Zobrazeno 1 - 10 of 167 pro vyhledávání: '"A J, Vestal"'
1
Unraveling the Role of Guanylate-Binding Proteins (GBPs) in Breast Cancer: A Comprehensive Literature Review and New Data on Prognosis in Breast Cancer Subtypes
Autor: Erin N. Hunt, Jonathan P. Kopacz, Deborah J. Vestal
Publikováno v: Cancers; Volume 14; Issue 11; Pages: 2794
At least one member of the Guanylate-Binding Protein (GBP) family of large interferon-induced GTPases has been classified as both a marker of good prognosis and as a potential drug target to treat breast cancers. However, the activity of individual G
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1febd26439f077088327b4d2b9d79b2a
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2
The Large GTPase, GBP-2, Regulates Rho Family GTPases to Inhibit Migration and Invadosome Formation in Breast Cancer Cells
Autor: Ryan C. Kalb, Ankita V. Abnave, Jonathan P. Kopacz, Deborah J. Vestal, Samantha A. Heilman, Geoffrey O. Nyabuto, John P. Wilson
Publikováno v: Cancers, Vol 13, Iss 5632, p 5632 (2021)
Cancers
Volume 13
Issue 22
Simple Summary Too many women still die of breast cancer each year. Those breast cancers that kill are those with cells that have migrated away from the primary tumor in the breast and established new tumors at other sites in the body. These tumors a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e46565cf4e0fa54044ff57d76438749
https://doi.org/10.3390/cancers13225632
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3
The large GTPase, mGBP-2, regulates Rho family GTPases to inhibit migration and invadosome formation in Triple-Negative Breast Cancer cells
Autor: Geoffrey O. Nyabuto, Samantha A. Heilman, John P. Wilson, Deborah J. Vestal, Ankita V. Abnave, Ryan C. Kalb
Breast cancer is the most common cancer in women. Despite advances in early detection and treatment, it is predicted that over 40,000 women will die of breast cancer in 2019. This number of women is still too high. To lower this number, more informat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bcf132194cc7eb7f6d546ca15123808
https://doi.org/10.1101/679514
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6
hGBP-1 Expression Predicts Shorter Progression-Free Survival in Ovarian Cancers, While Contributing to Paclitaxel Resistance
Autor: Suzan Wadi, Deborah J. Vestal, Aaron R. Tipton, Jill A. Trendel, Sadik A. Khuder
Publikováno v: Journal of cancer therapy
Ovarian cancer is the gynecological cancer with the poorest prognosis. One significant reason is the development of resistance to the chemotherapeutic drugs used in its treatment. The large GTPase, hGBP-1, has been implicated in paclitaxel resistance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09923ef46a819478976f6a54a5cc1c74
https://pubmed.ncbi.nlm.nih.gov/28090373
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7
Guanylate-Binding Protein-1 protects ovarian cancer cell lines but not breast cancer cell lines from killing by paclitaxel
Autor: John P. Wilson, Geoffrey O. Nyabuto, Travis Mazur, Aaron R. Tipton, Jacob S. Justinger, Deborah J. Vestal, Jill A. Trendel, Peter T. Nguyen, Suzan Wadi, Garret L. Moore
Forced expression of the cytokine-induced large GTPase, human Guanylate-Binding Protein-1 (hGBP-1), in ovarian cancer cell lines increases resistance to paclitaxel. Elevated hGBP-1 RNA in ovarian tumors correlates with shorter recurrence-free surviva
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cfa0aaa6cee7b2e464c73e6c434a08b
https://europepmc.org/articles/PMC5030188/
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8
Role of GTP Binding, Isoprenylation, and the C-Terminal α-Helices in the Inhibition of Cell Spreading by the Interferon-Induced GTPase, Mouse Guanylate-Binding Protein-2
Autor: Sujata Balasubramanian, Angela F. Messmer-Blust, Deborah J. Vestal, Jonathan A. Jeyaratnam
Publikováno v: Journal of Interferon & Cytokine Research. 31:291-298
Interferon-γ pre-exposure inhibits Rac activation by either integrin engagement or platelet-derived growth factor treatment. Interferon-γ does this by inducing expression of the large guanosine triphosphatase (GTPase) mouse guanylate-binding protei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37139f90a23ff2bc505e1329f44fbba8
https://doi.org/10.1089/jir.2010.0056
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9
Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: differential requirement for wild-type GTP binding domain
Autor: V. Y. Gorbacheva, Deborah J. Vestal, C. C. Carter
Publikováno v: Archives of Virology. 150:1213-1220
Interferons (IFNs) exert their anti-viral activities through the induction of anti-viral proteins. One member of the guanylate binding protein (GBP) family of IFN-induced GTPases, hGBP-1, has previously been shown to contribute to the antiviral activ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0090baa0b8e19e7ed0062d7c1b046d
https://doi.org/10.1007/s00705-004-0489-2
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10
The Interferon (IFN)-induced GTPase, mGBP-2
Autor: Ganes C. Sen, Deborah J. Vestal, Daniel J. Lindner, Victoria Gorbacheva
Publikováno v: Journal of Biological Chemistry. 277:6080-6087
To investigate the function of mGBP-2, a member of the interferon (IFN)-induced guanylate-binding protein family of GTPases, NIH 3T3 fibroblasts were generated that constitutively expressed mGBP-2. mGBP-2 induced a faster growth rate, with the highes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbed42709ccc82934521f56d5a4e3459
https://doi.org/10.1074/jbc.m110542200
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