Zobrazeno 1 - 10
of 611
pro vyhledávání: '"A J, Frew"'
Autor:
Philipp Seidel, Anne Rubarth, Kyra Zodel, Asin Peighambari, Felix Neumann, Yannick Federkiel, Hsin Huang, Rouven Hoefflin, Mojca Adlesic, Christian Witt, David J. Hoffmann, Patrick Metzger, Ralph K. Lindemann, Frank T. Zenke, Christoph Schell, Melanie Boerries, Dominik von Elverfeldt, Wilfried Reichardt, Marie Follo, Joachim Albers, Ian J. Frew
Publikováno v:
JCI Insight, Vol 7, Iss 24 (2022)
Metastatic clear cell renal cell carcinomas (ccRCCs) are resistant to DNA-damaging chemotherapies, limiting therapeutic options for patients whose tumors are resistant to tyrosine kinase inhibitors and/or immune checkpoint therapies. Here we show tha
Externí odkaz:
https://doaj.org/article/cf8515a3861b40da82fdcd8f12d444bb
Autor:
Marina Conde, Ian J. Frew
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 31, Iss , Pp 100814- (2022)
Bladder cancer (BC) develops from the tissues of the urinary bladder and is responsible for nearly 200,000 deaths annually. This review aims to integrate knowledge of recently discovered functions of the chromatin remodelling tumour suppressor protei
Externí odkaz:
https://doaj.org/article/4e8ca73c7b544e638e8a37d2f82a99ae
Autor:
Athina Ganner, Christina Gehrke, Marinella Klein, Lena Thegtmeier, Tanja Matulenski, Laura Wingendorf, Lu Wang, Felicitas Pilz, Lars Greidl, Lisa Meid, Fruzsina Kotsis, Gerd Walz, Ian J. Frew, Elke Neumann-Haefelin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Inactivation of the tumor suppressor von Hippel–Lindau (VHL) gene is a key event in hereditary and sporadic clear cell renal cell carcinomas (ccRCC). The mechanistic target of rapamycin (mTOR) signaling pathway is a fundamental regulator o
Externí odkaz:
https://doaj.org/article/241005f7df754cd8bd98e91ced3ed44d
Autor:
Daniel A. Mohl, Simon Lagies, Kyra Zodel, Matthias Zumkeller, Asin Peighambari, Athina Ganner, Dietmar A. Plattner, Elke Neumann-Haefelin, Mojca Adlesic, Ian J. Frew, Bernd Kammerer
Publikováno v:
Cells, Vol 12, Iss 8, p 1102 (2023)
Clear cell renal cell carcinoma (ccRCC) accounts for ~75% of kidney cancers. The biallelic inactivation of the von Hippel–Lindau tumor suppressor gene (VHL) is the truncal driver mutation of most cases of ccRCC. Cancer cells are metabolically repro
Externí odkaz:
https://doaj.org/article/c14feeae9dc44cb78d95daac398001d5
Autor:
Athina Ganner, Antonia Philipp, Simon Lagies, Laura Wingendorf, Lu Wang, Felicitas Pilz, Thomas Welte, Kelli Grand, Soeren S. Lienkamp, Marinella Klein, Bernd Kammerer, Ian J. Frew, Gerd Walz, Elke Neumann-Haefelin
Publikováno v:
Cells, Vol 12, Iss 6, p 835 (2023)
Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of renal cancer, and inactivation of the VHL tumor suppressor gene is found in almost all cases of hereditary and sporadic ccRCCs. CcRCC is associated with the reprogramm
Externí odkaz:
https://doaj.org/article/b0fde4aca05f4c8a94fede21fde25ff8
Autor:
Fiona J Gilbert, Scott Harris, Kenneth A Miles, Jonathan R Weir-McCall, Nagmi R Qureshi, Robert C Rintoul, Sabina Dizdarevic, Lucy Pike, Donald Sinclair, Andrew Shah, Rosemary Eaton, Andrew Clegg, Valerio Benedetto, James E Hill, Andrew Cook, Dimitrios Tzelis, Luke Vale, Lucy Brindle, Jackie Madden, Kelly Cozens, Louisa A Little, Kathrin Eichhorst, Patricia Moate, Chris McClement, Charles Peebles, Anindo Banerjee, Sai Han, Fat Wui Poon, Ashley M Groves, Lutfi Kurban, Anthony J Frew, Matthew E Callister, Philip Crosbie, Fergus V Gleeson, Kavitasagary Karunasaagarar, Osei Kankam, Steve George
Publikováno v:
Health Technology Assessment, Vol 26, Iss 17 (2022)
Background: Current pathways recommend positron emission tomography–computerised tomography for the characterisation of solitary pulmonary nodules. Dynamic contrast-enhanced computerised tomography may be a more cost-effective approach. Objectives:
Externí odkaz:
https://doaj.org/article/9f979849fb1a4980ad0e6621c366e572
Autor:
Rouven Hoefflin, Sabine Harlander, Silvia Schäfer, Patrick Metzger, Fengshen Kuo, Désirée Schönenberger, Mojca Adlesic, Asin Peighambari, Philipp Seidel, Chia-yi Chen, Miguel Consenza-Contreras, Andreas Jud, Bernd Lahrmann, Niels Grabe, Danijela Heide, Franziska M. Uhl, Timothy A. Chan, Justus Duyster, Robert Zeiser, Christoph Schell, Mathias Heikenwalder, Oliver Schilling, A. Ari Hakimi, Melanie Boerries, Ian J. Frew
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Genetic inactivation of VHL leads to stabilization of HIF-1α/HIF-2α and is associated with clear cell renal cell carcinoma (ccRCC) initiation and progression. Using an autochthonous mouse model of ccRCC with Vhl deletion, here the authors show that
Externí odkaz:
https://doaj.org/article/c9223cd55c18449db9d005eb65c4887e
Autor:
J.J. Wyatt, R.A. Pearson, J. Frew, C. Walker, N. Richmond, M. Wilkinson, K. Wilkes, S. Driver, S. West, P. Karen, R.L. Brooks-Pearson, D. Ainslie, E. Wilkins, H.M. McCallum
Publikováno v:
Radiography. 29:347-354
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4572c5a774d6daa80cd2dbc37b0a5040
https://doi.org/10.1016/j.radi.2023.01.015
https://doi.org/10.1016/j.radi.2023.01.015
Publikováno v:
Stem Cell Research, Vol 41, Iss , Pp - (2019)
Induced pluripotent stem cells (iPSCs) were generated from peripheral blood-derived erythroid progenitor cells obtained from a presymptomatic female carrying the heterozygous R418X progranulin (GRN) nonsense mutation, known to cause autosomal dominan
Externí odkaz:
https://doaj.org/article/b750638ae7834972a65d062463c1ff7f
Autor:
Ana Filipa Gonçalves, Mojca Adlesic, Simone Brandt, Tomas Hejhal, Sabine Harlander, Lukas Sommer, Olga Shakhova, Peter J. Wild, Ian J. Frew
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Renal angiomyolipomas (AML) contain a mix of clonal tumour cells. Here, through reverse tumour engineering experiments, mouse genetics and analyses of human AML tumours, the authors provide evidence that these mesenchymal tumours originate from renal
Externí odkaz:
https://doaj.org/article/7f63d8e6ed024233ba49cb91bfbd8004