Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing

Autor: Ariana Hirsh, Robert Dullea, Meihua Tu, Spiros Liras, Joan Compte Barrón, Kris A. Borzilleri, Nannan Ma, Rima Mendonsa, Justin Bellenger, Romain Rouet, Lorena de Oñate, Xidong Feng, Jennifer A. Doudna, Nathanael G. Lintner, David M. Rubitski, Benjamin A. Thuma, Marc D. Roy, Alison H. Varghese, Kim F. McClure, Ross C. Wilson, Thomas J. McLellan, Hanna M. Wisniewska, James E. Finley, Boris A. Chrunyk, Vincent Mascitti, Kaihong Zhou, Kevin D. Hesp

Publikováno v: Journal of the American Chemical Society, vol 140, iss 21
Rouet, Romain; Thuma, Benjamin A; Roy, Marc D; Lintner, Nathanael G; Rubitski, David M; Finley, James E; et al.(2018). Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing.. Journal of the American Chemical Society, 140(21), 6596-6603. doi: 10.1021/jacs.8b01551. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/61k3t664

CRISPR-Cas RNA-guided endonucleases hold great promise for disrupting or correcting genomic sequences through site-specific DNA cleavage and repair. However, the lack of methods for cell- and tissue-selective delivery currently limits both research a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af967c5dc058dcd0e0a6cfe05eb8b81
https://doi.org/10.1021/jacs.8b01551

Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design

Autor: Christopher John Helal, Kevin Atchison, Christopher Ryan Butler, Cathleen Gonzales, Ricardo Lira, Shawn D. Doran, Feng Pan, Felix Vajdos, Alison H. Varghese, Gabriela Barreiro, Michael Aaron Brodney, Jinlong Wang, Elizabeth Mary Beck, Luis Martinez-Alsina, Yong Zhang, Kevin D. Parris, David Riddell, Joseph Michael Young, Leanne M. Buzon, Ashley Robshaw, Kevin Ogilvie, Jason K. Dutra, Brian T. O’Neill, John C. Murray, Charles E. Nolan

Publikováno v: Journal of Medicinal Chemistry. 58:2678-2702

The identification of centrally efficacious β-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease (AD) has historically been thwarted by an inability to maintain alignment of potency, brain availability, and desired absorption, dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455eb0d85337e81623d88cc6b235a8b0
https://doi.org/10.1021/jm501833t

Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism

Autor: Inish O'Doherty, Brandon Pabst, Adam M. Gilbert, Kimberly F. Fennell, Chris Limberakis, Jinshan Chen, Jayvardhan Pandit, Matthew Frank Brown, Markus Boehm, Rushi Patel, Jeffrey A. Pfefferkorn, Jemy A. Gutierrez, Robert M. Oliver, Jiangli Yan, Jeremy T. Starr, Kay Ahn, Brandon P. Schuff, Amit S. Kalgutkar, Kieran F. Geoghegan, Kevin D. Parris, Veerabahu Shanmugasundaram, Cecile Vernochet, Timothy P. Rolph, Ye Che, Nicholas B. Vera, Alison H. Varghese, Adhiraj Lanba, Magee Thomas Victor, Jessica Calloway

Publikováno v: ACS chemical biology. 11(9)

Lysophospholipase-like 1 (LYPLAL1) is an uncharacterized metabolic serine hydrolase. Human genome-wide association studies link variants of the gene encoding this enzyme to fat distribution, waist-to-hip ratio, and nonalcoholic fatty liver disease. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8faf739c4bd62a7e0dc07d74faa9aee9
https://pubmed.ncbi.nlm.nih.gov/27391855

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

Autor: Jane M. Withka, David A. Griffith, John E. Bleasdale, Declan Flynn, Brian J. Stockman, Pat Loulakis, Kay Ahn, Xiayang Qiu, Jessica Ward, David Cunningham, Venkataraman Thanabal, Michelle Pacholec, Alison H. Varghese, Brandon Pabst, Boris A. Chrunyk, Robert S. Garofalo, Matt Griffor

Publikováno v: Journal of Biological Chemistry. 285:8340-8351

Sirtuins catalyze NAD(+)-dependent protein deacetylation and are critical regulators of transcription, apoptosis, metabolism, and aging. There are seven human sirtuins (SIRT1-7), and SIRT1 has been implicated as a key mediator of the pathways downstr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce433ade6151df51a9b60b2e829af876
https://doi.org/10.1074/jbc.m109.088682

Influence of the chemical structure of polycarbonates on the contribution of crosslinking and chain scissions to the photothermal ageing

Autor: Jean-Luc Gardette, Jérémie Soulestin, H. Varghese, Bénédicte Mailhot, Agnès Rivaton

Publikováno v: European Polymer Journal
European Polymer Journal, Elsevier, 2002, 38 (7), pp.1349-1363. ⟨10.1016/S0014-3057(01)00307-X⟩
European Polymer Journal, 2002, 38 (7), pp.1349-1363. ⟨10.1016/S0014-3057(01)00307-X⟩

International audience; The relative importance of crosslinking and chain scissions reactions involved in the photothermal ageing of polycarbonates is shown to depend on the chemical structure of the polymer. The orientation of these reactions is lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec74ecb5ecd359778f845b568b6f00e
https://doi.org/10.1016/s0014-3057(01)00307-x