Zobrazeno 1 - 10
of 557
pro vyhledávání: '"A J Deans"'
Autor:
Katherine C. Bergus, MD, MPH, Carley Lutz, BS, Jennifer Cooper, PhD, Lindsey Asti, PhD, MPH, Lindsay Gil, MD, MPH, Cory Criss, MD, Katherine J. Deans, MD, MHSc, Peter C. Minneci, MD, MHSc
Publikováno v:
Annals of Surgery Open, Vol 5, Iss 3, p e488 (2024)
Objective:. To investigate the heterogeneity of treatment effects (HTE) of laser epilation in preventing pilonidal disease recurrence through analysis of prespecified clinical factors. Background:. Pilonidal disease is a common, painful disease affec
Externí odkaz:
https://doaj.org/article/c1e777072b3f407a94ebe201bd6be277
Autor:
Sile F. Yang, Christopher B. Nelson, Jadon K. Wells, Madushan Fernando, Robert Lu, Joshua A. M. Allen, Lisa Malloy, Noa Lamm, Vincent J. Murphy, Joel P. Mackay, Andrew J. Deans, Anthony J. Cesare, Alexander P. Sobinoff, Hilda A. Pickett
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during DNA damage and repair, and as a part of the replication stress response. Here, we ident
Externí odkaz:
https://doaj.org/article/a2cf012d392f4eca877ee8790143a0a5
Autor:
Christina Georgeades, Amelia T. Collings, Manzur Farazi, Carisa Bergner, Mary E. Fallat, Peter C. Minneci, K. Elizabeth Speck, Kyle J. Van Arendonk, Katherine J. Deans, Richard A. Falcone, David S. Foley, Jason D. Fraser, Samir K. Gadepalli, Martin S. Keller, Meera Kotagal, Matthew P. Landman, Charles M. Leys, Troy A. Markel, Nathan S. Rubalcava, Shawn D. St. Peter, Thomas T. Sato, Katherine T. Flynn-O’Brien, the Midwest Pediatric Surgery Consortium (MWPSC)
Publikováno v:
Injury Epidemiology, Vol 10, Iss S1, Pp 1-10 (2023)
Abstract Background The COVID-19 pandemic disrupted social, political, and economic life across the world, shining a light on the vulnerability of many communities. The objective of this study was to assess injury patterns before and after implementa
Externí odkaz:
https://doaj.org/article/b7a748de91944a6db0e3cc7fda339804
Autor:
Muhammad Ishaq, Duyen Tran, Cheng Yang, Min Jia Ng, Arlene Kackanattil, Karthik Tata, Bianca J. Deans, Martin Bleasel, Silvia Vicenzi, Cameron Randall, Tauseef Ahmad, Carmelo Vicario, Maurizio Ronci, Mariachiara Zuccarini, Renata Ciccarelli, Paul Scowen, Dinesh Kumar Chellappan, Glenn Jacobson, Alex C. Bissember, Jason A. Smith, Rajaraman Eri, Juan J. Canales, Miguel Iglesias, Nuri Guven, Vanni Caruso
Publikováno v:
Endocrines, Vol 3, Iss 4, Pp 641-653 (2022)
Obesity produces a systemic low-grade inflammation associated with many adverse health conditions and, as we recently learned, with complications of COVID-19. Functional studies in animal models have demonstrated that asperuloside, an iridoid glycosi
Externí odkaz:
https://doaj.org/article/0c2bc3f7ac8942a488605278c3e78f17
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-3 (2021)
FANCM protein truncating variants (PTVs) are emerging as risk factors for ER-negative and triple negative breast cancer. Here, we discuss evidence that greatest risk associates with PTVs, such as p.Arg658*, that extensively truncate the 2048 amino ac
Externí odkaz:
https://doaj.org/article/104eda8a91d541078387d85e7e6c593d
Autor:
Elaine Sanij, Katherine M. Hannan, Jiachen Xuan, Shunfei Yan, Jessica E. Ahern, Anna S. Trigos, Natalie Brajanovski, Jinbae Son, Keefe T. Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J. Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J. Deans, Kum Kum Khanna, Linda Mileshkin, Grant A. McArthur, John Soong, Els M. J. J. Berns, Ross D. Hannan, Clare L. Scott, Karen E. Sheppard, Richard B. Pearson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Acquired resistance limits the efficacy of PARP inhibitors (PARPi) in high grade serous ovarian cancer (HGSOC). Here, the authors show that inhibition of RNA polymerase I transcription using CX-5461 increases the therapeutic efficacy of PARPi and ove
Externí odkaz:
https://doaj.org/article/e147f3013f3440d1be5ac0b31368773d
Autor:
Katherine J Deans, Peter C Minneci, Kelli Nicole Patterson, Kyle Z Horvath, Rajan Thakkar, LeeAnn Wurster, Dana L Noffsinger, Tran Bourgeois
Publikováno v:
World Journal of Pediatric Surgery, Vol 5, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/fb7c890966f541678c473e1008e232f4
Autor:
Amelia T. Collings, Manzur Farazi, Kyle J. Van Arendonk, Mary E. Fallat, Peter C. Minneci, Thomas T. Sato, K. Elizabeth Speck, Samir Gadepalli, Katherine J. Deans, Richard A. Falcone, David S. Foley, Jason D. Fraser, Martin S. Keller, Meera Kotagal, Matthew P. Landman, Charles M. Leys, Troy Markel, Nathan Rubalcava, Shawn D. St. Peter, Katherine T. Flynn-O’Brien
Publikováno v:
Journal of Surgical Research. 289:61-68
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a78e7abe7faa8df3155768976efc99e9
https://doi.org/10.1016/j.jss.2023.03.003
https://doi.org/10.1016/j.jss.2023.03.003
Autor:
Bruno Silva, Richard Pentz, Ana Margarida Figueira, Rajika Arora, Yong Woo Lee, Charlotte Hodson, Harry Wischnewski, Andrew J. Deans, Claus M. Azzalin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
In cancer cells, telomeres can be elongated through homology directed-repair pathways in a process known as Alternative Lengthening of Telomeres (ALT). Here, the authors reveal that FANCM regulates ALT activity and ALT cell proliferation by limiting
Externí odkaz:
https://doaj.org/article/288a7c4d17534c13992012134d9710a4
Autor:
Robert Lu, Julienne J. O’Rourke, Alexander P. Sobinoff, Joshua A. M. Allen, Christopher B. Nelson, Christopher G. Tomlinson, Michael Lee, Roger R. Reddel, Andrew J. Deans, Hilda A. Pickett
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
ALT telomeres experience DNA damage that may drive recombination-based telomere elongation. Here, the authors reveal that FANCM plays a critical role in the suppression of ALT activity through its interaction with the BTR (BLM-TOP3A-RMI) complex.
Externí odkaz:
https://doaj.org/article/ec5006d7bd3c48149838ce39d9f207f5