Zobrazeno 1 - 10
of 132
pro vyhledávání: '"A J, Highton"'
Autor:
Samuel E Norton, Tiffany Khong, Malarmathy Ramachandran, Andrew J Highton, Kirsten A Ward‐Hartstonge, Jake Shortt, Andrew Spencer, Roslyn A Kemp
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 12, Pp n/a-n/a (2023)
Abstract Objectives Lenalidomide (LEN) is used to treat multiple myeloma (MM) and shows in vitro synergy with KappaMab (KM), a chimeric antibody specific for Kappa Myeloma antigen, an antigen exclusively expressed on the surface of kappa‐restricted
Externí odkaz:
https://doaj.org/article/3c64e8fff2fb416e86b78486d31102b4
Autor:
Daniel S. March, Adam W. Hurt, Charlotte E. Grantham, Darren R. Churchward, Hannah M.L. Young, Patrick J. Highton, Maurice Dungey, Nicolette C. Bishop, Alice C. Smith, Matthew P.M. Graham-Brown, Nicola J. Cooper, James O. Burton
Publikováno v:
Kidney International Reports, Vol 6, Iss 6, Pp 1548-1557 (2021)
Introduction: No formal cost-effectiveness analysis has been performed for programs of cycling exercise during dialysis (intradialytic cycling [IDC]). The objective of this analysis is to determine the effect of a 6-month program of IDC on health car
Externí odkaz:
https://doaj.org/article/f3e364de9ecd43c4b204452e4119f73a
Autor:
Iain W. McNae, James Kinkead, Divya Malik, Li-Hsuan Yen, Martin K. Walker, Chris Swain, Scott P. Webster, Nick Gray, Peter M. Fernandes, Elmarie Myburgh, Elizabeth A. Blackburn, Ryan Ritchie, Carol Austin, Martin A. Wear, Adrian J. Highton, Andrew J. Keats, Antonio Vong, Jacqueline Dornan, Jeremy C. Mottram, Paul A. M. Michels, Simon Pettit, Malcolm D. Walkinshaw
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Glycolytic enzymes are challenging drug targets due to their highly conserved active sites and phosphorylated substrates. Here, the authors identify fast acting allosteric inhibitors of Trypanosoma brucei phosphofructokinase that block trypanosome gl
Externí odkaz:
https://doaj.org/article/4b5f2d939f554cc8b893fd1148232b4e
Autor:
Melanie J Davies, Thomas Yates, Sally J Singh, Joseph Henson, Harini Sathanapally, Ffion Curtis, Paddy C Dempsey, Hannah M L Young, Patrick J Highton, Louisa Y Herring, Jack Sargeant, Michelle Hadjiconstantinou, Rebecca Pritchard, Selina Lock
Publikováno v:
BMJ Open, Vol 12, Iss 5 (2022)
Introduction The number of people living with multiple long-term conditions (MLTCs) is predicted to rise. Within this population, those also living with frailty are particularly vulnerable to poor outcomes, including decreased function. Increased phy
Externí odkaz:
https://doaj.org/article/6085a79e6f3a421fbcbc0fb6ca3220dc
Autor:
Hamish CK Angus, Paulo CM Urbano, Gemma A Laws, Shijun Fan, Safina Gadeock, Michael Schultz, Grant Butt, Andrew J Highton, Roslyn A Kemp
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 8, Pp n/a-n/a (2022)
Abstract Objectives Crohn's disease (CD) initiation and pathogenesis are believed to involve an environmental trigger in a genetically susceptible person that results in an immune response against commensal gut bacteria, leading to a compromised inte
Externí odkaz:
https://doaj.org/article/50612b2adcad499cb4b121421df98e85
Autor:
Melanie J Davies, Kamlesh Khunti, Laura J Gray, Thomas Yates, Helen Dallosso, Samuel Seidu, Alex V Rowlands, Patrick J Highton, Louisa Y Herring, Sally Schreder, Emily J Smith, Ghazala Waheed, Ian Hudson
Publikováno v:
Open Heart, Vol 8, Iss 1 (2021)
Aim To assess the effectiveness of a low-cost pragmatic intervention (structured education and ongoing text message support) to increase daily physical activity in participants 12–48 months after a coronary heart disease cardiac event (myocardial i
Externí odkaz:
https://doaj.org/article/c2bae14ca5ee4fe3bfa5d0071b6e64a2
Autor:
Sally J Singh, Helen C Eborall, Simon Conroy, Alice C Smith, Hannah M L Young, Daniel S March, Patrick J Highton, Darren C Churchward, Charlotte Grantham, Samantha Goodliffe, William Jones, Mei-Mei Cheung, Sharlene A Greenwood, James O Burton
Publikováno v:
BMJ Open, Vol 10, Iss 11 (2020)
Objectives Frailty is highly prevalent in haemodialysis (HD) patients, leading to poor outcomes. This study aimed to determine whether a randomised controlled trial (RCT) of intradialytic exercise is feasible for frail HD patients, and explore how th
Externí odkaz:
https://doaj.org/article/cfe160de4f014cb18a5fec97599b7547
Autor:
Andrew J. Highton, Björn-Philipp Diercks, Franziska Möckl, Gloria Martrus, Jürgen Sauter, Alexander H. Schmidt, Madeleine J. Bunders, Christian Körner, Andreas H. Guse, Marcus Altfeld
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Natural killer (NK) cells are an important component of the innate immune system for the control of intracellular pathogens and cancer cells. NK cells demonstrate heterogeneous expression of inhibitory surface receptors. Signaling through these vario
Externí odkaz:
https://doaj.org/article/097851678ac4475a90956c3cbdae10aa
Autor:
Lauren L. O'Mahoney, Patrick J. Highton, Laura Kudlek, Jessica Morgan, Rosie Lynch, Ella Schofield, Nayanika Sreejith, Ajay Kapur, Afolarin Otunla, Sven Kerneis, Olivia James, Karen Rees, Ffion Curtis, Kamlesh Khunti, Jamie Hartmann‐Boyce
Publikováno v:
Diabetes, Obesity and Metabolism. 24:1850-1860
Covid-19 pandemic and lock down (LD) has affected diabetes care. We aimed to identify, appraise and synthesise available evidence on the impact of the pandemic on glycaemic control in people with diabetes. Materials and Methods We searched multiple d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480c3b814b7b5cb936c4fde561839114
https://doi.org/10.1111/dom.14771
https://doi.org/10.1111/dom.14771
Autor:
Andrew J. Highton, Madeleine E. Zinser, Lian Ni Lee, Claire L. Hutchings, Catherine De Lara, Chansavath Phetsouphanh, Chris B. Willberg, Claire L. Gordon, Paul Klenerman, Emanuele Marchi
Publikováno v:
Wellcome Open Research, Vol 4 (2019)
Background: Persistent viruses such as murine cytomegalovirus (MCMV) and adenovirus-based vaccines induce strong, sustained CD8+ T-cell responses, described as memory “inflation”. These retain functionality, home to peripheral organs and are asso
Externí odkaz:
https://doaj.org/article/bec4a62e35804da0864da57582d498ea