Zobrazeno 1 - 10
of 305
pro vyhledávání: '"A J Churchyard"'
Autor:
Akash Malhotra, Bareng Aletta Sanny Nonyane, Evan Shirey, Christiaan Mulder, Piotr Hippner, Fiseha Mulatu, Andani Ratshinanga, Petros Mitiku, Silvia Cohn, Gideon Conradie, Violet Chihota, Richard E. Chaisson, Gavin J. Churchyard, Jonathan Golub, David Dowdy, Hojoon Sohn, Salome Charalambous, Ahmed Bedru, Nicole Salazar-Austin
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background Each year, 1 million children develop TB resulting in over 200,000 child deaths. TB preventive treatment (TPT) is highly effective in preventing TB but remains poorly implemented for household child contacts. Home-based child cont
Externí odkaz:
https://doaj.org/article/74ce00ba6a9548e1ad4213179eac7270
Autor:
Leela R.L. Davies, Malisa T. Smith, Deniz Cizmeci, Stephanie Fischinger, Jessica Shih-Lu Lee, Lenette L. Lu, Erik D. Layton, Alison D. Grant, Katherine Fielding, Catherine M. Stein, W. Henry Boom, Thomas R. Hawn, Sarah M. Fortune, Robert S. Wallis, Gavin J. Churchyard, Galit Alter, Chetan Seshadri
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104678- (2023)
Summary: Background: The prevalence of tuberculosis among men who work in the gold mines of South Africa is among the highest in the world, but a fraction of miners demonstrate consistently negative results upon tuberculin skin test (TST) and IFN-γ
Externí odkaz:
https://doaj.org/article/0c58ca4c3fba49d19ebee7d80aaf7eba
Autor:
Yasmeen Hanifa, Violet N. Chihota, Katherine L. Fielding, Salome Charalambous, Lungiswa Adonis, Alan Karstaedt, Nicola Foster, Mark P. Nicol, Kerrigan McCarthy, Edina Sinanovic, Nontobeko T. Ndlovu, Wendy Stevens, Faieza Sahid, Alison D. Grant, Gavin J. Churchyard, Anna Vassall
Publikováno v:
Gates Open Research, Vol 2 (2022)
Background: Amongst HIV-positive adults in South Africa with initial negative Xpert results, we compared the yield from repeating Xpert MTB/RIF (“Xpert”) on sputum to guideline-recommended investigation for tuberculosis (TB). Methods: A systemati
Externí odkaz:
https://doaj.org/article/6f48f9a6249f47dbac01973353aadfd1
Resistance to Mycobacterium tuberculosis infection among highly TB exposed South African gold miners
Autor:
Violet N. Chihota, Thobani Ntshiqa, Pholo Maenetje, Raoul Mansukhani, Kavindhran Velen, Thomas R. Hawn, Robert Wallis, Alison D. Grant, Gavin J. Churchyard, Katherine Fielding
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Background Despite high exposure to Mycobacterium tuberculosis, a small proportion of South African goldminers resist TB infection. We determined, among long-service gold miners i) the proportion who were TB uninfected and ii) epidemiological factors
Externí odkaz:
https://doaj.org/article/ac91a079a6e042d4a85f5f23b09d3f01
Autor:
Lucy Andere Chimoyi, Christian Lienhardt, Nishila Moodley, Priya Shete, Gavin J Churchyard, Salome Charalambous
Publikováno v:
BMJ Global Health, Vol 5, Iss 7 (2020)
Introduction Tuberculosis (TB) case finding strategies are recommended to increase yield for TB in key populations. Several key populations are identified in the literature, but techniques for estimating yield and prioritising interventions are neede
Externí odkaz:
https://doaj.org/article/a794477b6eb24bd09412054d398d8f88
Autor:
Lucy Chimoyi, Kavindhran Velen, Gavin J Churchyard, Robert Wallis, James J Lewis, Salome Charalambous
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243707 (2020)
As the SARS-CoV2 pandemic has progressed, there have been marked geographical differences in the pace and extent of its spread. We evaluated the association of BCG vaccination on morbidity and mortality of SARS-CoV2, adjusted for country-specific res
Externí odkaz:
https://doaj.org/article/b05e40d64e174245b4438fbf36da772e
Autor:
Stewart T. Chang, Violet N. Chihota, Katherine L. Fielding, Alison D. Grant, Rein M. Houben, Richard G. White, Gavin J. Churchyard, Philip A. Eckhoff, Bradley G. Wagner
Publikováno v:
BMC Medicine, Vol 16, Iss 1, Pp 1-12 (2018)
Abstract Background Gold mines represent a potential hotspot for Mycobacterium tuberculosis (Mtb) transmission and may be exacerbating the tuberculosis (TB) epidemic in South Africa. However, the presence of multiple factors complicates estimation of
Externí odkaz:
https://doaj.org/article/3ea3c4975e4a4cddb693c6aeb550a6f6
Autor:
Gavin J Churchyard, Sue Swindells
Publikováno v:
PLoS Medicine, Vol 16, Iss 4, p e1002787 (2019)
In a Perspective, Gavin Churchyard and Sue Swindells discuss the importance of strategies to target latent tuberculosis infection in high risk populations and thus disrupt a reservoir for new infections in high burden countries.
Externí odkaz:
https://doaj.org/article/aeb01a2326104127975b891d79e201da
Autor:
Ryan T. Jarrett, Yuri van der Heijden, Matthew S. Shotwell, Violet Chihota, Mark A. Marzinke, Richard E. Chaisson, Kelly E. Dooley, Gavin J. Churchyard
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
Isoniazid pharmacokinetics are not yet well-described during once weekly, high-dose administrations with rifapentine (3HP) for latent tuberculosis infection (LTBI). Fewer data describe 3HP with dolutegravir-based antiretroviral therapy for the treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abae817fbf0178e11f380958ce3777c2
https://doi.org/10.1128/aac.01297-22
https://doi.org/10.1128/aac.01297-22
Autor:
Liesl Page-Shipp, James J Lewis, Kavindhran Velen, Sedikanelo Senoge, Elizabeth Zishiri, Flora Popane, Violet N Chihota, Dave Clark, Gavin J Churchyard, Salome Charalambous
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0192089 (2018)
In South Africa, TB household contact tracing provides an opportunity for increased TB and HIV case finding. We aimed to determine the effect of two new potential interventions for TB contact tracing programmes: Point of Care CD4 (PoC CD4) on HIV lin
Externí odkaz:
https://doaj.org/article/d160141c5daf44debc49fcc5f552099b