Výsledky vyhledávání - "A H, Penninks"

Integration of efficacy, pharmacokinetic and safety assessment of interleukin-1 receptor antagonist in a preclinical model of arthritis

Autor: Anne-Marie Zuurmond, Nicole H.P. Cnubben, Jolanda H. M. van Bilsen, Benno van El, Robert Doornbos, Jacqueline Bastiaans, A. Koudijs, Jeroen DeGroot, Babs C.T. van Manen-Vernooij, André H. Penninks

Publikováno v: Regulatory Toxicology and Pharmacology. 59:461-470

Pharmacokinetic properties and safety profile of a drug are likely influenced by the disease state of a patient. In this study, we investigated the influence of arthritic processes on pharmacokinetics and immunotoxicity of interleukin-1 receptor anta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce1d59e059e01509c0195cb80ad3242
https://doi.org/10.1016/j.yrtph.2011.01.014

Zobrazit plný text záznamu

Comparison of antibody responses to hen's egg and cow's milk proteins in orally sensitized rats and food-allergic patients

Autor: L.M.J. Knippels, H.P.M. van der Kleij, S. J. Koppelman, G. F. Houben, A. H. Penninks, A.A. Felius

Publikováno v: Allergy. 55:251-258

Background: No adequate enteral sensitization models are available to study food allergy and the allergenicity of food proteins. To further validate an enteral brown Norway (BN) rat sensitization model under development, we studied specific protein r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e83209daa5679b11017e7de0952a9b
https://doi.org/10.1034/j.1398-9995.2000.00403.x

Zobrazit plný text záznamu

Comparative study of the nutritive value of casein heated by microwave and conventionally

Autor: André H Penninks, Diana Jonker

Publikováno v: Journal of the Science of Food and Agriculture. 59:123-126

The objective of this study was to compare the net protein utilisation, digestibility and biological value of casein solution heated by microwave or conventionally, ie on an electrically heated plate. Portions (500 ml) of an aqueous solution of casei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0539629ef18d2f8490fe97313a14c25d
https://doi.org/10.1002/jsfa.2740590118

Zobrazit plný text záznamu

The range of minimum provoking doses in hazelnut-allergic patients as determined by double-blind, placebo-controlled food challenges

Autor: M, Wensing, A H, Penninks, S L, Hefle, J H, Akkerdaas, R, van Ree, S J, Koppelman, C A F M, Bruijnzeel-Koomen, A C, Knulst

Publikováno v: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 32(12)

The risk for allergic reactions depends on the sensitivity of individuals and the quantities of offending food ingested. The sensitivity varies among allergic individuals, as does the threshold dose of a food allergen capable of inducing an allergic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fdbd0e5848a90272338981caae77cff1
https://pubmed.ncbi.nlm.nih.gov/12653168

Zobrazit plný text záznamu

Assessment of protein allergenicity: studies in brown norway rats

Autor: Léon M J, Knippels, André H, Penninks

Publikováno v: Annals of the New York Academy of Sciences. 964

For the safety evaluation of genetically engineered crops, the potential allergenicity of the newly introduced protein(s) has become an important issue. There is, however, no universal and reliable test system for the evaluation of the allergic sensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::918548df3f156b3beb0eccaea2cd45ba
https://pubmed.ncbi.nlm.nih.gov/12023202

Zobrazit plný text záznamu

Food allergen (peanut)-specific TH2 clones generated from the peripheral blood of a patient with peanut allergy

Autor: E C, de Jong, S, Spanhaak, B P, Martens, M L, Kapsenberg, A H, Penninks, E A, Wierenga

Publikováno v: The Journal of allergy and clinical immunology. 98(1)

Increasing evidence indicates a prominent role of allergen-specific TH2 cells, with high IL-4 and IL-5 production and low interferon-gamma production, in the regulation of IgE and eosinophil production in allergic disorders. However, most studies hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38708e0245c0381c5ea5ca9966dd704c
https://pubmed.ncbi.nlm.nih.gov/8765820

Zobrazit plný text záznamu

The evaluation of data-derived safety factors for bis(tri-n-butyltin)oxide

Autor: Andre H. Penninks

Publikováno v: Food additives and contaminants. 10(3)

In this report the evaluation of a safety factor is assessed, according to the decision tree suggested by Renwick (1991a,b), to determine a Tolerable Daily Intake (TDI) value for the environmental contaminant bis(tri-n-butyltin)oxide (TBTO). Based on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79995758855775248d06bc66d7fa7a6
https://pubmed.ncbi.nlm.nih.gov/8359316

Zobrazit plný text záznamu

Recovery from chemically induced thymus atrophy starts with CD4- CD8- CD2high TcR alpha beta-/low thymocytes and results in an increased formation of CD4- CD8- TcR alpha beta high thymocytes

Autor: R H, Pieters, M, Bol, B W, Lam, W, Seinen, N, Bloksma, A H, Penninks

Publikováno v: Immunology. 78(4)

Regeneration of the thymus was studied in rats that were treated with a single oral dose of the organotin compound di-n-butyltin dichloride (DBTC). After an initial maximum depletion of cortical BrdU+ thymocytes on day 2 after treatment, repopulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::760063bd0ed1658f87f67a7952ddef88
https://pubmed.ncbi.nlm.nih.gov/8098700

Zobrazit plný text záznamu

The organotin-induced thymus atrophy, characterized by depletion of CD4+ CD8+ thymocytes, is preceded by a reduction of the immature CD4- CD8+ TcR alpha beta-/low CD2high thymoblast subset

Autor: R H, Pieters, M, Bol, B W, Lam, W, Seinen, A H, Penninks

Publikováno v: Immunology. 76(2)

Thymic changes in the rat induced by the thymus atrophy-inducing organotin compound di-n-butyltin dichloride (DBTC) were examined using FACS analyses. The number of CD4+CD8+ thymocytes was reduced by DBTC treatment from Day 2 onwards and reached mini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5932aa1d873ea6678b15b4998774f3a9
https://pubmed.ncbi.nlm.nih.gov/1353062

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání