Zobrazeno 1 - 10
of 376
pro vyhledávání: '"A J, Grodzinsky"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Zhang et al. show that the Creb5 transcription factor regulates the formation of synovial joints, directs the genesis of articular cartilage, and regulates the shape of the ends of long bones by blocking Wnt5a expression in the perichondrium.
Externí odkaz:
https://doaj.org/article/64db8a61e2a24d0798d7ffa1343d46d7
Autor:
Garima Dwivedi, Lisa Flaman, Begum Alaybeyoglu, André Struglics, Eliot H. Frank, Susan Chubinskya, Stephen B. Trippel, Vicki Rosen, Murat Cirit, Alan J. Grodzinsky
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-18 (2022)
Abstract Background Traumatic knee injuries in humans trigger an immediate increase in synovial fluid levels of inflammatory cytokines that accompany impact damage to joint tissues. We developed a human in vitro cartilage-bone-synovium (CBS) cocultur
Externí odkaz:
https://doaj.org/article/522239d893064200834c5e4152161f6f
Autor:
Rebecca Mae Black, Lisa L. Flaman, Karin Lindblom, Susan Chubinskaya, Alan J. Grodzinsky, Patrik Önnerfjord
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-14 (2022)
Abstract Background Post-traumatic osteoarthritis (PTOA) does not currently have clinical prognostic biomarkers or disease-modifying drugs, though promising candidates such as dexamethasone (Dex) exist. Many challenges in studying and treating this d
Externí odkaz:
https://doaj.org/article/16b799ff818a47d8ad9dc4e456d61b02
Autor:
Joonas P Kosonen, Atte S A Eskelinen, Gustavo A Orozco, Petteri Nieminen, Donald D Anderson, Alan J Grodzinsky, Rami K Korhonen, Petri Tanska
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 1, p e1010337 (2023)
Osteoarthritis (OA) is a common musculoskeletal disease that leads to deterioration of articular cartilage, joint pain, and decreased quality of life. When OA develops after a joint injury, it is designated as post-traumatic OA (PTOA). The etiology o
Externí odkaz:
https://doaj.org/article/3a8c6b41b00c4d9f943981ac4df3f824
Autor:
Cheng-Hai Zhang, Yao Gao, Unmesh Jadhav, Han-Hwa Hung, Kristina M. Holton, Alan J. Grodzinsky, Ramesh A. Shivdasani, Andrew B. Lassar
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Zhang et al. identify Creb5 as a transcription factor that is required for induction of Prg4 expression by TGFβ and EGFR ligands. They show that Creb5 directly binds to two Prg4 promoter-proximal regulatory elements, working together with a more dis
Externí odkaz:
https://doaj.org/article/7960c992d8174a428cf9f533ac859690
Autor:
Rebecca Mae Black, Yang Wang, André Struglics, Pilar Lorenzo, Susan Chubinskaya, Alan J. Grodzinsky, Patrik Önnerfjord
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 3, Iss 4, Pp 100191- (2021)
Objectives: In this study, we apply a clustering method to proteomic data sets from bovine and human models of post-traumatic osteoarthritis (PTOA) to distinguish clusters of proteins based on their kinetics of release from cartilage and examined the
Externí odkaz:
https://doaj.org/article/093224d3d1db4fb5b53c424d4fb42dd0
Publikováno v:
Soft Matter. 19:3033-3046
An experimental technique to probe intramolecular interactions of PEG–PAMAM conjugates and surface charge presentation. Increasing PEG chain length increases non-covalent shielding, but increasing chain density decreases PEG surface association.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08d1e9b0d717e143afed517581434da5
https://doi.org/10.1039/d2sm01698b
https://doi.org/10.1039/d2sm01698b
Autor:
Rebecca Mae Black, Yang Wang, André Struglics, Pilar Lorenzo, Viveka Tillgren, Martin Rydén, Alan J. Grodzinsky, Patrik Önnerfjord
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 2, Iss 4, Pp 100099- (2020)
Summary: Objectives: In this exploratory study, we used discovery proteomics to follow the release of proteins from bovine knee articular cartilage in response to mechanical injury and cytokine treatment. We also studied the effect of the glucocortic
Externí odkaz:
https://doaj.org/article/15cb81ecb47d4e6cbfdb7673cf7b5853
Autor:
Atte S A Eskelinen, Petri Tanska, Cristina Florea, Gustavo A Orozco, Petro Julkunen, Alan J Grodzinsky, Rami K Korhonen
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 6, p e1007998 (2020)
Post-traumatic osteoarthritis (PTOA) is associated with cartilage degradation, ultimately leading to disability and decrease of quality of life. Two key mechanisms have been suggested to occur in PTOA: tissue inflammation and abnormal biomechanical l
Externí odkaz:
https://doaj.org/article/877f12712bd2418eabe7ae6dbf927cbe
Autor:
Chang-Wan Kim, Ali Hosseini, Lin Lin, Yang Wang, Martin Torriani, Thomas Gill, Alan J. Grodzinsky, Guoan Li
Publikováno v:
Journal of Orthopaedic Translation, Vol 12, Iss C, Pp 85-92 (2018)
Objective: To evaluate patient-specific patellofemoral joint (PFJ) cartilage 3 years postoperatively using T2 mapping magnetic resonance imaging and the uninjured contralateral side as control. Hypothesis: The cartilage of the PFJ in the anterior cru
Externí odkaz:
https://doaj.org/article/6b3b1b9c1dba4b3d8613f0d3665e26d3