Zobrazeno 1 - 10
of 21
pro vyhledávání: '"A J, Schoonen"'
Autor:
Marie-José C van Lierop, Wynand Alkema, Anke J Laskewitz, Rein Dijkema, Hans M van der Maaden, Martin J Smit, Ralf Plate, Paolo G M Conti, Christan G J M Jans, C Marco Timmers, Constant A A van Boeckel, Scott J Lusher, Ross McGuire, Rene C van Schaik, Jacob de Vlieg, Ruben L Smeets, Claudia L Hofstra, Annemieke M H Boots, Marcel van Duin, Benno A Ingelse, Willem G E J Schoonen, Aldo Grefhorst, Theo H van Dijk, Folkert Kuipers, Wim H A Dokter
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48385 (2012)
Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGR
Externí odkaz:
https://doaj.org/article/6e9843e211b74a5b893e7e79339992e9
Autor:
Byeong-Ui Moon, Radoslaw Kwapiszewski, Klaas J. C. Wientjes, Sander Koster, Elisabeth Verpoorte, Ben H. C. Westerink, Adelbert J. Schoonen
Publikováno v:
Analytical Chemistry, 82(16), 6756-6763. AMER CHEMICAL SOC INC
The development of continuous glucose monitoring systems is a major trend in diabetes-related research. Small, easy-to-wear systems which are robust enough to function over many days without maintenance are the goal. We present a new sensing system f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed7bead9c938197a494c08c7cd9214f7
https://doi.org/10.1021/ac1000509
https://doi.org/10.1021/ac1000509
Autor:
Todd M. Martin, David M. DeMarini, Romualdo Benigni, D Kirkland, Paolo Mazzatorta, W G E J Schoonen, G Ouédraogo-Arras, Chihae Yang, R D Snyder, Ann M. Richard, Christoph Helma, Benoît Schilter, Emilio Benfenati
Publikováno v:
Journal of Environmental Science and Health, Part C. 27:57-90
Mutagenicity and carcinogenicity are endpoints of major environmental and regulatory concern. These endpoints are also important targets for development of alternative methods for screening and prediction due to the large number of chemicals of poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95178af0733fdb63b78e19513bd8db06
https://doi.org/10.1080/10590500902885593
https://doi.org/10.1080/10590500902885593
Publikováno v:
Toxicology in Vitro. 21:1592-1602
The HepG2 cell line is a valuable tool for screening for cytotoxicity in the early phase of pharmaceutical development. Some compounds which produce reactive and toxic metabolites, are classified as being toxic in HepG2 cells. In contrast, other comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb3dbe5991d9af098d2e4ba2ffb72e2
https://doi.org/10.1016/j.tiv.2007.06.017
https://doi.org/10.1016/j.tiv.2007.06.017
Publikováno v:
EXS. 99
The influence of combinatorial chemistry and high-throughput screening (HTS) technologies in the pharmaceutical industry during the last 10 years has been enormous. However, the attrition rate of drugs in the clinic due to toxicity during this period
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4381cad1d41c913d632d2d7cb83422da
https://pubmed.ncbi.nlm.nih.gov/19157069
https://pubmed.ncbi.nlm.nih.gov/19157069
Autor:
Hans Joenje, Cornelis Jakobs, Willem G. E. J. Schoonen, Joan M. Van der Klei-Van Moorsel, A. Handayani Wanamarta
Publikováno v:
Free Radical Biology and Medicine. 10:111-118
We have recently shown that exposure of Chinese hamster ovary (CHO) cells to a toxic dose of normobaric hyperoxia (98% O2 for 3 days) caused a disturbance of cellular energy metabolism, that is, respiratory failure followed by stimulation of glycolyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5346cbc254e9e9da2892f94dad216f
https://doi.org/10.1016/0891-5849(91)90004-m
https://doi.org/10.1016/0891-5849(91)90004-m
Autor:
J. M. van der Klei-van Moorsel, Willem G. E. J. Schoonen, Hans Joenje, A. H. Wanamarta, C. Jakobs
Publikováno v:
Scopus-Elsevier
Continuous exposure of Chinese hamster ovary (CHO) cells to an atmosphere of 98% O2, 2% CO2 (normobaric hyperoxia) leads within a period of several days to cytostasis and clonogenic cell death. Here we report respiratory failure as an important early
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33cb15195e95839191a5bf91ced50c3
https://doi.org/10.1016/s0021-9258(19)38565-5
https://doi.org/10.1016/s0021-9258(19)38565-5
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 19(4)
In this study the focus is on the comparison of fluorometric assays, using Alamar Blue (AB) and Hoechst 33342 coloration, and luminometric assays, using Cyto-Lite and ATP-Lite, for toxicity measurements. With AB, ATP-Lite and Cyto-Lite the energy sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::335f44f2a621abfd751ab2cce9aba98e
https://pubmed.ncbi.nlm.nih.gov/15826807
https://pubmed.ncbi.nlm.nih.gov/15826807
Autor:
K J, Wientjes, A J, Schoonen
Publikováno v:
The International journal of artificial organs. 24(12)
For the development and use of subcutaneous glucose sensors it is important to know the time lag between changes in blood glucose and subcutaneous interstitial glucose concentration. To determine the time lag we inserted a microdialysis probe into th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a149d3fe8273435610bf175597b70c38
https://pubmed.ncbi.nlm.nih.gov/11831594
https://pubmed.ncbi.nlm.nih.gov/11831594
Publikováno v:
Annals of the New York Academy of Sciences. 663:453-455
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f16f1577a86f5c5f219c10b952c5ff5
https://doi.org/10.1111/j.1749-6632.1992.tb38699.x
https://doi.org/10.1111/j.1749-6632.1992.tb38699.x