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Akademický článek

The genetics and epidemiology of N- and O-immunoglobulin A glycomics

Autor: Alessia Visconti, Niccolò Rossi, Albert Bondt, Agnes Hipgrave Ederveen, Gaurav Thareja, Carolien A. M. Koeleman, Nisha Stephan, Anna Halama, Hannah J. Lomax-Browne, Matthew C. Pickering, Xu-jie Zhou, Manfred Wuhrer, Karsten Suhre, Mario Falchi

Publikováno v: Genome Medicine, Vol 16, Iss 1, Pp 1-15 (2024)

Abstract Background Immunoglobulin (Ig) glycosylation modulates the immune response and plays a critical role in ageing and diseases. Studies have mainly focused on IgG glycosylation, and little is known about the genetics and epidemiology of IgA gly

Externí odkaz: https://doaj.org/article/ecaa1900ce4c4ce1bc7ee82e4afe3d17

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Akademický článek

Optically stimulated luminescence dosimeters for simultaneous measurement of point dose and dose-weighted LET in an adaptive proton therapy workflow

Autor: Mislav Bobić, Jeppe B. Christensen, Hoyeon Lee, Evangelia Choulilitsa, Katarzyna Czerska, Michele Togno, Sairos Safai, Eduardo G. Yukihara, Brian A. Winey, Antony J. Lomax, Harald Paganetti, Francesca Albertini, Konrad P. Nesteruk

Publikováno v: Frontiers in Oncology, Vol 13 (2024)

PurposeTo demonstrate the suitability of optically stimulated luminescence detectors (OSLDs) for accurate simultaneous measurement of the absolute point dose and dose-weighted linear energy transfer (LETD) in an anthropomorphic phantom for experiment

Externí odkaz: https://doaj.org/article/ce5820e2fadb44be8f99e712f118edd4

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Akademický článek

Automatic lung segmentation of magnetic resonance images: A new approach applied to healthy volunteers undergoing enhanced Deep-Inspiration-Breath-Hold for motion-mitigated 4D proton therapy of lung tumors

Autor: John H. Missimer, Frank Emert, Antony J. Lomax, Damien C. Weber

Publikováno v: Physics and Imaging in Radiation Oncology, Vol 29, Iss , Pp 100531- (2024)

Background and purpose: Respiratory suppression techniques represent an effective motion mitigation strategy for 4D-irradiation of lung tumors with protons. A magnetic resonance imaging (MRI)-based study applied and analyzed methods for this purpose,

Externí odkaz: https://doaj.org/article/69d9ace8fa3540ac936fac31565cdc76

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Akademický článek

Ethical, legal and social aspects of human cerebral organoids and their governance in Germany, the United Kingdom and the United States

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Human cerebral organoids (HCOs) are model systems that enable researchers to investigate the human brain in ways that had previously been impossible. The emergence of HCOs was accompanied by both expert and layperson discussions concerning the possib

Externí odkaz: https://doaj.org/article/6c46c846408045f394793ae21abf3660

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Akademický článek

Large anatomical changes in head-and-neck cancers – A dosimetric comparison of online and offline adaptive proton therapy

Autor: Mislav Bobić, Arthur Lalonde, Konrad P. Nesteruk, Hoyeon Lee, Lena Nenoff, Bram L. Gorissen, Alejandro Bertolet, Paul M. Busse, Annie W. Chan, Brian A. Winey, Gregory C. Sharp, Joost M. Verburg, Antony J. Lomax, Harald Paganetti

Publikováno v: Clinical and Translational Radiation Oncology, Vol 40, Iss , Pp 100625- (2023)

Purpose: This work evaluates an online adaptive (OA) workflow for head-and-neck (H&N) intensity-modulated proton therapy (IMPT) and compares it with full offline replanning (FOR) in patients with large anatomical changes. Methods: IMPT treatment plan

Externí odkaz: https://doaj.org/article/647f303ef76648b6a2847d7b8bffa2e4

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Akademický článek

Commissioning and quality assurance of a novel solution for respiratory-gated PBS proton therapy based on optical tracking of surface markers

Autor: Giovanni Fattori, Jan Hrbacek, Harald Regele, Christian Bula, Alexandre Mayor, Stefan Danuser, David C. Oxley, Urs Rechsteiner, Martin Grossmann, Riccardo Via, Till T. Böhlen, Alessandra Bolsi, Marc Walser, Michele Togno, Emma Colvill, Daniel Lempen, Damien C. Weber, Antony J. Lomax, Sairos Safai

Publikováno v: Zeitschrift für Medizinische Physik, Vol 32, Iss 1, Pp 52-62 (2022)

We present the commissioning and quality assurance of our clinical protocol for respiratory gating in pencil beam scanning proton therapy for cancer patients with moving targets. In a novel approach, optical tracking has been integrated in the therap

Externí odkaz: https://doaj.org/article/6fb1056d27fc4ad6897fb5c0effd82ca

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Akademický článek

The μDose system: determination of environmental dose rates by combined alpha and beta counting – performance tests and practical experiences

Autor: T. Kolb, K. Tudyka, A. Kadereit, J. Lomax, G. Poręba, A. Zander, L. Zipf, M. Fuchs

Publikováno v: Geochronology, Vol 4, Pp 1-31 (2022)

The μDose system is a recently developed analytical instrument applying a combined α- and β-sensitive scintillation technique for determining the radioactivity arising from the decay chains of 235U, 238U and 232Th as well as from the decay of 40K.

Externí odkaz: https://doaj.org/article/6df1fc9bd66f43db80f90e2c1c4b09f5

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