Výsledky vyhledávání - "A J, Eerenberg"

Interleukin 12 induces activation of fibrinolysis and coagulation in humans

Autor: J E, Portielje, W H, Kruit, A J, Eerenberg, M, Schuler, A, Sparreboom, C H, Lamers, R L, Bolhuis, G, Stoter, C, Huber, C, Hack

Publikováno v: British journal of haematology. 112(2)

Interleukin 12 (IL-12) has potential efficacy in malignant, infectious and allergic diseases. Its side-effects include activation of coagulation and fibrinolysis, as documented in chimpanzees. We assessed the coagulative and fibrinolytic response in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87f700b05800934a338a9684a29448ff
https://pubmed.ncbi.nlm.nih.gov/11167854

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Heparin-protamine complexes and C-reactive protein induce activation of the classical complement pathway: studies in patients undergoing cardiac surgery and in vitro

Autor: P, Bruins, H, te Velthuis, A J, Eerenberg-Belmer, A P, Yazdanbakhsh, E M, de Beaumont, L, Eijsman, A, Trouwborst, C E, Hack

Publikováno v: Thrombosis and haemostasis. 84(2)

The administration of protamine to patients undergoing cardiopulmonary bypass (CPB) to neutralize heparin and to reduce the risk of bleeding, induces activation of the classical complement pathway mainly by heparin-protamine complexes. We investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e66c9193973a0f75afb715cc243c488
https://pubmed.ncbi.nlm.nih.gov/10959695

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Inactivation of factor XIa in human plasma assessed by measuring factor XIa-protease inhibitor complexes: major role for C1-inhibitor

Autor: W A, Wuillemin, M, Minnema, J C, Meijers, D, Roem, A J, Eerenberg, J H, Nuijens, H, ten Cate, C E, Hack

Publikováno v: Blood. 85(6)

From experiments with purified proteins, it has been concluded that factor XIa (FXIa) is inhibited in plasma mainly by alpha 1-antitrypsin (a1AT), followed by antithrombin III (ATIII), C1-inhibitor (C1Inh), and alpha 2-antiplasmin (a2AP). However, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb7a6ce420c2051c9c756cea68d14c76
https://pubmed.ncbi.nlm.nih.gov/7534133

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Generation of plasmin during acute attacks of hereditary angioedema

Autor: M, Cugno, C E, Hack, J P, de Boer, A J, Eerenberg, A, Agostoni, M, Cicardi

Publikováno v: The Journal of laboratory and clinical medicine. 121(1)

Hereditary angioedema is caused by a genetic deficiency of C1-inhibitor, a serine protease inhibitor that regulates activation of complement, contact, and fibrinolytic systems. Symptoms (bouts of subcutaneous and mucous swelling) depend on the releas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::183ca722494d47b9d767374f3c7a7630
https://pubmed.ncbi.nlm.nih.gov/8426080

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Activation patterns of coagulation and fibrinolysis in baboons following infusion with lethal or sublethal dose of Escherichia coli

Autor: J P, de Boer, A A, Creasy, A, Chang, D, Roem, M C, Brouwer, A J, Eerenberg, C E, Hack, F B, Taylor

Publikováno v: Circulatory shock. 39(1)

Administration of low doses endotoxin or tumor necrosis factor (TNF) in human experimental models for sepsis results in transient activation of both coagulation and fibrinolysis and subsequent inhibition of the fibrinolytic system by plasminogen acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5849c14b9e751ed72b159b48d4890519
https://pubmed.ncbi.nlm.nih.gov/7683256

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Plasma elastase alpha 1-antitrypsin and lactoferrin in sepsis: evidence for neutrophils as mediators in fatal sepsis

Autor: J H, Nuijens, J J, Abbink, Y T, Wachtfogel, R W, Colman, A J, Eerenberg, D, Dors, A J, Kamp, R J, Strack van Schijndel, L G, Thijs, C E, Hack

Publikováno v: The Journal of laboratory and clinical medicine. 119(2)

Increased vasopermeability and vasodilation, presumably the result of endothelial perturbation, are considered among the basic pathogenetic mechanisms in septic shock. Neutrophils have been implicated as a source for mediators in endothelial injury.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::96618c086738a37d92b8dc4470f6771e
https://pubmed.ncbi.nlm.nih.gov/1740629

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Studies on the contact system of coagulation during therapy with high doses of recombinant IL-2: implications for septic shock

Autor: C E, Hack, J, Wagstaff, R J, Strack van Schijndel, A J, Eerenberg, H M, Pinedo, L G, Thijs, J H, Nuijens

Publikováno v: Thrombosis and haemostasis. 65(5)

Patients treated with high doses of interleukin-2 (IL-2) because of cancer, develop hemodynamic and vasopermeability changes, that resemble those observed in sepsis. These patients thus provide a unique opportunity to study the early events in the de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26d4d6518c5dff34ea6733055dbc28e8
https://pubmed.ncbi.nlm.nih.gov/1871710

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Quantification of functional and inactivated alpha 2-macroglobulin in sepsis

Autor: J J, Abbink, J H, Nuijens, A J, Eerenberg, C C, Huijbregts, R J, Strack van Schijndel, L G, Thijs, C E, Hack

Publikováno v: Thrombosis and haemostasis. 65(1)

Alpha 2-macroglobulin (alpha 2 M) in vitro inhibits numerous proteinases that are generated during inflammatory reactions and therefore, probably plays an important role in diseases such as sepsis. To monitor the state of alpha 2 M in sepsis, we deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5732cc00d5054dbf3337b706870874a1
https://pubmed.ncbi.nlm.nih.gov/1708920

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