Zobrazeno 1 - 10
of 63
pro vyhledávání: '"A J, Roon"'
Autor:
Michael B. Robinson, James F. Koerner, Shankar Venkatraman, Rodney L. Johnson, Robert J. Roon, Christopher J. Tokar, Louis Littman
Publikováno v:
Journal of Medicinal Chemistry. 42:1639-1647
The conformationally constrained cyclobutane analogues of quisqualic acid (Z)- and (E)-1-amino-3-[2'-(3',5'-dioxo-1',2', 4'-oxadiazolidinyl)]cyclobutane-1-carboxylic acid, compounds 2 and 3, respectively, were synthesized. Both 2 and 3 stimulated pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a62090b5d5d69cb0c3c63b3cb517ec
https://doi.org/10.1021/jm9806897
https://doi.org/10.1021/jm9806897
Autor:
Robert J. Roon, James F. Koerner
Publikováno v:
Brain Research. 734:223-228
Exposure of slices of rat hippocampus to quisqualic acid produces an enhanced sensitivity of neurons to depolarization by other excitatory amino acid analogues, particularly amino acid phosphonates. The phosphonates may act at extracellular sites, si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b96e988cb6f8cda927bbaf8352545aa
https://doi.org/10.1016/0006-8993(96)00634-8
https://doi.org/10.1016/0006-8993(96)00634-8
Publikováno v:
Journal of Medicinal Chemistry. 37:3939-3946
The ability of quisqualic acid (1) to sensitize neurons to depolarization by omega-phosphono alpha-amino acid analogues of excitatory amino acids is a highly specific phenomenon and is termed the QUIS effect. In an attempt to elucidate the structure-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3697cccf67f5540da4160a6fab75a6
https://doi.org/10.1021/jm00049a013
https://doi.org/10.1021/jm00049a013
Publikováno v:
Brain Research. 649:203-207
Brief exposure of rat hippocampal slices to quisqualic acid (QUIS) sensitizes neurons to depolarization by the α-amino-ω-phosphonate excitatory amino acid (EAA) analogues AP4, AP5 and AP6. These phosphonates interact with a novel QUIS-sensitized si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3453f1e55031817086b955f95648299c
https://doi.org/10.1016/0006-8993(94)91065-0
https://doi.org/10.1016/0006-8993(94)91065-0
Publikováno v:
Brain Research. 605:85-92
Hippocampal CA1 pyramidal cell neurons are sensitized to depolarization by L-2-amino-4-phosphonobutanoic acid (L-AP4) following exposure to L-quisqualic acid (QUIS). It has been proposed that induction of this 'QUIS-effect' involves uptake of L-QUIS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2a7fa9fda12c7f5fea3336a7594625
https://doi.org/10.1016/0006-8993(93)91359-z
https://doi.org/10.1016/0006-8993(93)91359-z
Publikováno v:
Journal of Medicinal Chemistry. 35:4602-4607
Hippocampal CA1 pyramidal cell neurons are sensitized over 30-fold to depolarization by L-2-amino-4-phosphonobutanoic acid (L-AP4) following exposure to L-quisqualic acid. This phenomenon has been termed the QUIS effect. In the present study several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304dbe884dc0e9aa84849869a86fbc4f
https://doi.org/10.1021/jm00102a014
https://doi.org/10.1021/jm00102a014
Autor:
Anthony J. Roon, Deborah Hoogerwerf
Publikováno v:
Journal of Vascular Surgery. 16:239-243
To minimize morbidity in carotid surgery we have adopted the practice of routine operative arteriography. In our total experience of 692 carotid artery reconstructions done since 1979 no arteriography was used for the first 157 procedures. The combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d1f6a794f7ad3bead6a99ec7a5071da
https://doi.org/10.1016/0741-5214(92)90113-m
https://doi.org/10.1016/0741-5214(92)90113-m
Autor:
Nobuya W. Zempo, Anthony J. Roon
Publikováno v:
Journal of Vascular Surgery. 16:0239-0243
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5562dd3d9cda77877b3867f1d56c8524
https://doi.org/10.1067/mva.1992.36909
https://doi.org/10.1067/mva.1992.36909
Autor:
R J, Roon, J F, Koerner
Publikováno v:
Brain research. 734(1-2)
Exposure of slices of rat hippocampus to quisqualic acid produces an enhanced sensitivity of neurons to depolarization by other excitatory amino acid analogues, particularly amino acid phosphonates. The phosphonates may act at extracellular sites, si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1802be7aa21353bd7d7df330b9ce90e6
https://pubmed.ncbi.nlm.nih.gov/8896828
https://pubmed.ncbi.nlm.nih.gov/8896828
Publikováno v:
Journal of medicinal chemistry. 38(22)
The syntheses of several novel N-(hydroxydioxocyclobutenyl)-containing analogues of gamma-amino-butyric acid and L-glutamate were undertaken to test the hypothesis that derivatives of 3,4-dihydroxy-3-cyclobutene-1,2-dione (squaric acid), such as 3-am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491a38be0439239e5f308a0ba38c07ea
https://pubmed.ncbi.nlm.nih.gov/7473569
https://pubmed.ncbi.nlm.nih.gov/7473569