Zobrazeno 1 - 10
of 542
pro vyhledávání: '"A Haspels"'
In large-scale data analysis, near-duplicates are often a problem. For example, with two near-duplicate phishing emails, a difference in the salutation (Mr versus Ms) is not essential, but whether it is bank A or B is important. The state-of-the-art
Externí odkaz:
http://arxiv.org/abs/2308.12134
Autor:
Alba Muniesa-Vargas, Carlota Davó-Martínez, Cristina Ribeiro-Silva, Melanie van der Woude, Karen L. Thijssen, Ben Haspels, David Häckes, Ülkem U. Kaynak, Roland Kanaar, Jurgen A. Marteijn, Arjan F. Theil, Maayke M. P. Kuijten, Wim Vermeulen, Hannes Lans
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Congenital nucleotide excision repair (NER) deficiency gives rise to several cancer-prone and/or progeroid disorders. It is not understood how defects in the same DNA repair pathway cause different disease features and severity. Here, we sho
Externí odkaz:
https://doaj.org/article/93db3bf48b4e441887ae6a50279dcc97
Autor:
Ben Haspels, Maayke M.P. Kuijten
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103250- (2024)
Summary: The use of 3D cancer models to study therapy response has a great advantage over conventional 2D cell culture. Here, we present an optimized protocol for breast cancer spheroid and rod-shaped microtissue formation using MicroTissues mold sys
Externí odkaz:
https://doaj.org/article/24a84178ffdf48739801fb9530fb2738
Autor:
Manzhi Zhao, Ling Li, Caoimhe H. Kiernan, Melisa D. Castro Eiro, Floris Dammeijer, Marjan van Meurs, Inge Brouwers-Haspels, Merel E. P. Wilmsen, Dwin G. B. Grashof, Harmen J. G. van de Werken, Rudi W. Hendriks, Joachim G. Aerts, Yvonne M. Mueller, Peter D. Katsikis
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Cytotoxic CD8 + T cell (CTL) exhaustion is driven by chronic antigen stimulation. Reversing CTL exhaustion with immune checkpoint blockade (ICB) has provided clinical benefits in different types of cancer. We, therefore, investigated whether
Externí odkaz:
https://doaj.org/article/894d1a0cf952487080d6943e463aba2e
Autor:
Babette Verkouteren, Dan Piña-Fuentes, Martijn Beudel, Thomas Ludden, Rik H G Olde Engberink, Tom Dormans, Martijn D de Kruif, Suat Simsek, Joop P van den Bergh, Hazra Moeniralam, Renee Douma, Kees Brinkman, Wouter Hinsenveld, Lucas Ramos, Anne Pirson, Deborah Hubers, Shi Hu, Rajat Thomas, Michiel Schinkel, Caroline E Wyers, Daisy Rusch, Lianne de Haan, Niels C Gritters van den Oever, Nienke Paternotte, Robert-Jan Goldhoorn, Brent Appelman, Esther Lems, Marije ten Wolde, Esther K Haspels-Hogervorst, Neyma Bokhizzou, Niels Gritters van den Oever, Joop van den Bergh, Martijn de Kruif, Helen Leavis, Derk Arts, Nick Nurmohamed, Rens Reeskamp, Willem Herter, Bas Vonk, Ricardo Lopes, Deborah Huberts, Marije Wolfers, Sander de Kuij, Sophie Noordzij, Sibbeliene van den Bosch, Benthe Verhoef, Michele Methorst, Shahan Darwesh, Tijn van Egmond, Gulsum Nasim, Hamza Ali, Lars de Boer, Myrthe Nagel, Maud Koenis, Agnetha Bijlsma, Britt Balvers, Isabella Ghauharali, Jelle de Jongh, Maira Emanuel, Nisrine Aynaou, Rosemarie de Ridder, Insaff Darraz, Oumaima Darraz, Alanar Cinar, Jesse Roosen, Larissa Heideman, Asabi Leliveld, Dana Ruijter, Neeltje Rosenberg, Djoeke Woutman, Tom Vermeulen, Sam de Joode, Willem Berger, Ozgu Varan, Soesja Pinto, Sientje Sluis, Bibi Kuiper, Tim van der Putten, Dominique Bosje, Mahunda Sinyangwe, Roos van Rhijn, Koen Kruif, Miriam den Heijer, Koen de Kruijf, Sam Hofhuis, Gwendolyn Telting, Susan van der Lei, Pien van Paassen, Emil ter Veer, Krijna Opschoor, Camille Breukhoven, Florine Jiwa, Peter de Gooyer, Jan Vrijdag, Stans van Gelder, Anne Pannekoek, Laura Dommershuijzen, Estelle Adang, Maud van Maren, Isabel Koop, Bart Sanders, Joukje Wanten, Dax Trommelen, Fleur Smeets, Kyra Heuvelings, Maud Cox, Milou Rademaekers, Vivian Hendrikx, Ilona van Rooij, Wendy Heuts, Laura Oudeman, Evelien Brans, Karin Slot, Kirsten Boerma-Argelo, Wilma Kok, Lieke Harmsen, Ingrid Boerema, Anne Raafs, Anne Smaal, Bibiane Pop, Carmen Waterink, Casper Vrij, Daphne van der Willik, Frederic Reitsma, Imogene Pieters, Jade Logger, Laura Sijben, Maikel Peeters, Mariël Teunissen, Marije Blok-Hoos, Marjolein Ketels, Michiel Henkens, Mireille Spanjers, Monique Jacob-Dols, Patrick de Hoogt, Rik Houben, Roos van Gorp, Josien Jansen
Publikováno v:
BMJ Open, Vol 13, Iss 11 (2023)
Objectives To evaluate the relationship among dysnatraemia at hospital presentation and duration of admission, risk of intensive care unit (ICU) admission and all-cause mortality and to assess the underlying pathophysiological mechanism of hyponatrae
Externí odkaz:
https://doaj.org/article/fad6410fff844b2180af17e45d668c56
Autor:
Ling Li, Manzhi Zhao, Caoimhe H. Kiernan, Melisa D. Castro Eiro, Marjan van Meurs, Inge Brouwers-Haspels, Merel E. P. Wilmsen, Dwin G. B. Grashof, Harmen J. G. van de Werken, Rudi W. Hendriks, Yvonne M. Mueller, Peter D. Katsikis
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionCytotoxic CD8+ T cell (CTL) exhaustion is a dysfunctional state of T cells triggered by persistent antigen stimulation, with the characteristics of increased inhibitory receptors, impaired cytokine production and a distinct transcriptiona
Externí odkaz:
https://doaj.org/article/3847fcbb75c24886b8cbbde00a41f92f
Autor:
Gerharda H. Boerman, MD, Heleen N. Haspels, MSc, Matthijs de Hoog, MD, PhD, Koen F. Joosten, MD, PhD
Publikováno v:
Critical Care Explorations, Vol 5, Iss 9, p e0971 (2023)
OBJECTIVES:. To examine the characteristics of long-stay patients (LSPs) admitted to a PICU and to investigate discharge characteristics of medical complexity among discharged LSP. DESIGN:. We performed a retrospective cohort study where clinical dat
Externí odkaz:
https://doaj.org/article/046448515d5b4705944cd7bc805fe6ec
Autor:
Popping, Stephanie1,2 (AUTHOR) s.popping@erasmusmc.nl, Haspels, Sabine1 (AUTHOR), Gotz, Hannelore M.3 (AUTHOR), van der Meijden, W. C. J. P. M.4 (AUTHOR), van den Elshout, Mark5 (AUTHOR), Rijnders, Bart J.1 (AUTHOR) s.popping@erasmusmc.nl
Publikováno v:
Viruses (1999-4915). Dec2023, Vol. 15 Issue 12, p2317. 6p.
Autor:
Lisa Geertjens, Gianina Cristian, Eva Haspels, Jennifer Ramautar, Gert Jan van der Wilt, Matthijs Verhage, Hilgo Bruining
Publikováno v:
BMC Psychiatry, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Bumetanide is a selective NKCC1 chloride importer antagonist which is being repurposed as a mechanism-based treatment for neurodevelopmental disorders (NDDs). Due to their specific actions, these kinds of interventions will only b
Externí odkaz:
https://doaj.org/article/42eab36f1f0f4a5d82debdf59f306c57
Autor:
Haspels, Heleen N.1,2 (AUTHOR), de Lange, Annemieke A.3 (AUTHOR), Alsem, Mattijs W.3,4 (AUTHOR), Sandbergen, Bettina5 (AUTHOR), Dulfer, Karolijn2 (AUTHOR), de Hoog, Matthijs2 (AUTHOR), Joosten, Koen F. M.2 (AUTHOR), van Karnebeek, Clara D.6 (AUTHOR), van Woensel, Job B. M.1 (AUTHOR), Maaskant, Jolanda M.3 (AUTHOR) j.m.maaskant@amsterdamumc.nl
Publikováno v:
European Journal of Pediatrics. Sep2023, Vol. 182 Issue 9, p3833-3843. 11p. 1 Diagram, 3 Charts.