Zobrazeno 1 - 10
of 86
pro vyhledávání: '"A H, Andreotti"'
Autor:
Amy H Andreotti, Volker Dötsch
Publikováno v:
eLife, Vol 13 (2024)
The articles in this special issue highlight how modern cellular, biochemical, biophysical and computational techniques are allowing deeper and more detailed studies of allosteric kinase regulation.
Externí odkaz:
https://doaj.org/article/cb5cc8395dcb4de98003bbf5c11a5cd3
Autor:
David Yin-wei Lin, Lauren E Kueffer, Puneet Juneja, Thomas E Wales, John R Engen, Amy H Andreotti
Publikováno v:
eLife, Vol 12 (2024)
Full-length Bruton’s tyrosine kinase (BTK) has been refractory to structural analysis. The nearest full-length structure of BTK to date consists of the autoinhibited SH3–SH2–kinase core. Precisely how the BTK N-terminal domains (the Pleckstrin
Externí odkaz:
https://doaj.org/article/6893fa79a72b4e8bbfd35d28b126c009
Autor:
David Y. Lin, Amy H. Andreotti
Publikováno v:
PLoS ONE, Vol 18, Iss 8 (2023)
Bruton’s tyrosine kinase (BTK) is the target of the therapeutic agent, Ibrutinib, that treats chronic lymphocyte leukemia (CLL), mantle cell lymphoma (MCL) and other B cell malignancies. Ibrutinib is a first in class, covalent BTK inhibitor that li
Externí odkaz:
https://doaj.org/article/8bdc1d9f05d94e029bb577693d87b5ac
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/bf2d084e6cc141d69a489462362e6b57
Publikováno v:
Journal of Structural Biology: X, Vol 6, Iss , Pp 100061- (2022)
Cell surface receptors such as the T-cell receptor (TCR) and B-cell receptor (BCR) engage with external stimuli to transmit information into the cell and initiate a cascade of signaling events that lead to gene expression that drives the immune respo
Externí odkaz:
https://doaj.org/article/8e4f51776dd241dea5c38b325a6e6f40
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Since Dr. Ogden Bruton’s 1952 paper describing the first human primary immunodeficiency disease, the peripheral membrane binding signaling protein, aptly named Bruton’s tyrosine kinase (BTK), has been the target of intense study. Dr. Bruton’s d
Externí odkaz:
https://doaj.org/article/dac1612540c9495b93691264c444ed2f
Autor:
Manish Aryal, David Lin, Kiera Regan, Shoucheng Du, Haibin Shi, John J. Alvarado, Tatiana V. Ilina, Amy H. Andreotti, Thomas E. Smithgall
Publikováno v:
Sci Signal
The Nef protein produced by the viruses HIV-1 and SIV drives efficient viral replication partially by inducing constitutive activation of host cell tyrosine kinases, including members of the Src and Tec families. Here, we uncovered the mechanism by w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::201841cd4f1ed2035a26ee1490d80361
https://doi.org/10.1126/scisignal.abn8359
https://doi.org/10.1126/scisignal.abn8359
