Zobrazeno 1 - 10
of 943
pro vyhledávání: '"A J, Sumner"'
Autor:
Stephen M. Brown, Aparna S. Ajjarapu, Divya Ramachandra, Laura Blasco‐Pérez, Mar Costa‐Roger, Eduardo F. Tizzano, Charlotte J. Sumner, Katherine D. Mathews
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 11, Pp 3042-3046 (2024)
Abstract Twin girls born at 30 weeks' gestation with spinal muscular atrophy (SMA) received onsasemnogene‐abeparvovec (OA) at 3.5 weeks of life. They had no treatment‐related adverse events, normal acquisition of motor milestones, and normal neur
Externí odkaz:
https://doaj.org/article/d5dc5d12e75c4010864e8957627976d6
Autor:
Wimal Pathmasiri, Blake R. Rushing, Susan McRitchie, Mansi Choudhari, Xiuxia Du, Alexsandr Smirnov, Matteo Pelleigrini, Michael J. Thompson, Camila A. Sakaguchi, David C. Nieman, Susan J. Sumner
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract This cross-sectional study investigated differences in the plasma metabolome in two groups of adults that were of similar age but varied markedly in body composition and dietary and physical activity patterns. Study participants included 52
Externí odkaz:
https://doaj.org/article/3b558d031c374c7c8e48ba554d5f0a1d
Publikováno v:
European Physical Journal C: Particles and Fields, Vol 84, Iss 5, Pp 1-16 (2024)
Abstract Muon-induced neutrons can lead to potentially irreducible backgrounds in rare event search experiments. We have investigated the implication of laboratory depth on the muon-induced background in a future dark matter experiment capable of rea
Externí odkaz:
https://doaj.org/article/afb3fd32b1ac4b119c2acf76631a8934
Autor:
Mark N. Wallace, Joel I. Berger, Adam Hockley, Christian J. Sumner, Michael A. Akeroyd, Alan R. Palmer, Peter A. McNaughton
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Rodent models of tinnitus are commonly used to study its mechanisms and potential treatments. Tinnitus can be identified by changes in the gap-induced prepulse inhibition of the acoustic startle (GPIAS), most commonly by using pressure detectors to m
Externí odkaz:
https://doaj.org/article/7bce62c9b78949f78828dff531e923c2
Autor:
M. Azpiroz‐Zabala, E. J. Sumner, M. J. B. Cartigny, J. Peakall, M. A. Clare, S. E. Darby, D. R. Parsons, R. M. Dorrell, E. Özsoy, D. Tezcan, R. B. Wynn, J. Johnson
Publikováno v:
The Depositional Record, Vol 10, Iss 1, Pp 159-175 (2024)
Abstract Submarine channels are key features for the transport of flow and nutrients into deep water. Previous studies of their morphology and channel evolution have treated these systems as abiotic, and therefore assume that physical processes are s
Externí odkaz:
https://doaj.org/article/a960bb9e198b4a10944ba8696b9fc649
Autor:
Beltran Borges, Antonia Varthaliti, Marisa Schwab, Maria T. Clarke, Christopher Pivetti, Nalin Gupta, Cathryn R. Cadwell, Ghiabe Guibinga, Shirley Phillips, Tony Del Rio, Fatih Ozsolak, Denise Imai-Leonard, Lingling Kong, Diana J. Laird, Akos Herzeg, Charlotte J. Sumner, Tippi C. MacKenzie
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101263- (2024)
Prenatal somatic cell gene therapy (PSCGT) could potentially treat severe, early-onset genetic disorders such as spinal muscular atrophy (SMA) or muscular dystrophy. Given the approval of adeno-associated virus serotype 9 (AAV9) vectors in infants wi
Externí odkaz:
https://doaj.org/article/d01f9d171e174897be32403a75098f3a
Autor:
Yuan-yuan Li, Supradeep S. Madduri, Erika T. Rezeli, Charlene Santos, Herman Freeman III, Jing Peng, Susan L. McRitchie, Wimal Pathmasiri, Stephen D. Hursting, Susan J. Sumner, Delisha A. Stewart
Publikováno v:
Frontiers in Nutrition, Vol 11 (2024)
IntroductionObesity is a multi-factorial disease frequently associated with poor nutritional habits and linked to many detrimental health outcomes. Individuals with obesity are more likely to have increased levels of persistent inflammatory and metab
Externí odkaz:
https://doaj.org/article/33951a7561284ad3a43b615ec536c51b
Autor:
Megan M. Knuth, Jing Xue, Marwa Elnagheeb, Raad Z. Gharaibeh, Sarah A. Schoenrock, Susan McRitchie, Cory Brouwer, Susan J. Sumner, Lisa Tarantino, William Valdar, R. Scott Rector, Jeremy M. Simon, Folami Ideraabdullah
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionEmerging data suggests liver disease may be initiated during development when there is high genome plasticity and the molecular pathways supporting liver function are being developed.MethodsHere, we leveraged our Collaborative Cross mouse
Externí odkaz:
https://doaj.org/article/8293d185b25b4bafb987226841c7403f
Autor:
Benedikt Goretzki, Christoph Wiedemann, Brett A. McCray, Stefan L. Schäfer, Jasmin Jansen, Frederike Tebbe, Sarah-Ana Mitrovic, Julia Nöth, Ainara Claveras Cabezudo, Jack K. Donohue, Cy M. Jeffries, Wieland Steinchen, Florian Stengel, Charlotte J. Sumner, Gerhard Hummer, Ute A. Hellmich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Intrinsically disordered regions (IDRs) are essential for membrane receptor regulation but often remain unresolved in structural studies. TRPV4, a member of the TRP vanilloid channel family involved in thermo- and osmosensation, has a large
Externí odkaz:
https://doaj.org/article/164d0c141a984b619e153ae313a859dd
Autor:
Do Hoon Kwon, Feng Zhang, Brett A. McCray, Shasha Feng, Meha Kumar, Jeremy M. Sullivan, Wonpil Im, Charlotte J. Sumner, Seok-Yong Lee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Crosstalk between ion channels and small GTPases is critical during homeostasis and disease, but little is known about the structural underpinnings of these interactions. TRPV4 is a polymodal, calcium-permeable cation channel that has emerge
Externí odkaz:
https://doaj.org/article/331aacbb49b14346b60ba84795aa8594