Zobrazeno 1 - 10
of 443
pro vyhledávání: '"A J Isaacs"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Technologies that generate precise combinatorial genome modifications are well suited to dissect the polygenic basis of complex phenotypes and engineer synthetic genomes. Genome modifications with engineered nucleases can lead to undesirable
Externí odkaz:
https://doaj.org/article/55dfb881cd854bf78e3bfa44d467b647
Autor:
Daniel Mark Shapiro, Gunasheil Mandava, Sibel Ebru Yalcin, Pol Arranz-Gibert, Peter J. Dahl, Catharine Shipps, Yangqi Gu, Vishok Srikanth, Aldo I. Salazar-Morales, J. Patrick O’Brien, Koen Vanderschuren, Dennis Vu, Victor S. Batista, Nikhil S. Malvankar, Farren J. Isaacs
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Bacterial hairs called pili become highly-conductive electric wires upon addition of both natural and synthetic amino acids conjugated with gold nanoparticles. Here the authors use computationally-guided ordering further increasing their conductivity
Externí odkaz:
https://doaj.org/article/abb6e2e28250421aabcc8f1954d83d36
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Genome editing methods are limited by the inability to selectively edit repetitive sequences. Here the authors demonstrate precise editing of a repetitive genetic element, a ribosome, while avoiding edits to native sites sharing identical sequence.
Externí odkaz:
https://doaj.org/article/87cbc3f17c704322b10da292b51f9fd2
Autor:
Ali R. Zomorrodi, Colin Hemez, Pol Arranz-Gibert, Terrence Wu, Farren J. Isaacs, Daniel Segrè
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104562- (2022)
Summary: Introducing heterologous pathways into host cells constitutes a promising strategy for synthesizing nonstandard amino acids (nsAAs) to enable the production of proteins with expanded chemistries. However, this strategy has proven challenging
Externí odkaz:
https://doaj.org/article/3dacac0bdcd745f69c3189ebbd410910
Autor:
Rey W. Martin, Benjamin J. Des Soye, Yong-Chan Kwon, Jennifer Kay, Roderick G. Davis, Paul M. Thomas, Natalia I. Majewska, Cindy X. Chen, Ryan D. Marcum, Mary Grace Weiss, Ashleigh E. Stoddart, Miriam Amiram, Arnaz K. Ranji Charna, Jaymin R. Patel, Farren J. Isaacs, Neil L. Kelleher, Seok Hoon Hong, Michael C. Jewett
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Cell-free protein synthesis allows for producing proteins without the need of a host organism, thus sparing the researcher experimental hassle. Here, the authors developed a cell-free synthesis method that enables incorporating non-standard amino aci
Externí odkaz:
https://doaj.org/article/48f02766cbcf45fab8fa2795bb729a58
Autor:
Michael H. Karasick, Carolina Betancourt, Stephanie Dormesy, Jackie Sheehy, Rawlinson J. Isaacs, Bruce S. Sachais, Patricia A. Shi
Publikováno v:
Transfusion. 63:13-22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de8f46e1c408200c047034071a94cc44
https://doi.org/10.1111/trf.17143
https://doi.org/10.1111/trf.17143
Autor:
Erica Lazarus, Kennedy Otwombe, Janan Dietrich, Michele P. Andrasik, Cecilia A. Morgan, James G. Kublin, Glenda E. Gray, Abby J. Isaacs, Fatima Laher
Publikováno v:
Southern African Journal of HIV Medicine, Vol 20, Iss 1, Pp e1-e7 (2019)
Background: Vaginal practices (VP) may adversely affect normal vaginal flora and mucosal integrity, and increase acquisition risk of HIV and other genital tract infections. Objective: The aim of this study was to describe self-reported VP, changes i
Externí odkaz:
https://doaj.org/article/29498c9d0cd14cce9149b1b882b6e6d7
Fitness landscapes are models of the sequence space of a genetic element that map how each sequence corresponds to its activity and can be used to guide laboratory evolution. The ribosome is a macromolecular machine that is essential for protein synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4f28e13cadf298402650f47d3cf55b
Autor:
Luke Invernizzi, Phanankosi Moyo, Joel Cassel, Freddie J. Isaacs, Joseph M. Salvino, Luis J. Montaner, Ian Tietjen, Vinesh Maharaj
Publikováno v:
Analytical and Bioanalytical Chemistry. 414:3971-3985
SARS-CoV-2, the causative agent of COVID-19, continues to cause global morbidity and mortality despite the increasing availability of vaccines. Alongside vaccines, antivirals are urgently needed to combat SARS-CoV-2 infection and spread, particularly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3d28c70b6a9a96adb82473d2fb0bf0
https://doi.org/10.1007/s00216-022-04041-3
https://doi.org/10.1007/s00216-022-04041-3
Autor:
Tufia C. Haddad, Vera J. Suman, Antonino B. D’Assoro, Jodi M. Carter, Karthik V. Giridhar, Brendan P. McMenomy, Katelyn Santo, Erica L. Mayer, Meghan S. Karuturi, Aki Morikawa, P. Kelly Marcom, Claudine J. Isaacs, Sun Young Oh, Amy S. Clark, Ingrid A. Mayer, Khandan Keyomarsi, Timothy J. Hobday, Prema P. Peethambaram, Ciara C. O’Sullivan, Roberto A. Leon-Ferre, Minetta C. Liu, James N. Ingle, Matthew P. Goetz
Publikováno v:
JAMA Oncology.
ImportanceAurora A kinase (AURKA) activation, related in part to AURKA amplification and variants, is associated with downregulation of estrogen receptor (ER) α expression, endocrine resistance, and implicated in cyclin-dependent kinase 4/6 inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d21993adc2114a57d576180b76ce52d1
https://doi.org/10.1001/jamaoncol.2022.7949
https://doi.org/10.1001/jamaoncol.2022.7949