Výsledky vyhledávání - "A J, Czernik"

Akademický článek

PPARG in osteocytes controls cell bioenergetics and systemic energy metabolism independently of sclerostin levels in circulation

Autor: Sudipta Baroi, Piotr J. Czernik, Mohd Parvez Khan, Joshua Letson, Emily Crowe, Amit Chougule, Patrick R. Griffin, Clifford J. Rosen, Beata Lecka-Czernik

Publikováno v: Molecular Metabolism, Vol 88, Iss , Pp 102000- (2024)

Objective: The skeleton is one of the largest organs in the body, wherein metabolism is integrated with systemic energy metabolism. However, the bioenergetic programming of osteocytes, the most abundant bone cells coordinating bone metabolism, is not

Externí odkaz: https://doaj.org/article/fd12f41dade74bab8b4e130e40b8ee7d

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Akademický článek

Osteocytes contribute via nuclear receptor PPAR-alpha to maintenance of bone and systemic energy metabolism

Autor: Amit Chougule, Sudipta Baroi, Piotr J. Czernik, Emily Crowe, Mi Ra Chang, Patrick R. Griffin, Beata Lecka-Czernik

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

IntroductionThe view that bone and energy metabolism are integrated by common regulatory mechanisms is broadly accepted and supported by multiple strands of evidence. This includes the well-characterized role of the PPARγ nuclear receptor, which is

Externí odkaz: https://doaj.org/article/1271eab095ab49fd80e70e0f7b44a2e0

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Akademický článek

Nonenzymatic and Trophic Activities of Carboxypeptidase E Regulate Bone Mass and Bioenergetics of Skeletal Stem Cells in Mice

Autor: Amit Chougule, Vipula Kolli, Sudipta Baroi, Nabil Ebraheim, Piotr J Czernik, Y Peng Loh, Beata Lecka‐Czernik

Publikováno v: JBMR Plus, Vol 4, Iss 9, Pp n/a-n/a (2020)

ABSTRACT Bone and energy metabolism are integrated by common regulatory mechanisms. Carboxypeptidase E (CPE), also known as obesity susceptibility protein or neurotrophic factor‐α1, is recognized for its function in processing prohormones, includi

Externí odkaz: https://doaj.org/article/a6d51828a21b4010acc55afefe998b2d

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Akademický článek

Marrow Adipose Tissue: Skeletal Location, Sexual Dimorphism, and Response to Sex Steroid Deficiency

Autor: Beata Lecka-Czernik, Lance A. Stechschulte, Piotr J. Czernik, Shermel B. Sherman, Shilong Huang, Amrei Krings

Publikováno v: Frontiers in Endocrinology, Vol 8 (2017)

Marrow adipose tissue (MAT) is unique with respect to origin, metabolism, and function. MAT is characterized with high heterogeneity which correlates with skeletal location and bone metabolism. This fat depot is also highly sensitive to various hormo

Externí odkaz: https://doaj.org/article/d81f0a3e699f4a93b99f4f1804477719

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Reconstitution of the host holobiont in germ-free born male rats acutely increases bone growth and affects marrow cellular content

Autor: Yuan Tian, Jiyoun Yeo, Sudipta Baroi, Xi Cheng, Beng San Yeoh, Andrew D. Patterson, Matam Vijay-Kumar, Beata Lecka-Czernik, Piu Saha, Bina Joe, Saroj Chakraborty, Rachel M. Golonka, Blair Mell, Piotr J. Czernik, Ahmed A. Abokor

Publikováno v: Physiol Genomics

Integration of microbiota in a host begins at birth and progresses during adolescence, forming a multidirectional system of physiological interactions. Here, we present an instantaneous effect of natural, bacterial gut colonization on the acceleratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575acd975302d391efbee28b4cf1f1ca
https://pubmed.ncbi.nlm.nih.gov/34714176

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14-3-3ζ: A suppressor of inflammatory arthritis

Autor: Joseph Holoshitz, Youjie Zhang, Joshua Kim, Ritu Chakravarti, Saurabh Chattopadhyay, Krista Chun, Blair Mell, Jenna McGowan, Bina Joe, Piotr J. Czernik

Publikováno v: Proc Natl Acad Sci U S A

Inflammatory arthritis (IA) is a common disease that affects millions of individuals worldwide. Proinflammatory events during IA pathogenesis are well studied; however, loss of protective immunity remains underexplored. Earlier, we reported that 14-3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d9b1b5c2c509fb281fdd836fc3d0c2
https://doi.org/10.1073/pnas.2025257118

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Akademický článek

Partial agonist, telmisartan, maintains PPARγ serine 112 phosphorylation, and does not affect osteoblast differentiation and bone mass.

Autor: Vipula Kolli, Lance A Stechschulte, Abigail R Dowling, Sima Rahman, Piotr J Czernik, Beata Lecka-Czernik

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e96323 (2014)

Peroxisome proliferator activated receptor gamma (PPARγ) controls both glucose metabolism and an allocation of marrow mesenchymal stem cells (MSCs) toward osteoblast and adipocyte lineages. Its activity is determined by interaction with a ligand whi

Externí odkaz: https://doaj.org/article/af179a5352ae4948a481dd6c3308e4fe

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