Zobrazeno 1 - 10
of 71
pro vyhledávání: '"A J Crottogini"'
Autor:
Cristian N. Nuñez Pedrozo, Tomás M. Peralta, Fernanda D. Olea, Paola Locatelli, Alberto J. Crottogini, Mariano N. Belaich, Luis A. Cuniberti
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 3779-3782 (2022)
Angiogenic gene overexpression has been the main strategy in numerous vascular regenerative gene therapy projects. However, most have failed in clinical trials. CRISPRa technology enhances gene overexpression levels based on the identification of sgR
Externí odkaz:
https://doaj.org/article/b1ac9b80f2f04506b2243b71d3572e3c
Autor:
Martha G Castillo, Tomás M Peralta, Paola Locatelli, Candela Velazquez, Yamila Herrero, Alberto J Crottogini, Fernanda D Olea, Luis A Cuniberti
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0277442 (2023)
BackgroundRecent preclinical studies have demonstrated that bone marrow (BM)-derived Muse cells have a homing mechanism to reach damaged cardiac tissue while also being able to reduce myocardial infarct size and improve cardiac function; however, the
Externí odkaz:
https://doaj.org/article/53bcd91f8556482299da07239924e8ce
Autor:
Luis Cuniberti, Ayelén E. López, Fernanda Daniela Olea, Maria del Rosario Bauza, Paola Locatelli, Alberto J. Crottogini
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:346-360
Adult mammalian cardiomyocytes show scarce division ability, which makes the heart ineffective in replacing lost contractile cells after ischemic cardiomyopathy. In the past decades, there have been increasing efforts in the search for novel strategi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8866fd9b23be7598d1b1b8eee04ec8f3
https://doi.org/10.1097/fjc.0000000000001072
https://doi.org/10.1097/fjc.0000000000001072
Autor:
Mariano Nicolás Belaich, Carlos Sebastián Giménez, Jorge Alejandro Simonin, Ayelén E. López, Natalia Pascuali, Paola Locatelli, Luis Cuniberti, Cristian N. Núñez Pedrozo, Martha G. Castillo, Alfredo O. Mendiz, Fernanda Daniela Olea, Maria del Rosario Bauza, Alberto J. Crottogini
Publikováno v:
Cytotherapy. 22:563-572
Peripheral arterial disease (PAD) is a progressive, disabling ailment for which no effective treatment exists. Gene therapy-mediated neovascularization has emerged as a potentially useful strategy. We tested the angiogenic and arteriogenic efficacy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2983d7b9c6c86b77f54393a37e6a1ff1
https://doi.org/10.1016/j.jcyt.2020.06.010
https://doi.org/10.1016/j.jcyt.2020.06.010
Autor:
Marta G. Castillo, Carlos Sebastián Giménez, Pablo Daniel Ghiringhelli, Luis Cuniberti, Alberto J. Crottogini, Jorge Alejandro Simonin, Carolina Susana Cerrudo, Ayelén E. López, Paola Locatelli, Martin Uranga Vega, Fernanda Daniela Olea, Maria del Rosario Bauza, Mariano Nicolás Belaich
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
The adult mammalian cardiomyocyte has a very limited capacity to reenter the cell cycle and advance into mitosis. Therefore, diseases characterized by lost contractile tissue usually evolve into myocardial remodeling and heart failure. Analyzing the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b577dcca6d24604477d624b51a0e52
https://pubmed.ncbi.nlm.nih.gov/32167779
https://pubmed.ncbi.nlm.nih.gov/32167779
Autor:
Luis Cuniberti, Carlos Sebastián Giménez, Maurizio C. Capogrossi, Andrea De Lorenzi, Anna Hnatiuk, Fernanda Daniela Olea, Maria del Rosario Bauza, Alberto J. Crottogini, Paola Locatelli
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
In rodents with acute myocardial infarction (AMI), high mobility group box 1 (HMGB1) injection has produced controversial results. Given the lack of data in large mammals, we searched the dose that would promote angiogenesis and expression of specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266e1e395b9ed6b994aa9db05d9b59c3
http://link.springer.com/10.1007/s13346-019-00628-z
http://link.springer.com/10.1007/s13346-019-00628-z
Autor:
A.E. Lopez, P. Locatelli, C.S. Gimenez, M.G. Castillo Velasquez, Alberto J. Crottogini, Luis Cuniberti, G. Giunta, D. Olea
Publikováno v:
Atherosclerosis. 315:e239
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84d3d325a550c5c250456df25fd5faba
https://doi.org/10.1016/j.atherosclerosis.2020.10.753
https://doi.org/10.1016/j.atherosclerosis.2020.10.753
Autor:
Luis Cuniberti, Fernanda Daniela Olea, Mario Embon, Maria del Rosario Bauza, Gustavo Abel Abraham, Anna Hnatiuk, Andrea De Lorenzi, Paola Locatelli, Ángela Patricia Neira Sepúlveda, Carlos Sebastián Giménez, Florencia Montini Ballarin, Ricardo A Dewey, Alberto J. Crottogini
Diaphragmatic myoblasts (DM) are stem cells of the diaphragm, a muscle displaying high resistance to stress and exhaustion. We hypothesized that DM modified to overexpress connexin-43 (cx43), seeded on aligned poly (l-lactic acid) (PLLA) sheets would
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110933fc5ebd15a7c23c3e3ff3d5349d
https://www.tandfonline.com/doi/full/10.1080/21691401.2018.1508029
https://www.tandfonline.com/doi/full/10.1080/21691401.2018.1508029
Autor:
Alberto J. Crottogini, Mariano Nicolás Belaich, Paola Locatelli, Carlos Sebastián Giménez, Martin Uranga Vega
Adult mammalian cardiomyocytes (CMs) exhibit limited proliferative capacity, as cell cycle activity leads to an increase in DNA content, but mitosis and cytokinesis are infrequent. This makes the heart highly inefficient in replacing with neoformed c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d8e11ada0e8cce41b011dea851f9dc
http://www.eurekaselect.com/164246/article
http://www.eurekaselect.com/164246/article
Autor:
Anna Hnatiuk, Rubén P. Laguens, Alberto J. Crottogini, A. B. De Lorenzi, M Cerdá, Paola Locatelli, Carlos Sebastián Giménez, Diana Elizabeth Sepúlveda, Fernanda Daniela Olea
Publikováno v:
Gene Therapy. 22:449-457
Mesenchymal stromal cells (MSCs) are cardioprotective in acute myocardial infarction (AMI). Besides, we have shown that intramyocardial injection of plasmid-VEGF165 (pVEGF) in ovine AMI reduces infarct size and improves left ventricular (LV) function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97fa085482834c8b6c6ac22a57ea6697
https://doi.org/10.1038/gt.2015.28
https://doi.org/10.1038/gt.2015.28