Zobrazeno 1 - 10
of 856
pro vyhledávání: '"A J, Lerner"'
Autor:
Eric J. Lerner, Syed M. Hassan
Publikováno v:
Frontiers in Physics, Vol 12 (2024)
The dense plasma focus (DPF) device has great potential as a fusion energy generator using hydrogen-boron (pB11) fuel1. Experiments using deuterium have already demonstrated mean ion energies >200 keV, in the range needed for burning pB112. To test t
Externí odkaz:
https://doaj.org/article/c2b371de69b541dba8ca2c9d09621fbd
Autor:
Kathryn Martinez, ALAN J LERNER, Paul J Ford, Lauren R Sankary, Valerie Rico, Megan Zelinsky, Helen S Webster, Babak Tousi, James Leverenz
Publikováno v:
BMJ Open, Vol 14, Iss 8 (2024)
Introduction Informed decisions to enrol in the clinical investigations of Alzheimer’s disease and related dementias (ADRD) require careful consideration of complex risks and uncertain benefits. Decisions regarding whether to receive information ab
Externí odkaz:
https://doaj.org/article/4391d4a0c0f14482970f1fe636649a21
Autor:
S Yoo, E Garg, LT Elliott, RJ Hung, AR Halevy, JD Brooks, SB Bull, F Gagnon, CMT Greenwood, JF Lawless, AD Paterson, L Sun, MH Zawati, J Lerner-Ellis, RJS Abraham, I Birol, G Bourque, J-M Garant, C Gosselin, J Li, J Whitney, B Thiruvahindrapuram, J-A Herbrick, M Lorenti, MS Reuter, OO Adeoye, S Liu, U Allen, FP Bernier, CM Biggs, AM Cheung, J Cowan, M Herridge, DM Maslove, BP Modi, V Mooser, SK Morris, M Ostrowski, RS Parekh, G Pfeffer, O Suchowersky, J Taher, J Upton, RL Warren, RSM Yeung, N Aziz, SE Turvey, BM Knoppers, M Lathrop, SJM Jones, SW Scherer, LJ Strug
Publikováno v:
BMC Genomic Data, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract HostSeq was launched in April 2020 as a national initiative to integrate whole genome sequencing data from 10,000 Canadians infected with SARS-CoV-2 with clinical information related to their disease experience. The mandate of HostSeq is to
Externí odkaz:
https://doaj.org/article/8dd9330e73634673be15f3808eeffdfb
Autor:
Alan J. Lerner, Steven E. Arnold, Erin Maxfield, Aaron Koenig, Maria E. Toth, Brooke Fortin, Natalia Mast, Bianca A. Trombetta, John Denker, Andrew A. Pieper, Curtis Tatsuoka, Sangeetha Raghupathy, Irina A. Pikuleva
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-10 (2022)
Abstract Background Efavirenz is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is a CNS-specific enzyme that metabolizes cholesterol to 24-hydroxycholesterol (24HC). We have previously shown that allosteric CYP46A1 activation by low-dose efavi
Externí odkaz:
https://doaj.org/article/be51f0c921904c6eb9b8ba7aa6a50ed7
Autor:
Emily D. Clark, Jamie Perin, Nathan Herrmann, Olga Brawman‐Mintzer, Krista L. Lanctôt, Alan J. Lerner, Jacobo Mintzer, Prasad R. Padala, Paul B. Rosenberg, Susie Sami, David M. Shade, Christopher H. vanDyck, Anton P. Porsteinsson, for the ADMET‐2 Study Group
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 3, Pp n/a-n/a (2023)
Abstract INTRODUCTION Methylphenidate has been shown to improve apathy in patients with Alzheimer's disease (AD). The authors evaluated the impact of methylphenidate on neuropsychiatric symptoms (NPS) of AD, excluding apathy, using data from the Apat
Externí odkaz:
https://doaj.org/article/210c2f57d74546589949dbe33b0bd416
Publikováno v:
JMIR Serious Games, Vol 11, p e40931 (2023)
BackgroundCognitive assessment using tangible objects can measure fine motor and hand-eye coordination skills along with other cognitive domains. Administering such tests is often expensive, labor-intensive, and error prone owing to manual recording
Externí odkaz:
https://doaj.org/article/3f7ceb5f3c49402fa15f5b73121bac8b
Autor:
Susheel K. Gunasekar, Litao Xie, Ashutosh Kumar, Juan Hong, Pratik R. Chheda, Chen Kang, David M. Kern, Chau My-Ta, Joshua Maurer, John Heebink, Eva E. Gerber, Wojciech J. Grzesik, Macaulay Elliot-Hudson, Yanhui Zhang, Phillip Key, Chaitanya A. Kulkarni, Joseph W. Beals, Gordon I. Smith, Isaac Samuel, Jessica K. Smith, Peter Nau, Yumi Imai, Ryan D. Sheldon, Eric B. Taylor, Daniel J. Lerner, Andrew W. Norris, Samuel Klein, Stephen G. Brohawn, Robert Kerns, Rajan Sah
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-25 (2022)
Type 2 diabetes is associated with insulin resistance, impaired insulin secretion and liver steatosis. Here the authors report a proof-of-concept study for small molecule SWELL1 modulators as a therapeutic approach to treat diabetes and associated li
Externí odkaz:
https://doaj.org/article/f4d1fee19c624c0a9f1b40ef56f78e04
Autor:
Michael D. Osterman, Yeunjoo E. Song, Larry D. Adams, Renee A. Laux, Laura J. Caywood, Michael B. Prough, Jason E. Clouse, Sharlene D. Herington, Susan H. Slifer, Audrey Lynn, M. Denise Fuzzell, Sarada L. Fuzzell, Sherri D. Hochstetler, Kristy Miskimen, Leighanne R. Main, Daniel A. Dorfsman, Paula Ogrocki, Alan J. Lerner, Jairo Ramos, Jeffery M. Vance, Michael L. Cuccaro, William K. Scott, Margaret A. Pericak-Vance, Jonathan L. Haines
Publikováno v:
HGG Advances, Vol 3, Iss 3, Pp 100114- (2022)
Summary: Alzheimer disease (AD) is the most common type of dementia and is currently estimated to affect 6.2 million Americans. It ranks as the sixth leading cause of death in the United States, and the proportion of deaths due to AD has been increas
Externí odkaz:
https://doaj.org/article/b290236650874609abd0a2b092578853
Autor:
Connor Bargar, Wen Wang, Steven A. Gunzler, Alexandra LeFevre, Zerui Wang, Alan J. Lerner, Neena Singh, Curtis Tatsuoka, Brian Appleby, Xiongwei Zhu, Rong Xu, Vahram Haroutunian, Wen-Quan Zou, Jiyan Ma, Shu G. Chen
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-13 (2021)
Abstract Definitive diagnosis of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) relies on postmortem finding of disease-associated alpha-synuclein (αSynD) as misfolded protein aggregates in the central nervous system (CNS). The recen
Externí odkaz:
https://doaj.org/article/428f2d50f8b04b48843f8d5fdc2cbb25
Autor:
Krista L. Lanctôt, Clara Chen, Ethan Mah, Alex Kiss, Abby Li, Dave Shade, Roberta W. Scherer, Danielle Vieira, Hamadou Coulibaly, Paul B. Rosenberg, Alan J. Lerner, Prasad R. Padala, Olga Brawman-Mintzer, Christopher H. van Dyck, Anton P. Porsteinsson, Suzanne Craft, Allan Levey, William J. Burke, Jacobo Mintzer, Nathan Herrmann
Publikováno v:
International Psychogeriatrics. :1-9
Background: This paper used data from the Apathy in Dementia Methylphenidate Trial 2 (NCT02346201) to conduct a planned cost consequence analysis to investigate whether treatment of apathy with methylphenidate is economically attractive. Methods: A t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ffcbdcf06a86a605c613a294dd1c8d0
https://doi.org/10.1017/s1041610223000327
https://doi.org/10.1017/s1041610223000327