Výsledky vyhledávání - "A I Loaiza-Pérez"

Cancer stem cells: Culprits in endocrine resistance and racial disparities in breast cancer outcomes

Autor: Andrea I. Loaiza-Pérez, Jonathan V. Wooten, Melissa Davis, Nicole Mavingire, Petreena Campbell, Eileen Brantley, Joyce Aja

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Cancer Lett

Breast cancer stem cells (BCSCs) promote endocrine therapy (ET) resistance, also known as endocrine resistance in hormone receptor (HR) positive breast cancer. Endocrine resistance occurs via mechanisms that are not yet fully understood. In vitro, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd8f57b4b3ea8ea7c91d9210abf7f51
https://www.sciencedirect.com/science/article/abs/pii/S0304383520306649

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New treatments in renal cancer: The AhR ligands

Autor: Eduardo Omar Sandes, Andrea I. Loaiza-Pérez, Lyudmila Turyanska, Boris Itkin, Alastair F. Breen, Tracey D. Bradshaw

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
International Journal of Molecular Sciences, Vol 21, Iss 3551, p 3551 (2020)
International Journal of Molecular Sciences

Kidney cancer rapidly acquires resistance to antiangiogenic agents, such as sunitinib, developing an aggressive migratory phenotype (facilitated by c-Metsignal transduction). The Aryl hydrocarbon receptor (AhR) has recently been postulated as a molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e49b79d9f8cf56df4c49795e4afd81

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AhR ligand aminoflavone suppresses α6‐integrin–Src–Akt signaling to attenuate tamoxifen resistance in breast cancer cells

Autor: Fiorella Cavalli, Melissa Davis, Olayemi O. Adeoye, Salma Khan, Jonathan V. Wooten, Rachel Schiff, Leah K. Rowland, Anna Opoku‐Agyeman, Eileen Brantley, Brittany D. Jenkins, Andrea I. Loaiza-Pérez, Gayathri Nagaraj, Petreena Campbell, Nicole Mavingire, Ubaldo Soto, Ashley Guevara, Laura Denham

Publikováno v: Journal of Cellular Physiology. 234:108-121

More than 40% of patients with luminal breast cancer treated with endocrine therapy agent tamoxifen demonstrate resistance. Emerging evidence suggests tumor initiating cells (TICs) and aberrant activation of Src and Akt signaling drive tamoxifen resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a541b057d036120a27076547fc81462
https://doi.org/10.1002/jcp.27013

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Akademický článek

The Role of Aryl Hydrocarbon Receptor and Crosstalk with Estrogen Receptor in Response of Breast Cancer Cells to the Novel Antitumor Agents Benzothiazoles and Aminoflavone

Autor: Mariana A. Callero, Andrea I. Loaiza-Pérez

Publikováno v: International Journal of Breast Cancer, Vol 2011 (2011)

Many estrogen-receptor- (ER-) expressing breast cancers become refractory to ER-based therapies. New antitumor drugs like aminoflavone (AF) and benzothiazoles (Bzs) have been developed and have exquisite antitumor activity in ER+MCF-7 and T47D cells

Externí odkaz: https://doaj.org/article/7573c3df05f14543ad8cae8024e3a288

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AhR ligand Aminoflavone inhibits α6-integrin expression and breast cancer sphere-initiating capacity

Autor: Marina Simian, Andrea I. Loaiza-Pérez, Eileen Brantley, Ubaldo Soto, Louisa Amis, Michael Yee, Laura B. Todaro, Damian E. Berardi, Mariana A. Callero, Leah K. Rowland, Dain Zylstra, Petreena Campbell

Publikováno v: Cancer letters. 376(1)

Traditional chemotherapies debulk tumors but fail to produce long-term clinical remissions due to their inability to eradicate tumor-initiating cells (TICs). This necessitates therapy with activity against the TIC niche. Αlpha6-integrin (α6-integri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5f5c9f60caa8d39af4eb0e0aa0eddd
https://pubmed.ncbi.nlm.nih.gov/26996297

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Aryl hydrocarbon receptor activation of an antitumor aminoflavone: Basis of selective toxicity for MCF-7 breast tumor cells

Autor: Andrea I. Loaiza-Pérez, Susan Kenney, Jamie Boswell, Melinda Hollingshead, Michael C. Alley, Curtis Hose, Henry P. Ciolino, Grace C. Yeh, Jane B. Trepel, David T. Vistica, Edward A. Sausville

Publikováno v: Molecular Cancer Therapeutics. 3:715-725

Aminoflavone (4H-1-benzopyran-4-one, 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methyl; NSC 686288) demonstrates differential antiproliferative activity in the National Cancer Institute's anticancer drug screen. We demonstrate here that MCF-7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bb17dbf452ed9c2fdc0ec583e58cfd4
https://doi.org/10.1158/1535-7163.715.3.6

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Hexachlorobenzene, a Dioxin-Type Compound, Increases Malic Enzyme Gene Transcription through a Mechanism Involving the Thyroid Hormone Response Element1

Autor: A M Ferramola de Sancovich, Pilar Santisteban, H A Sancovich, Andrea Randi, A I Loaiza-Pérez, M Seisdedos, D. L. Kleiman de Pisarev

Publikováno v: Endocrinology. 140:4142-4151

Hexachlorobenzene (HCB) is a dioxin-type chemical that acts mainly through the aryl hydrocarbon receptor. Chronic exposure of rats to HCB increases the activity of malic enzyme (ME). In this report, we show that this increase is correlated with an in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddadab58c64009d068d46d3c6a665bd8
https://doi.org/10.1210/endo.140.9.6996

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Aryl hydrocarbon receptor activation by aminoflavone: New molecular target for renal cancer treatment

Autor: Guadalupe Verónica Suarez, Boris Itkin, Binh T. Nguyen, Andrea I. Loaiza-Pérez, Mariana A. Callero, Gabriela Luzzani

Publikováno v: International Journal of Oncology.

Aminoflavone (AF; NSC 686288, AFP464, NSC710464) is a new anticancer drug that has recently entered phase II clinical trials. It has demonstrated antiproliferative effects in MCF-7 human breast cancer cells mediated by the aryl hydrocarbon receptor (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75374009d544e5faa0df9ccdb13690bc
https://doi.org/10.3892/ijo.2012.1427

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The role of aryl hydrocarbon receptor and crosstalk with estrogen receptor in response of breast cancer cells to the novel antitumor agents benzothiazoles and aminoflavone

Autor: Andrea I. Loaiza-Pérez, Mariana A. Callero

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
International Journal of Breast Cancer, Vol 2011 (2011)
International Journal of Breast Cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7a6b0be521bb306f8eb5b23bdb251c
https://www.hindawi.com/journals/ijbc/2011/923250/

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Targeting Histone Deacetylase as a Strategy for Cancer Prevention

Autor: Sunmin Lee, Ho Jung Oh, Eun Joo Chung, Andrea I. Loaiza-Pérez, Jane Trepel, Edward A. Sausville

Publikováno v: Cancer Chemoprevention ISBN: 9781617373428

Histone proteins were identified in 1884 (1). For many years, the material that encoded genetic diversity was believed to consist of histones (2). Posttranslational modification of histones by acetylation, and detection of histone deacetylase (HDAC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fef49a40fc8d2b2b39e182e2109e07b4
https://doi.org/10.1007/978-1-59259-767-3_43

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