Zobrazeno 1 - 10
of 893
pro vyhledávání: '"A J, van Wijnen"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Within the scope of this investigation, we carried out experiments to investigate the potential of the Vision Transformer (ViT) in the field of medical image analysis. The diagnosis of osteoporosis through inspection of X-ray radio-images is
Externí odkaz:
https://doaj.org/article/579aa75fdee5452984d74e38effe703d
Autor:
Alfonso Eirin, Roman Thaler, Logan M. Glasstetter, Li Xing, Xiang-Yang Zhu, Andrew C. Osborne, Ronscardy Mondesir, Aditya V. Bhagwate, Amir Lerman, Andre J. van Wijnen, Lilach O. Lerman
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-11 (2024)
Abstract Obesity exacerbates tissue degeneration and compromises the integrity and reparative potential of mesenchymal stem/stromal cells (MSCs), but the underlying mechanisms have not been sufficiently elucidated. Mitochondria modulate the viability
Externí odkaz:
https://doaj.org/article/a7d07d1e8bb9470c95304e7432d4121a
Autor:
Jonathan A. R. Gordon, Coralee E. Tye, Bodhisattwa Banerjee, Prachi N. Ghule, Andre J. van Wijnen, Fleur S. Kabala, Natalie A. Page, Michelle M. Falcone, Janet L. Stein, Gary S. Stein, Jane B. Lian
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The skeleton forms from multipotent human mesenchymal stem cells (hMSCs) competent to commit to specific lineages. Long noncoding RNAs (lncRNAs) have been identified as key epigenetic regulators of tissue development. However, regulation of
Externí odkaz:
https://doaj.org/article/22d7cc53663c45a996950aef704e675e
Autor:
Dongyao Yan, Di Chen, Simon M Cool, Andre J van Wijnen, Katalin Mikecz, Gillian Murphy, Hee-Jeong Im
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/174408689eff4e6e9ca900272ba6e6a0
Autor:
Logan M. Glasstetter, Tomiwa S. Oderinde, Mohit Mirchandani, Kamalnath Sankaran Rajagopalan, Samer H. Barsom, Roman Thaler, Sarosh Siddiqi, Xiang-Yang Zhu, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Andre J. van Wijnen, Alfonso Eirin, Lilach O. Lerman
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Background Obesity dysregulates key biological processes underlying the functional homeostasis, fate decisions, and reparative potential of mesenchymal stem/stromal cells (MSCs). Mechanisms directing obesity-induced phenotypic alterations in
Externí odkaz:
https://doaj.org/article/6f680ad866984208b9f1e36b86773c4d
Autor:
Parisa Dashti, Eric A. Lewallen, Jonathan A.R. Gordon, Martin A. Montecino, Johannes P.T.M. van Leeuwen, Gary S. Stein, Bram C.J. van der Eerden, James R. Davie, Andre J. van Wijnen
Publikováno v:
Bone Reports, Vol 19, Iss , Pp 101704- (2023)
Osteogenic differentiation of mesenchymal cells is controlled by epigenetic enzymes that regulate post-translational modifications of histones. Compared to acetyl or methyltransferases, the physiological functions of protein arginine methyltransferas
Externí odkaz:
https://doaj.org/article/782923f9b7f54150befe4cda6e4e94a7
Autor:
Afton K. Limberg, Christopher G. Salib, Meagan E. Tibbo, Juan S. Vargas-Hernandez, Jacob W. Bettencourt, Banu Bayram, Charlotte E. Berry, Amel Dudakovic, Brad Bolon, Andre J. van Wijnen, Mark E. Morrey, Joaquin Sanchez-Sotelo, Daniel J. Berry, Jodi M. Carter, Matthew P. Abdel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Arthrofibrosis following total knee arthroplasty (TKA) is a debilitating condition typically diagnosed based on clinical findings. To gain insight into the histopathologic immune cell microenvironment of arthrofibrosis, we assessed the exten
Externí odkaz:
https://doaj.org/article/1c40645896924d1bb2bff3c1f5b012f5
Publikováno v:
Nucleus, Vol 13, Iss 1, Pp 35-48 (2022)
There is growing appreciation that architectural components of the nucleus regulate gene accessibility by altering chromatin organization. While nuclear membrane connector proteins link the mechanosensitive actin cytoskeleton to the nucleoskeleton, a
Externí odkaz:
https://doaj.org/article/90c25eff0d8a4ad19afa374dfd47e733
Autor:
Roman Thaler, Farzaneh Khani, Ines Sturmlechner, Sharareh S. Dehghani, Janet M. Denbeigh, Xianhu Zhou, Oksana Pichurin, Amel Dudakovic, Sofia S. Jerez, Jian Zhong, Jeong-Heon Lee, Ramesh Natarajan, Ivo Kalajzic, Yong-hui Jiang, David R. Deyle, Eleftherios P. Paschalis, Barbara M. Misof, Tamas Ordog, Andre J. van Wijnen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
For decades vitamin C’s primary function in bone has been attributed to its involvement in collagen synthesis. Here, the authors uncover that vitamin C’s central role in bone is to globally orchestrate osteogenesis via epigenetic mechanisms.
Externí odkaz:
https://doaj.org/article/03ddd7fcf25c4309b04599c7af2fbd14
Autor:
Amel Dudakovic, Sofia Jerez, Padmini J. Deosthale, Janet M. Denbeigh, Christopher R. Paradise, Martina Gluscevic, Pengfei Zan, Dana L. Begun, Emily T. Camilleri, Oksana Pichurin, Farzaneh Khani, Roman Thaler, Jane B. Lian, Gary S. Stein, Jennifer J. Westendorf, Lilian I. Plotkin, Andre J. van Wijnen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract High-throughput microRNA sequencing was performed during differentiation of MC3T3-E1 osteoblasts to develop working hypotheses for specific microRNAs that control osteogenesis. The expression data show that miR-101a, which targets the mRNAs
Externí odkaz:
https://doaj.org/article/f5c778c9a9e84a5d9acbf3c478897543