Zobrazeno 1 - 10
of 242
pro vyhledávání: '"A H, Guse"'
Autor:
Sarah Krukenberg, Franziska Möckl, Mariella Weiß, Patrick Dekiert, Melanie Hofmann, Fynn Gerlach, Kai J. Winterberg, Dejan Kovacevic, Imrankhan Khansahib, Berit Troost, Macarena Hinrichs, Viviana Granato, Mikolaj Nawrocki, Tobis Hub, Volodymyr Tsvilovskyy, Rebekka Medert, Lena-Marie Woelk, Fritz Förster, Huan Li, René Werner, Marcus Altfeld, Samuel Huber, Oliver Biggs Clarke, Marc Freichel, Björn-Philipp Diercks, Chris Meier, Andreas H. Guse
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Upon stimulation of membrane receptors, nicotinic acid adenine dinucleotide phosphate (NAADP) is formed as second messenger within seconds and evokes Ca2+ signaling in many different cell types. Here, to directly stimulate NAADP signaling, M
Externí odkaz:
https://doaj.org/article/fcb6cf2df7404754829e9ef6c09deac4
Autor:
Stephan Menzel, Yinghui Duan, Julia Hambach, Birte Albrecht, Dorte Wendt-Cousin, Riekje Winzer, Eva Tolosa, Anne Rissiek, Andreas H. Guse, Friedrich Haag, Tim Magnus, Friedrich Koch-Nolte, Björn Rissiek
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
CD39 is the major enzyme controlling the levels of extracellular adenosine triphosphate (ATP) via the stepwise hydrolysis of ATP to adenosine diphosphate (ADP) and adenosine monophosphate (AMP). As extracellular ATP is a strong promoter of inflammati
Externí odkaz:
https://doaj.org/article/ede936c25e8b4acd80c5bcc8d2044e79
Autor:
Valerie J. Brock, Niels Christian Lory, Franziska Möckl, Melina Birus, Tobias Stähler, Lena-Marie Woelk, Michelle Jaeckstein, Joerg Heeren, Friedrich Koch-Nolte, Björn Rissiek, Hans-Willi Mittrücker, Andreas H. Guse, René Werner, Björn-Philipp Diercks
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
CD8+ T cells are a crucial part of the adaptive immune system, responsible for combating intracellular pathogens and tumor cells. The initial activation of T cells involves the formation of highly dynamic Ca2+ microdomains. Recently, purinergic signa
Externí odkaz:
https://doaj.org/article/a2847c04e466468e97ea1424969ec6f1
Autor:
Andrea Benzi, Markus Heine, Sonia Spinelli, Annalisa Salis, Anna Worthmann, Björn Diercks, Cecilia Astigiano, Raúl Pérez Mato, Adela Memushaj, Laura Sturla, Valerio Vellone, Gianluca Damonte, Michelle Y. Jaeckstein, Friedrich Koch-Nolte, Hans-Willi Mittrücker, Andreas H. Guse, Antonio De Flora, Joerg Heeren, Santina Bruzzone
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2024)
IntroductionDuring thermogenesis, adipose tissue (AT) becomes more active and enhances oxidative metabolism. The promotion of this process in white AT (WAT) is called “browning” and, together with the brown AT (BAT) activation, is considered as a
Externí odkaz:
https://doaj.org/article/6cbc007a0f474be38c4530fd56e6e433
Autor:
Jelena Pick, Simon Sander, Stefanie Etzold, Anette Rosche, Henning Tidow, Andreas H. Guse, Ralf Fliegert
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
TRPM2 is a Ca2+ permeable, non-selective cation channel in the plasma membrane that is involved in the innate immune response regulating, for example, chemotaxis in neutrophils and cytokine secretion in monocytes and macrophages. The intracellular ad
Externí odkaz:
https://doaj.org/article/c5740e9dda0c4bb5b4009932a290188e
Autor:
Lena-Marie Woelk, Dejan Kovacevic, Hümeyra Husseini, Fritz Förster, Fynn Gerlach, Franziska Möckl, Marcus Altfeld, Andreas H. Guse, Björn-Philipp Diercks, René Werner
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Ca2+ microdomains play a key role in intracellular signaling processes. For instance, they mediate the activation of T cells and, thus, the initial adaptive immune system. They are, however, also of utmost importance for activation of other cells, an
Externí odkaz:
https://doaj.org/article/4cd49f80fa774343bc5f04ae62b8b9b2
Autor:
Diana C. Gil Montoya, Roberto Ornelas-Guevara, Björn-Philipp Diercks, Andreas H. Guse, Geneviève Dupont
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cellular Ca2+ signaling is highly organized in time and space. Locally restricted and short-lived regions of Ca2+ increase, called Ca2+ microdomains, constitute building blocks that are differentially arranged to create cellular Ca2+ signatures contr
Externí odkaz:
https://doaj.org/article/b5f55d5d17e74a64b47835ab29914406
Autor:
Laura Garcia Perez, Jan Kempski, Heather M. McGee, Penelope Pelzcar, Theodora Agalioti, Anastasios Giannou, Leonie Konczalla, Leonie Brockmann, Ramez Wahib, Hao Xu, Maria Carolina Amezcua Vesely, Shiwa Soukou, Babett Steglich, Tanja Bedke, Carolin Manthey, Oliver Seiz, Björn-Philipp Diercks, Stylianos Gnafakis, Andreas H. Guse, Daniel Perez, Jakob R. Izbicki, Nicola Gagliani, Richard A. Flavell, Samuel Huber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Poly-functional helper T cells can have a stronger effect than mono-functional T cells, but whether the response is qualitatively different is not clear. Here the authors show that a population of IL-17+IL-22+, but not single IL-22+, CD4+ T cells are
Externí odkaz:
https://doaj.org/article/b2cd0a9890934f83bc2a0f45b98be1cc
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Ca2+ signalling plays an essential role in T cell activation, which is a key step to start an adaptive immune response. During the transition from a quiescent to a fully activated state, Ca2+ microdomains of reduced spatial and temporal extents devel
Externí odkaz:
https://doaj.org/article/c3fe2eef22664b2d9821c342def5d6e8
Autor:
Niels C. Lory, Mikolaj Nawrocki, Martina Corazza, Joanna Schmid, Valéa Schumacher, Tanja Bedke, Stephan Menzel, Friedrich Koch-Nolte, Andreas H. Guse, Samuel Huber, Hans-Willi Mittrücker
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Antigen recognition by the T-cell receptor induces a cytosolic Ca2+ signal that is crucial for T-cell function. The Ca2+ channel TRPM2 (transient receptor potential cation channel subfamily M member 2) has been shown to facilitate influx of extracell
Externí odkaz:
https://doaj.org/article/5c28e5bc8b0942f7974a02595a93de41