline. The protonolysis reaction o
Autor:
Michael J. McNevin, John R. Hagadorn
Publikováno v:
Inorganic Chemistry. 43:8547-8554
Four different dianionic bis(amidinate) ligands ((iPr)L(DBF)(2)(-), (tBu,Et)L(DBF)(2)(-), (iPr)L(Xan)(2)(-), (tBu,Et)L(Xan)(2)(-)) featuring rigid dibenzofuran (DBF) and 9,9-dimethylxanthene (Xan) backbones have been used to prepare several new ditit