Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer.

Autor: Nargund AM; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Xu C; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Mandoli A; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Okabe A; Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan., Chen GB; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Huang KK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Sheng T; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.; Department of Biochemistry, National University of Singapore, Singapore, Singapore., Yao X; Institute of Molecular and Cell Biology, Singapore, Singapore., Teo JMN; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Sundar R; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.; Department of Hematology-Oncology, National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Kok YJ; Bioprocessing Technology Institute, Singapore, Singapore., See YX; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Xing M; Epigenetic and Epitranscriptomic Regulation, Genome Institute of Singapore, Singapore, Singapore., Li Z; Division of Medical Science, Laboratory of Cancer Epigenome, National Cancer Center, Singapore, Singapore., Yong CH; Division of Medical Science, Laboratory of Cancer Epigenome, National Cancer Center, Singapore, Singapore., Anand A; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., A I ZF; Bioprocessing Technology Institute, Singapore, Singapore., Poon LF; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Ng MSW; Institute of Molecular and Cell Biology, Singapore, Singapore., Koh JYP; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Ooi WF; Epigenetic and Epitranscriptomic Regulation, Genome Institute of Singapore, Singapore, Singapore., Tay ST; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Ong X; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Tan ALK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Grabsch HI; Department of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.; Division of Pathology and Data Analytics, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom., Fullwood MJ; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Teh TB; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.; Division of Medical Science, Laboratory of Cancer Epigenome, National Cancer Center, Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre, Singapore, Singapore., Bi X; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.; Bioprocessing Technology Institute, Singapore, Singapore., Kaneda A; Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan., Li S; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tan P; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.; Epigenetic and Epitranscriptomic Regulation, Genome Institute of Singapore, Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre, Singapore, Singapore.

Publikováno v: Cancer research [Cancer Res] 2022 Jul 18; Vol. 82 (14), pp. 2538-2551.