Zobrazeno 1 - 10
of 43
pro vyhledávání: '"A I de las Heras"'
Autor:
Rafal Czapiewski, Dzmitry G. Batrakou, Jose I. de las Heras, Roderick N. Carter, Aishwarya Sivakumar, Magdalena Sliwinska, Charles R. Dixon, Shaun Webb, Giovanna Lattanzi, Nicholas M. Morton, Eric C. Schirmer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Little is known how spatial genome organization is directed in fat; however, key proadipogenic genes reposition from the nuclear envelope (NE) to the interior during adipogenesis. Here the authors show that deletion of NE protein Tmem120a in adipocyt
Externí odkaz:
https://doaj.org/article/5efba97324ba4758897fa78e06687621
Autor:
Charles R. Dixon, Poonam Malik, Jose I. de las Heras, Natalia Saiz-Ros, Flavia de Lima Alves, Mark Tingey, Eleanor Gaunt, A. Christine Richardson, David A. Kelly, Martin W. Goldberg, Greg J. Towers, Weidong Yang, Juri Rappsilber, Paul Digard, Eric C. Schirmer
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103055- (2021)
Summary: STimulator of INterferon Genes (STING) is an adaptor for cytoplasmic DNA sensing by cGAMP/cGAS that helps trigger innate immune responses (IIRs). Although STING is mostly localized in the ER, we find a separate inner nuclear membrane pool of
Externí odkaz:
https://doaj.org/article/7c77bb3feb48478187feaae2f2cec97e
Autor:
Leonardo Gatticchi, Jose I. de las Heras, Aishwarya Sivakumar, Nikolaj Zuleger, Rita Roberti, Eric C. Schirmer
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Tissue-specific patterns of radial genome organization contribute to genome regulation and can be established by nuclear envelope proteins. Studies in this area often use cancer cell lines, and it is unclear how well such systems recapitulate genome
Externí odkaz:
https://doaj.org/article/6d453fadf9dc4d5a966ea2534975fcbc
Autor:
Peter Meinke, Alastair R.W. Kerr, Rafal Czapiewski, Jose I. de las Heras, Charles R. Dixon, Elizabeth Harris, Heike Kölbel, Francesco Muntoni, Ulrike Schara, Volker Straub, Benedikt Schoser, Manfred Wehnert, Eric C. Schirmer
Publikováno v:
EBioMedicine, Vol 51, Iss , Pp - (2020)
Background: As genome-wide approaches prove difficult with genetically heterogeneous orphan diseases, we developed a new approach to identify candidate genes. We applied this to Emery-Dreifuss muscular dystrophy (EDMD), characterised by early onset c
Externí odkaz:
https://doaj.org/article/e946bd122b21483d83d43af02176d4fb
Autor:
Inês J. de Castro, James Budzak, Maria L. Di Giacinto, Lorena Ligammari, Ezgi Gokhan, Christos Spanos, Daniela Moralli, Christine Richardson, Jose I. de las Heras, Silvia Salatino, Eric C. Schirmer, Katharine S. Ullman, Wendy A. Bickmore, Catherine Green, Juri Rappsilber, Sarah Lamble, Martin W. Goldberg, Veronica Vinciotti, Paola Vagnarelli
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Repo-Man is a chromosome-binding subunit of protein phosphatase 1 to regulate mitosis. Here, de Castro and colleagues show that Repo-Man also regulates heterochromatin during interphase, and regulates gene repression and chromatin organization.
Externí odkaz:
https://doaj.org/article/614dab2625cb407a8fec9084fc97d570
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Every living organism, from bacteria to humans, contains DNA encoding anything from a few hundred genes in intracellular parasites such as Mycoplasma, up to several tens of thousands in many higher organisms. The first observations indicating that th
Externí odkaz:
https://doaj.org/article/a04613beea294797987c18edadb5f8f4
Autor:
Jose I de las Heras, Vanessa Todorow, Lejla Krečinić-Balić, Stefan Hintze, Rafal Czapiewski, Shaun Webb, Benedikt Schoser, Peter Meinke, Eric C Schirmer
Publikováno v:
De Las Heras, J I, Todorow, V, Krečinić-Balić, L, Hintze, S, Czapiewski, R, Webb, S, Schoser, B, Meinke, P & Schirmer, E C 2022, ' Metabolic, fibrotic, and splicing pathways are all altered in Emery-Dreifuss muscular dystrophy spectrum patients to differing degrees ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddac264
Emery-Dreifuss muscular dystrophy (EDMD) is a genetically and clinically variable disorder. Previous attempts to use gene expression changes find its pathomechanism were unavailing, so we here engaged a functional pathway analysis. RNA-Seq was perfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba4ec0e794cb2bd15a384020363cca4
https://doi.org/10.1101/2022.05.20.492778
https://doi.org/10.1101/2022.05.20.492778
Publikováno v:
Spanish Journal of Agricultural Research, Vol 11, Iss 3, Pp 708-713 (2013)
This study aimed to assess the possible relationship between the presence of Israeli acute paralysis virus (IAPV) of honeybees and disease symptoms development at the colony level, to describe the IAPV load in field colonies and to illustrate phyloge
Externí odkaz:
https://doaj.org/article/81c76aeb07cb4ec78fba3cc6f1ed686c
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127712 (2015)
Recent work indicates that the nuclear envelope is a major signaling node for the cell that can influence tissue differentiation processes. Here we present two nuclear envelope trans-membrane proteins TMEM120A and TMEM120B that are paralogs encoded b
Externí odkaz:
https://doaj.org/article/e2e861eb9925477c807370bf129105d0
Autor:
Greg J. Towers, Eleanor Gaunt, Natalia Saiz-Ros, A. Christine Richardson, David A. Kelly, Jose I. de las Heras, Eric C. Schirmer, Charles R. Dixon, Poonam Malik, Weidong Yang, Juri Rappsilber, Mark Tingey, Martin W. Goldberg, Flavia de Lima Alves, Paul Digard
Publikováno v:
Dixon, C, Malik, P, de las Heras, J, Saiz ros, N, Alves, F L, Tingey, M, Gaunt, E, Richardson, A C, Kelly, D, Goldberg, M, Towers, G J, Yang, W, Rappsilber, J, Digard, P & Schirmer, E C 2021, ' STING Nuclear Partners Contribute to Innate Immune Signalling Responses ', iScience . https://doi.org/10.1016/j.isci.2021.103055
iScience, Vol 24, Iss 9, Pp 103055-(2021)
iScience
iScience, 2021, Vol.24(9) [Peer Reviewed Journal]
iScience, Vol 24, Iss 9, Pp 103055-(2021)
iScience
iScience, 2021, Vol.24(9) [Peer Reviewed Journal]
Summary STimulator of INterferon Genes (STING) is an adaptor for cytoplasmic DNA sensing by cGAMP/cGAS that helps trigger innate immune responses (IIRs). Although STING is mostly localized in the ER, we find a separate inner nuclear membrane pool of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b5722e4a4f0e8e3aae8d553bcc61b4
https://www.pure.ed.ac.uk/ws/files/226478012/1_s2.0_S2589004221010233_main.pdf
https://www.pure.ed.ac.uk/ws/files/226478012/1_s2.0_S2589004221010233_main.pdf