Inflammation both increases and causes resistance to FGF23 in normal and uremic rats

Autor: Arnold J. Felsenfeld, María E. Rodríguez-Ortiz, Carmen Pineda, Mariano Rodriguez, Addy Montes de Oca, Juan M. Díaz-Tocados, Alberto Ortiz, Escolastico Aguilera-Tejero, Juan F. Alcala-Diaz, Yolanda Almaden, Julio M. Martinez-Moreno, Juan R. Muñoz-Castañeda, Rodrigo López-Baltanás, Carmen Herencia

Publikováno v: Clinical Science. 134:15-32

Fibroblast growth factor 23 (FGF23) increases phosphorus excretion and decreases calcitriol (1,25(OH)2D) levels. FGF23 increases from early stages of renal failure. We evaluated whether strict control of phosphorus intake in renal failure prevents th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733c06b392ce6c2e4f3317f3945b1241
https://doi.org/10.1042/cs20190779

Increased Phosphaturia Accelerates The Decline in Renal Function: A Search for Mechanisms

Autor: Erena Ruiz, Juan M. Díaz-Tocados, Rosa Ortega, Alejandro Martin-Malo, Arnold J. Felsenfeld, M. Victoria Pendón-Ruiz de Mier, Escolastico Aguilera-Tejero, Pedro Aljama, M. Dolores Salmerón-Rodríguez, Mariano Rodriguez, Rafael Santamaria, Noemi Vergara, Ana I. Raya, Ana Robles, Juan R. Muñoz-Castañeda

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports

In chronic kidney disease (CKD), high serum phosphate concentration is associated with cardiovascular disease and deterioration in renal function. In early CKD, the serum phosphate concentration is normal due to increased fractional excretion of phos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10ded190ce0797114cddfaef71460df
https://doaj.org/article/3a9044172f1e4892a96027f03d91d2fe

Differential regulation of renal Klotho and FGFR1 in normal and uremic rats

Autor: Maria Dolores Salmerón, Juan M. Díaz-Tocados, William G. Richards, María E. Rodríguez-Ortiz, Yolanda Almaden, Makoto Kuro-o, Carmen Herencia, Arnold J. Felsenfeld, Julio M. Martinez-Moreno, Juan R. Muñoz-Castañeda, Noemi Vergara, Maria Victoria Pendon-Ruiz de Mier, Mariano Rodriguez

Publikováno v: The FASEB Journal. 31:3858-3867

In renal failure, hyperphosphatemia occurs despite a marked elevation in serum fibroblast growth factor (FGF)-23. Abnormal regulation of the FGFR1-Klotho receptor complex may cause a resistance to the phosphaturic action of FGF23. The purpose of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1385fd7147df8c74af6f084dc39eb4c0
https://doi.org/10.1096/fj.201700006r

Phosphate control in reducing FGF23 levels in hemodialysis patients

Autor: Juan R. Muñoz-Castañeda, M. Antonia Alvarez-Lara, María E. Rodríguez-Ortiz, Alejandro Martin-Malo, M. Victoria Pendón-Ruiz de Mier, Pedro Aljama, M. Luisa Agüera, Mariano Rodriguez, Francisco Caravaca, Cristian Rodelo-Haad, Arnold J. Felsenfeld, Sagrario Soriano

Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
PLoS ONE
PLoS ONE, Vol 13, Iss 8, p e0201537 (2018)

BACKGROUND:In hemodialysis patients, high levels of Fibroblast Growth Factor 23 (FGF23) predict mortality. Our study was designed to test whether the control of serum phosphate is associated with a reduction in serum FGF23 levels. Additionally other

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a5fceca42eb202da2170bd6d4fd261
https://repositoriosaludmadrid.es/handle/20.500.12530/35924

Calcitonin, the forgotten hormone: does it deserve to be forgotten?

Autor: Barton S. Levine, Arnold J. Felsenfeld

Publikováno v: Clinical Kidney Journal

Calcitonin is a 32 amino acid hormone secreted by the C-cells of the thyroid gland. Calcitonin has been preserved during the transition from ocean-based life to land dwellers and is phylogenetically older than parathyroid hormone. Calcitonin secretio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eabc3d6f786d938ba46fcdf7b3230e1
http://europepmc.org/articles/PMC4370311