Zobrazeno 1 - 10
of 1 061
pro vyhledávání: '"A J, Cowley"'
Autor:
Jordan Staunton, Pamela Ajuyah, Angela Harris, Chelsea Mayoh, Marie Wong, Megan Rumford, Patricia J. Sullivan, Paul G. Ekert, Noemi Fuentes-Bolanos, Mark J. Cowley, Loretta M. S. Lau, David S. Ziegler, Paulette Barahona, Neevika Manoharan
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-7 (2024)
Abstract Noonan Syndrome (NS) is associated with an increased risk of low-grade central nervous system tumours in children but only very rarely associated with high-grade gliomas. Here we describe the first reported case of a spinal high-grade astroc
Externí odkaz:
https://doaj.org/article/f3ea3867fb7b4b96ba99217da50f78f6
Autor:
Kathleen I. Pishas, Karla J. Cowley, Marta Llaurado-Fernandez, Hannah Kim, Jennii Luu, Robert Vary, Nikola A. Bowden, Ian G. Campbell, Mark S. Carey, Kaylene J. Simpson, Dane Cheasley
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-15 (2024)
Abstract Low grade serous carcinoma (LGSOC) is a rare epithelial ovarian cancer with unique molecular characteristics compared to the more common tubo-ovarian high-grade serous ovarian carcinoma. Pivotal clinical trials guiding the management of epit
Externí odkaz:
https://doaj.org/article/1edb064d2b3943ada492808c792f4438
Autor:
Stephen J. Cowley
Publikováno v:
Languages, Vol 9, Iss 7, p 252 (2024)
Made in languaging aims to help ecolinguists with recrafting ideation and human practices. Inspired by Alexander and Stibbe, I turn to how ecolinguistic expertise can favour life-sustaining relations. In approaching normative goals, I start with how
Externí odkaz:
https://doaj.org/article/32bc9b4684014f1299797f38802fa721
Autor:
Yvonne Hort, Patricia Sullivan, Laura Wedd, Lindsay Fowles, Igor Stevanovski, Ira Deveson, Cas Simons, Andrew Mallett, Chirag Patel, Timothy Furlong, Mark J. Cowley, John Shine, Amali Mallawaarachchi
Publikováno v:
npj Genomic Medicine, Vol 8, Iss 1, Pp 1-9 (2023)
Abstract Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of kidney failure and is primarily associated with PKD1 or PKD2. Approximately 10% of patients remain undiagnosed after standard genetic testing. We aime
Externí odkaz:
https://doaj.org/article/b507e9f1aada4066a17ff8395cfbf357
Autor:
Patricia J. Sullivan, Velimir Gayevskiy, Ryan L. Davis, Marie Wong, Chelsea Mayoh, Amali Mallawaarachchi, Yvonne Hort, Mark J. McCabe, Sarah Beecroft, Matilda R. Jackson, Peer Arts, Andrew Dubowsky, Nigel Laing, Marcel E. Dinger, Hamish S. Scott, Emily Oates, Mark Pinese, Mark J. Cowley
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Predicting the impact of coding and noncoding variants on splicing is challenging, particularly in non-canonical splice sites, leading to missed diagnoses in patients. Existing splice prediction tools are complementary but knowing which to u
Externí odkaz:
https://doaj.org/article/a68b29b28f7044f1a5d703764aca0078
Autor:
Chelsea Mayoh, Andrew J. Gifford, Rachael Terry, Loretta M. S. Lau, Marie Wong, Padmashree Rao, Tyler Shai-Hee, Federica Saletta, Dong-Anh Khuong-Quang, Vicky Qin, Marion K. Mateos, Deborah Meyran, Katherine E. Miller, Aysen Yuksel, Emily V. A. Mould, Rachel Bowen-James, Dinisha Govender, Akanksha Senapati, Nataliya Zhukova, Natacha Omer, Hetal Dholaria, Frank Alvaro, Heather Tapp, Yonatan Diamond, Luciano Dalla Pozza, Andrew S. Moore, Wayne Nicholls, Nicholas G. Gottardo, Geoffrey McCowage, Jordan R. Hansford, Seong-Lin Khaw, Paul J. Wood, Daniel Catchpoole, Catherine E. Cottrell, Elaine R. Mardis, Glenn M. Marshall, Vanessa Tyrrell, Michelle Haber, David S. Ziegler, Orazio Vittorio, Joseph A. Trapani, Mark J. Cowley, Paul J. Neeson, Paul G. Ekert
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background Molecular profiling of the tumour immune microenvironment (TIME) has enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME of paediatric cancers is relatively unexplored. We speculated that a
Externí odkaz:
https://doaj.org/article/fbd7979e6f4b4aebb70a711623639d1f
Autor:
Pamela Ajuyah, Chelsea Mayoh, Loretta M. S. Lau, Paulette Barahona, Marie Wong, Hazel Chambers, Fatima Valdes-Mora, Akanksha Senapati, Andrew J. Gifford, Colleen D’Arcy, Jordan R. Hansford, Neevika Manoharan, Wayne Nicholls, Molly M. Williams, Paul J. Wood, Mark J. Cowley, Vanessa Tyrrell, Michelle Haber, Paul G. Ekert, David S. Ziegler, Dong-Anh Khuong-Quang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Diffuse midline gliomas (DMG) harbouring H3K27M mutation are paediatric tumours with a dismal outcome. Recently, a new subtype of midline gliomas has been described with similar features to DMG, including loss of H3K27 trimethylation, but la
Externí odkaz:
https://doaj.org/article/8e8fabf3268f4381b287194aa795890c
Autor:
Susanne Ramm, Robert Vary, Twishi Gulati, Jennii Luu, Karla J. Cowley, Michael S. Janes, Nicholas Radio, Kaylene J. Simpson
Publikováno v:
Organoids, Vol 2, Iss 1, Pp 1-19 (2022)
Technical advances in microscopy and automation have enabled image-based phenotypic screening of spheroids and organoids to become increasingly high throughput and high content at the same time. In particular, matrix-embedded 3D structures can recapi
Externí odkaz:
https://doaj.org/article/9872d9af8f674af8a0a211c1ce1aa687
Autor:
Vinochani Pillay, Lipi Shukla, Prad Herle, Simon Maciburko, Nadeeka Bandara, Isabella Reid, Steven Morgan, Yinan Yuan, Jennii Luu, Karla J. Cowley, Susanne Ramm, Kaylene J. Simpson, Marc G. Achen, Steven A. Stacker, Ramin Shayan, Tara Karnezis
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Surgery and radiotherapy are key cancer treatments and the leading causes of damage to the lymphatics, a vascular network critical to fluid homeostasis and immunity. The clinical manifestation of this damage constitutes a devastating si
Externí odkaz:
https://doaj.org/article/606001842ee84fea84121c90aaec3c6e
Autor:
Jacqueline P. Whitehouse, Hilary Hii, Chelsea Mayoh, Marie Wong, Pamela Ajuyah, Paulette Barahona, Louise Cui, Hetal Dholaria, Christine L. White, Molly K. Buntine, Jacob Byrne, Keteryne Rodrigues da Silva, Meegan Howlett, Emily J. Girard, Maria Tsoli, David S. Ziegler, Jason M. Dyke, Sharon Lee, Paul G. Ekert, Mark J. Cowley, Nicholas G. Gottardo, Raelene Endersby
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionEpendymomas (EPN) are the third most common malignant brain cancer in children. Treatment strategies for pediatric EPN have remained unchanged over recent decades, with 10-year survival rates stagnating at just 67% for children aged 0-14
Externí odkaz:
https://doaj.org/article/009c2573d20c46b8a58d763a746781a4