Zobrazeno 1 - 10
of 26
pro vyhledávání: '"A J Chirino"'
Autor:
Maximiliano J. Chirino
Publikováno v:
Artilugio, Iss 8, Pp 76-89 (2022)
Este trabajo se centra en cuáles son los posibles lugares que pueden tomar las prácticas escénicas en relación a las condiciones adversas que hacen a las formas de vida contemporáneas. Se ensayan posibles respuestas a partir de los aportes reali
Externí odkaz:
https://doaj.org/article/824bb42644fb4be28b699255b714406b
Autor:
Anthony Mire-Sluis, Arthur J. Chirino
Publikováno v:
Nature Biotechnology. 22:1383-1391
Changes in production methods of a biological product may necessitate an assessment of comparability to ensure that these manufacturing changes have not affected the safety, identity, purity, or efficacy of the product. Depending on the nature of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4be606ba45980f5886839b1c6d71f9
https://doi.org/10.1038/nbt1030
https://doi.org/10.1038/nbt1030
Publikováno v:
Drug Discovery Today. 9:82-90
As is cautioned in many package inserts, 'with all therapeutic proteins, there is a potential for immunogenicity'. Immunogenicity problems in humans, which currently can be detected only in clinical trials or after product launch, pose a significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd35a59f5d39afb4fd42ac4253e9a6ae
https://doi.org/10.1016/s1359-6446(03)02953-2
https://doi.org/10.1016/s1359-6446(03)02953-2
Publikováno v:
Drug Discovery Today. 8:212-221
An increasing number of engineered protein therapeutics are currently being developed, tested in clinical trials and marketed for use. Many of these proteins arose out of hit-and-miss efforts to discover specific mutations, fusion partners or chemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928e9c4b02605b41cef2f5f7ebd70d2e
https://doi.org/10.1016/s1359-6446(03)02610-2
https://doi.org/10.1016/s1359-6446(03)02610-2
Autor:
Martina Huber, E.J. Lous, Craig C. Schenck, Douglas C. Rees, Arthur J. Chirino, James P. Allen, George Feher, Mark L. Paddock
Publikováno v:
Biochemistry. 33:4584-4593
Seven site-directed mutants of the bacterial photosynthetic reaction center (RC) from the 2.4.1 and WS 231 wild-type strains of Rhodobacter sphaeroides have been crystallized and their X-ray diffraction analyzed to resolutions between 3.0 and 4.0 A.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3775f736d4df51868cac00d5a6178bb0
https://doi.org/10.1021/bi00181a020
https://doi.org/10.1021/bi00181a020
Autor:
A J, Chirino, A R, Mire-Sluis
Publikováno v:
Developments in biologicals. 122
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54df6efe2e6cee3fde9ffd451a7f4752
https://pubmed.ncbi.nlm.nih.gov/16375248
https://pubmed.ncbi.nlm.nih.gov/16375248
Autor:
Eugene Zhukovsky, Araz Eivazi, Alice Kim, Lisa Cherry, Omid Vafa, Peter Cheung, Jost Vielmetter, Paul Michael Steed, Sandhya Kashi, Arthur J. Chirino, Jonathan Zalevsky, John R. Desjarlais, Linus Hyun, Marian Hwang, Christina Abbott, Rend S. Hubert, Esther Kim, David E. Szymkowski, Sarah X. Gao, C. O'Brien, James Kung, Hyo H. Chung, Malú G. Tansey, Donald O'keefe, Sean Yoder, Stephen K. Doberstein, David F. Carmichael, Karen Singer, Anton Filikov, T. Umesh S. Muchhal, Duc-Hanh T. Nguyen, Cheryl Chan, Sabrina P. Martinez, Bassil I. Dahiyat
Publikováno v:
Science (New York, N.Y.). 301(5641)
Tumor necrosis factor (TNF) is a key regulator of inflammatory responses and has been implicated in many pathological conditions. We used structure-based design to engineer variant TNF proteins that rapidly form heterotrimers with native TNF to give
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde7bbe8096068d11314ae2a672bda88
https://pubmed.ncbi.nlm.nih.gov/14512626
https://pubmed.ncbi.nlm.nih.gov/14512626
Autor:
Ten Feizi, Ziva Misulovin, Arthur J. Chirino, Pamela J. Bjorkman, Yang Liu, Michel C. Nussenzweig, Christine Leteux
Publikováno v:
The Journal of Experimental Medicine
The macrophage and epithelial cell mannose receptor (MR) binds carbohydrates on foreign and host molecules. Two portions of MR recognize carbohydrates: tandemly arranged C-type lectin domains facilitate carbohydrate-dependent macrophage uptake of inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7bc413bfa20733a2d03e0be75718dd
https://pubmed.ncbi.nlm.nih.gov/10748229
https://pubmed.ncbi.nlm.nih.gov/10748229
Autor:
Pamela J. Bjorkman, Arthur J. Chirino
Zn-alpha 2-glycoprotein (ZAG) is a 41 kDa soluble protein whose sequence and domain organization are surprisingly similar to those of the membrane glycoproteins of the major histocompatibility complex (MHC). MHC molecules function in the presentation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e94d537cc9773aa79db0ac2933ddf0b
https://doi.org/10.21236/ada383017
https://doi.org/10.21236/ada383017
