Zobrazeno 1 - 10
of 1 002
pro vyhledávání: '"A J, Lusis"'
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 10, Pp 100619- (2024)
Externí odkaz:
https://doaj.org/article/cc9f26efcdeb40d996538b3da9d30a01
Autor:
Sindre Lee-Ødegård, Marit Hjorth, Thomas Olsen, Gunn-Helen Moen, Emily Daubney, David M Evans, Andrea L Hevener, Aldons J Lusis, Mingqi Zhou, Marcus M Seldin, Hooman Allayee, James Hilser, Jonas Krag Viken, Hanne Gulseth, Frode Norheim, Christian A Drevon, Kåre Inge Birkeland
Publikováno v:
eLife, Vol 13 (2024)
Background: Physical activity has been associated with preventing the development of type 2 diabetes and atherosclerotic cardiovascular disease. However, our understanding of the precise molecular mechanisms underlying these effects remains incomplet
Externí odkaz:
https://doaj.org/article/d8371b2a65a34ab0b877c43460d1a3c0
Autor:
Sahereh Mirzaei, Holli A. DeVon, Rita M. Cantor, Arjen Cupido, Lilian Fernandes Silva, Markku Laakso, Aldons J. Lusis
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
BackgroundAn association between gut microbes and cardiovascular disease (CVD) has been established, but the underlying mechanisms remain largely unknown.MethodsWe conducted a secondary analysis of the cross-sectional data obtained from the Metabolic
Externí odkaz:
https://doaj.org/article/c6c6fd52b19148cb9bb877267853c124
Autor:
Frank Stappenbeck, Feng Wang, Satyesh K. Sinha, Simon T. Hui, Lia Farahi, Nigora Mukhamedova, Andrew Fleetwood, Andrew J. Murphy, Dmitri Sviridov, Aldons J. Lusis, Farhad Parhami
Publikováno v:
Cells, Vol 13, Iss 19, p 1632 (2024)
Background and aims: We previously reported that Oxy210, an oxysterol-based drug candidate, exhibits antifibrotic and anti-inflammatory properties. We also showed that, in mice, it ameliorates hepatic hallmarks of non-alcoholic steatohepatitis (NASH)
Externí odkaz:
https://doaj.org/article/650e6a06b1ad4cdc92e89f9bd3345b48
Autor:
Zeyneb Kurt, Jenny Cheng, Rio Barrere-Cain, Caden N McQuillen, Zara Saleem, Neil Hsu, Nuoya Jiang, Calvin Pan, Oscar Franzén, Simon Koplev, Susanna Wang, Johan Björkegren, Aldons J Lusis, Montgomery Blencowe, Xia Yang
Publikováno v:
eLife, Vol 12 (2023)
Mouse models have been used extensively to study human coronary artery disease (CAD) or atherosclerosis and to test therapeutic targets. However, whether mouse and human share similar genetic factors and pathogenic mechanisms of atherosclerosis has n
Externí odkaz:
https://doaj.org/article/e87fc1a00ff440dc9b28b69b90ccd82d
Autor:
Sahereh Mirzaei, Holli A. DeVon, Rita M. Cantor, Arjen J. Cupido, Calvin Pan, Sung Min Ha, Lilian Fernandes Silva, James R. Hilser, Jaana Hartiala, Hooman Allayee, Federico E. Rey, Markku Laakso, Aldons J. Lusis
Publikováno v:
Metabolites, Vol 14, Iss 3, p 174 (2024)
The role of gut microbe-derived metabolites in the development of metabolic syndrome (MetS) remains unclear. This study aimed to evaluate the associations of gut microbe-derived metabolites and MetS traits in the cross-sectional Metabolic Syndrome In
Externí odkaz:
https://doaj.org/article/1237cc0e945a40e497d0690efed8b753
Autor:
Hooman Allayee, Charles R Farber, Marcus M Seldin, Evan Graehl Williams, David E James, Aldons J Lusis
Publikováno v:
eLife, Vol 12 (2023)
Quantitative traits are often complex because of the contribution of many loci, with further complexity added by environmental factors. In medical research, systems genetics is a powerful approach for the study of complex traits, as it integrates int
Externí odkaz:
https://doaj.org/article/02a567f1967b4dd08c0627ee97eba3b3
Autor:
Simon T. Hui, Lili Gong, Chantle Swichkow, Montgomery Blencowe, Dorota Kaminska, Graciel Diamante, Calvin Pan, Meet Dalsania, Samuel W. French, Clara E. Magyar, Päivi Pajukanta, Jussi Pihlajamäki, Kristina I. Boström, Xia Yang, Aldons J. Lusis
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 6, Pp 943-960 (2023)
Background & Aims: Nonalcoholic steatohepatitis (NASH) is a complex disease involving both genetic and environmental factors in its onset and progression. We analyzed NASH phenotypes in a genetically diverse cohort of mice, the Hybrid Mouse Diversity
Externí odkaz:
https://doaj.org/article/17f948e14a694036a2a9724de594eb98
Autor:
Timothy M. Moore, Lijing Cheng, Dane M. Wolf, Jennifer Ngo, Mayuko Segawa, Xiaopeng Zhu, Alexander R. Strumwasser, Yang Cao, Bethan L. Clifford, Alice Ma, Philip Scumpia, Orian S. Shirihai, Thomas Q. de Aguiar Vallim, Markku Laakso, Aldons J. Lusis, Andrea L. Hevener, Zhenqi Zhou
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Parkin plays a role in mitophagy and has been shown to control adipose tissue browning and thermogenesis. Here the authors report that Parkin coordinates mitophagy with Pgc1α-mediated mitochondrial biogenesis in white adipocytes to regulate adiposit
Externí odkaz:
https://doaj.org/article/9e68195a11cc43e7b96aa4f54f9e6c1a
Autor:
Karthickeyan Chella Krishnan, Elie-Julien El Hachem, Mark P Keller, Sanjeet G Patel, Luke Carroll, Alexis Diaz Vegas, Isabela Gerdes Gyuricza, Christine Light, Yang Cao, Calvin Pan, Karolina Elżbieta Kaczor-Urbanowicz, Varun Shravah, Diana Anum, Matteo Pellegrini, Chi Fung Lee, Marcus M Seldin, Nadia A Rosenthal, Gary A Churchill, Alan D Attie, Benjamin Parker, David E James, Aldons J Lusis
Publikováno v:
eLife, Vol 12 (2023)
Mitochondria play an important role in both normal heart function and disease etiology. We report analysis of common genetic variations contributing to mitochondrial and heart functions using an integrative proteomics approach in a panel of inbred mo
Externí odkaz:
https://doaj.org/article/2a1b6fe7048b41d5bd20badbfb9d149f