To 200,000 m/z and Beyond: Native Electron Capture Charge Reduction Mass Spectrometry Deconvolves Heterogeneous Signals in Large Biopharmaceutical Analytes

Autor: Kyle I. P. Le Huray, Tobias P. Wörner, Tiago Moreira, Marcin Dembek, Maria Reinhardt-Szyba, Paul W. A. Devine, Nicholas J. Bond, Kyle L. Fort, Alexander A. Makarov, Frank Sobott

Publikováno v: ACS Central Science, Vol 10, Iss 8, Pp 1548-1561 (2024)

Externí odkaz: https://doaj.org/article/9e01e0a42ddf4a35ab49ce43b62575e8

The impact of low-mode symmetry on inertial fusion energy output in the burning plasma state

Autor: J. E. Ralph, J. S. Ross, A. B. Zylstra, A. L. Kritcher, H. F. Robey, C. V. Young, O. A. Hurricane, A. Pak, D. A. Callahan, K. L. Baker, D. T. Casey, T. Döppner, L. Divol, M. Hohenberger, S. Le Pape, P. K. Patel, R. Tommasini, S. J. Ali, P. A. Amendt, L. J. Atherton, B. Bachmann, D. Bailey, L. R. Benedetti, L. Berzak Hopkins, R. Betti, S. D. Bhandarkar, J. Biener, R. M. Bionta, N. W. Birge, E. J. Bond, D. K. Bradley, T. Braun, T. M. Briggs, M. W. Bruhn, P. M. Celliers, B. Chang, T. Chapman, H. Chen, C. Choate, A. R. Christopherson, D. S. Clark, J. W. Crippen, E. L. Dewald, T. R. Dittrich, M. J. Edwards, W. A. Farmer, J. E. Field, D. Fittinghoff, J. Frenje, J. Gaffney, M. Gatu Johnson, S. H. Glenzer, G. P. Grim, S. Haan, K. D. Hahn, G. N. Hall, B. A. Hammel, J. Harte, E. Hartouni, J. E. Heebner, V. J. Hernandez, H. W. Herrmann, M. C. Herrmann, D. E. Hinkel, D. D. Ho, J. P. Holder, W. W. Hsing, H. Huang, K. D. Humbird, N. Izumi, L. C. Jarrott, J. Jeet, O. Jones, G. D. Kerbel, S. M. Kerr, S. F. Khan, J. Kilkenny, Y. Kim, H. Geppert-Kleinrath, V. Geppert-Kleinrath, C. Kong, J. M. Koning, J. J. Kroll, M. K. G. Kruse, B. Kustowski, O. L. Landen, S. Langer, D. Larson, N. C. Lemos, J. D. Lindl, T. Ma, M. J. MacDonald, B. J. MacGowan, A. J. Mackinnon, S. A. MacLaren, A. G. MacPhee, M. M. Marinak, D. A. Mariscal, E. V. Marley, L. Masse, K. D. Meaney, N. B. Meezan, P. A. Michel, M. Millot, J. L. Milovich, J. D. Moody, A. S. Moore, J. W. Morton, T. J. Murphy, K. Newman, J.-M. G. Di Nicola, A. Nikroo, R. Nora, M. V. Patel, L. J. Pelz, J. L. Peterson, Y. Ping, B. B. Pollock, M. Ratledge, N. G. Rice, H. G. Rinderknecht, M. Rosen, M. S. Rubery, J. D. Salmonson, J. Sater, S. Schiaffino, D. J. Schlossberg, M. B. Schneider, C. R. Schroeder, H. A. Scott, S. M. Sepke, K. Sequoia, M. W. Sherlock, S. Shin, V. A. Smalyuk, B. K. Spears, P. T. Springer, M. Stadermann, S. Stoupin, D. J. Strozzi, L. J. Suter, C. A. Thomas, R. P. J. Town, C. Trosseille, E. R. Tubman, P. L. Volegov, C. R. Weber, K. Widmann, C. Wild, C. H. Wilde, B. M. Van Wonterghem, D. T. Woods, B. N. Woodworth, M. Yamaguchi, S. T. Yang, G. B. Zimmerman

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Indirect Drive Inertial Confinement Fusion Experiments on the National Ignition Facility (NIF) have achieved a burning plasma state with neutron yields exceeding 170 kJ, roughly 3 times the prior record and a necessary stage for igniting pla

Externí odkaz: https://doaj.org/article/269b30b0fbbf4e519e1e759f9f698844

Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder

Autor: Nicolas A. Nuñez, Brandon J. Coombes, Lindsay Melhuish Beaupre, Aysegul Ozerdem, Manuel Gardea Resendez, Francisco Romo-Nava, David J. Bond, Marin Veldic, Balwinder Singh, Katherine M. Moore, Hannah K. Betcher, Simon Kung, Miguel L. Prieto, Manuel Fuentes, Mete Ercis, Alessandro Miola, Jorge A. Sanchez Ruiz, Gregory Jenkins, Anthony Batzler, Jonathan G. Leung, Alfredo Cuellar-Barboza, Susannah J. Tye, Susan L. McElroy, Joanna M. Biernacka, Mark A. Frye

Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-5 (2024)

Abstract There is increasing interest in individualizing treatment selection for more than 25 regulatory approved treatments for major depressive disorder (MDD). Despite an inconclusive efficacy evidence base, antidepressants (ADs) are prescribed for

Externí odkaz: https://doaj.org/article/30895815cfaa4cdd8a949170cc6615ae

A sensitive method to determine 210Po and 210Pb in environmental samples by alpha spectrometry using CuS micro-precipitation

Autor: Stephanie Walsh, Matthew J. Bond, Nicolas Guérin, Jules M. Blais, David J. Rowan

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract A new sensitive method to determine polonium-210 (210Po) and lead-210 (210Pb) in a diversity of environmental samples was developed. For fresh and marine waters, Po was pre-concentrated using a titanium (III) hydroxide (Ti(OH)3) co-precipita

Externí odkaz: https://doaj.org/article/5d65804a569b4a6da4d7adf1f40e0e89

Membrane platform protein PulF of the Klebsiella type II secretion system forms a trimeric ion channel essential for endopilus assembly and protein secretion

Autor: Ingrid Guilvout, Firdaus Samsudin, Roland G. Huber, Peter J. Bond, Benjamin Bardiaux, Olivera Francetic

Publikováno v: mBio, Vol 15, Iss 1 (2024)

ABSTRACTType IV pili and type II secretion systems (T2SS) are crucial for bacterial adaptation, virulence, and environmental impact. A common mechanism underlying their multiple functions involves assembly of dynamic plasma membrane-anchored filament

Externí odkaz: https://doaj.org/article/7a103344dae54b51a66c69c9793fba99