Výsledky vyhledávání

Regulation of skeletal muscle hexokinase II by insulin in nondiabetic and NIDDM subjects

Autor: Jerrold M. Olefsky, Mim I. Mulford, J Baloga, Joseph G. Yu, Yolanta T. Kruszynska

Publikováno v: Diabetes. 47:1107-1113

Impaired muscle glucose phosphorylation to glucose-6-phosphate by hexokinases (HKs)-I and -II may contribute to insulin resistance in NIDDM and obesity. HK-II expression is regulated by insulin. We tested the hypothesis that basal and insulin-stimula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df9883c0c27b57ec3423349adf30e9e4
https://doi.org/10.2337/diabetes.47.7.1107

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Evidence for decreased splanchnic glucose uptake after oral glucose administration in non-insulin-dependent diabetes mellitus

Autor: Bernhard Ludvik, J M Bell, J Baloga, John J. Nolan, M Joyce, A Roberts, Jerrold M. Olefsky

Publikováno v: Journal of Clinical Investigation. 100:2354-2361

The role of splanchnic glucose uptake (SGU) after oral glucose administration as a potential factor contributing to postprandial hyperglycemia in non-insulin-dependent diabetes mellitus (NIDDM) has not been established conclusively. Therefore, we inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1294bd1e63602f6a06c6fce2a1ec433d
https://doi.org/10.1172/jci119775

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Effect of obesity on insulin resistance in normal subjects and patients with NIDDM

Autor: J Baloga, David A. Sacks, Jerrold M. Olefsky, Bernhard Ludvik, John J. Nolan

Publikováno v: Diabetes. 44:1121-1125

Insulin resistance (IR) is a characteristic feature of non-insulin-dependent diabetes mellitus (NIDDM) as well as obesity, and a majority of NIDDM patients are obese. To assess the effect of obesity independent of NIDDM on IR, we studied the relation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13895588d72f0f91aac96eff733b5c09
https://doi.org/10.2337/diabetes.44.9.1121

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Mechanisms of the kinetic defect in insulin action in obesity and NIDDM

Autor: Bernhard Ludvik, John J. Nolan, Jerrold M. Olefsky, J Baloga, Donna Reichart

Publikováno v: Diabetes. 46(6)

To evaluate kinetic defects in insulin action, we performed time-course studies during hyperinsulinemic (120 mU x m(-2) x min(-1)) isoglycemic clamps in seven subjects with NIDDM (194 +/- 29 mg/dl) and in seven lean and seven obese nondiabetic subjec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c88a2a6bf8f193b3ba135619b3b2e4d
https://pubmed.ncbi.nlm.nih.gov/9166671

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A noninvasive method to measure splanchnic glucose uptake after oral glucose administration

Autor: M Joyce, A Roberts, John J. Nolan, Bernhard Ludvik, Jerrold M. Olefsky, J M Bell, J Baloga

Publikováno v: The Journal of clinical investigation. 95(5)

We have developed a noninvasive method to estimate splanchnic glucose uptake (SGU) in humans (oral glucose clamp technique [OG-CLAMP]), which combines a hyperinsulinemic clamp with an oral glucose load (oral glucose tolerance test). We validated this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384eaf8012ccc2c01357fe9e5e4a8563
https://pubmed.ncbi.nlm.nih.gov/7738188

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Detection of occult gallbladder disease by duodenal drainage collected endoscopically. A clinical and pathologic correlation

Autor: P W, Susann, F, Sheppard, A J, Baloga

Publikováno v: The American surgeon. 51(3)

The bile of 100 patients with abdominal pain (suspected of having gallbladder disease) was collected from the duodenum at the time of esophagogastroduodenoscopy and examined for cholesterol and calcium bilirubinate crystals. Sixty of these patients h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::53e1ba70bae324a40ca81d03e7ea3884
https://pubmed.ncbi.nlm.nih.gov/3883867

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