Zobrazeno 1 - 10
of 75
pro vyhledávání: '"A J, Girgenti"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Various polygenic risk scores (PRS) methods have been proposed to combine the estimated effects of single nucleotide polymorphisms (SNPs) to predict genetic risks for common diseases, using data collected from genome-wide association studies
Externí odkaz:
https://doaj.org/article/adee2a3e380b452f8636b8418e56fd3b
Autor:
Gregory Rompala, Sheila T. Nagamatsu, José Jaime Martínez-Magaña, Diana L. Nuñez-Ríos, Jiawei Wang, Matthew J. Girgenti, John H. Krystal, Joel Gelernter, Traumatic Stress Brain Research Group, Yasmin L. Hurd, Janitza L. Montalvo-Ortiz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Opioid use disorder (OUD) is influenced by genetic and environmental factors. While recent research suggests epigenetic disturbances in OUD, this is mostly limited to DNA methylation (5mC). DNA hydroxymethylation (5hmC) has been widely under
Externí odkaz:
https://doaj.org/article/b44cff72bb7d48b28578738ba6c0cb13
Autor:
Emily M. Hicks, Carina Seah, Alanna Cote, Shelby Marchese, Kristen J. Brennand, Eric J. Nestler, Matthew J. Girgenti, Laura M. Huckins
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Major depressive disorder (MDD) is a complex and heterogeneous psychiatric syndrome with genetic and environmental influences. In addition to neuroanatomical and circuit-level disturbances, dysregulation of the brain transcriptome is a key p
Externí odkaz:
https://doaj.org/article/e730356031ed453faa6fc52a212004c7
Autor:
Ziheng Duan, Yi Dai, Ahyeon Hwang, Cheyu Lee, Kaichi Xie, Chutong Xiao, Min Xu, Matthew J Girgenti, Jing Zhang
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 9, p e1011444 (2023)
Different genes form complex networks within cells to carry out critical cellular functions, while network alterations in this process can potentially introduce downstream transcriptome perturbations and phenotypic variations. Therefore, developing e
Externí odkaz:
https://doaj.org/article/f1fa8a0a4700406b85f458ebfaff7341
Autor:
Janitza L. Montalvo-Ortiz, Joel Gelernter, Zhongshan Cheng, Matthew J. Girgenti, Ke Xu, Xinyu Zhang, Shyamalika Gopalan, Hang Zhou, Ronald S. Duman, Steven M. Southwick, John H. Krystal, Traumatic Stress Brain Research Study Group, Robert H. Pietrzak
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Posttraumatic stress disorder (PTSD) is a chronic and disabling psychiatric disorder prevalent in military veterans. Epigenetic mechanisms have been implicated in the etiology of PTSD, with DNA methylation being the most studied to identify
Externí odkaz:
https://doaj.org/article/9b03087f9a824d1cb85a96fc7bccecc2
Autor:
Sheila T. Nagamatsu, Gregory Rompala, Yasmin L. Hurd, Diana L. Núñez-Rios, Janitza L. Montalvo-Ortiz, Traumatic Stress Brain Research Group, Victor E. Alvarez, David Benedek, Alicia Che, Dianne A. Cruz, David A. Davis, Matthew J. Girgenti, Ellen Hoffman, Paul E. Holtzheimer, Bertrand R. Huber, Alfred Kaye, John H. Krystal, Adam T. Labadorf, Terence M. Keane, Mark W. Logue, Ann McKee, Brian Marx, Deborah Mash, Mark W. Miller, Crystal Noller, JM-O, William K. Scott, Paula Schnurr, Thor Stein, Robert Ursano, Douglas E. Williamson, Erika J. Wolf, Keith A. Young
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2023)
IntroductionDNA methylation (DNAm), an epigenetic mechanism, has been associated with opioid use disorder (OUD) in preclinical and human studies. However, most of the studies have focused on DNAm at CpG sites. DNAm at non-CpG sites (mCpHs, where H in
Externí odkaz:
https://doaj.org/article/8e534560e2b9492589d5919efc931441
Autor:
Che Yu Lee, Yuhang Chen, Ziheng Duan, Min Xu, Matthew J Girgenti, Ke Xu, Mark Gerstein, Jing Zhang
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010636 (2022)
Early and accurate detection of viruses in clinical and environmental samples is essential for effective public healthcare, treatment, and therapeutics. While PCR detects potential pathogens with high sensitivity, it is difficult to scale and require
Externí odkaz:
https://doaj.org/article/7bd62ffc0d0f47768fbe613db5244c5b
Autor:
Shivani Bhatt, Ansel T. Hillmer, Matthew J. Girgenti, Aleksandra Rusowicz, Michael Kapinos, Nabeel Nabulsi, Yiyun Huang, David Matuskey, Gustavo A. Angarita, Irina Esterlis, Margaret T. Davis, Steven M. Southwick, Matthew J. Friedman, Traumatic Stress Brain Study Group, Ronald S. Duman, Richard E. Carson, John H. Krystal, Robert H. Pietrzak, Kelly P. Cosgrove
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Neuroinflammation has been proposed to accompany the peripheral inflammation observed in PTSD. Here, authors find lower in vivo and postmortem levels of neuroimmune marker TSPO (translocator protein) in PTSD, in association with greater PTSD severity
Externí odkaz:
https://doaj.org/article/bb3f714c9295424b9a341b4b01971c9e
Autor:
Mark W. Logue, Zhenwei Zhou, Filomene G. Morrison, Erika J. Wolf, Nikolaos P. Daskalakis, Christos Chatzinakos, Foivos Georgiadis, Adam T. Labadorf, Matthew J. Girgenti, Keith A. Young, Douglas E. Williamson, Xiang Zhao, Jaclyn Garza Grenier, Bertrand Russell Huber, Mark W. Miller
Publikováno v:
Neurobiology of Stress, Vol 15, Iss , Pp 100398- (2021)
Studies evaluating neuroimaging, genetically predicted gene expression, and pre-clinical genetic models of PTSD, have identified PTSD-related abnormalities in the prefrontal cortex (PFC) of the brain, particularly in dorsolateral and ventromedial PFC
Externí odkaz:
https://doaj.org/article/9f856b09473743389bf2d11aa5c352d5
Publikováno v:
Neurobiology of Stress, Vol 15, Iss , Pp 100408- (2021)
Stress is the response of an organism to demands for change, yet excessive or chronic stress contributes to nearly all psychiatric disorders. The advent of high-throughput transcriptomic methods such as single cell RNA sequencing poses new opportunit
Externí odkaz:
https://doaj.org/article/6556e4491a7c4c639a5439e2ab28d3a9