Zobrazeno 1 - 10
of 382
pro vyhledávání: '"A G Wynne"'
Publikováno v:
BMC Musculoskeletal Disorders, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Background Clinical management of musculoskeletal shoulder pain can be challenging due to diagnostic uncertainty, variable prognosis and limited evidence for long-term treatment benefits. The UK-based PANDA-S programme (Prognostic And Diagno
Externí odkaz:
https://doaj.org/article/b4c5a4089e854d489ef8105242b3a8fa
Autor:
Anthony G Wynne, Charles Affourtit
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0266905 (2022)
Dietary nitrate lowers the oxygen cost of human exercise. This effect has been suggested to result from stimulation of coupling efficiency of skeletal muscle oxidative phosphorylation by reduced nitrate derivatives. In this paper, we report the acute
Externí odkaz:
https://doaj.org/article/fce61390272146b8bf6a19c971c724c5
Autor:
Michelle D. Garrett, Ian Collins, Suzanne A. Eccles, Florence I. Raynaud, Louis Chesler, John C. Reader, G. Wynne Aherne, Simon P. Robinson, Yann Jamin, Thomas P. Matthews, Michael Lainchbury, Kathy J. Boxall, Elizabeth L. Smith, Albert Hallsworth, Gary Box, Alexis K. De Haven Brandon, Melanie R. Valenti, Angela Hayes, Paul D. Eve, Mike I. Walton
Purpose: Many tumors exhibit defective cell-cycle checkpoint control and increased replicative stress. CHK1 is critically involved in the DNA damage response and maintenance of replication fork stability. We have therefore discovered a novel potent,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e3b923fa0fcf3545079b70d397c6b4
https://doi.org/10.1158/1078-0432.c.6520529
https://doi.org/10.1158/1078-0432.c.6520529
Autor:
Michelle D. Garrett, Ian Collins, Suzanne A. Eccles, Florence I. Raynaud, Louis Chesler, John C. Reader, G. Wynne Aherne, Simon P. Robinson, Yann Jamin, Thomas P. Matthews, Michael Lainchbury, Kathy J. Boxall, Elizabeth L. Smith, Albert Hallsworth, Gary Box, Alexis K. De Haven Brandon, Melanie R. Valenti, Angela Hayes, Paul D. Eve, Mike I. Walton
PDF file, 79K, Supplementary Table 3 - Mouse body weights for data in Figure 4A Body Weights expressed as a percentage of the weight on day 0 for mice bearing HT29 xenografts and treated with gemcitabine (100mg/kg iv), CCT244747 (75mg/kg po) or the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401ea57b719c1a1d93ab5881aa5484ab
https://doi.org/10.1158/1078-0432.22445615
https://doi.org/10.1158/1078-0432.22445615
Autor:
Michelle D. Garrett, Ian Collins, Suzanne A. Eccles, Florence I. Raynaud, Louis Chesler, John C. Reader, G. Wynne Aherne, Simon P. Robinson, Yann Jamin, Thomas P. Matthews, Michael Lainchbury, Kathy J. Boxall, Elizabeth L. Smith, Albert Hallsworth, Gary Box, Alexis K. De Haven Brandon, Melanie R. Valenti, Angela Hayes, Paul D. Eve, Mike I. Walton
PDF file, 92K, Supplementary Figure 2. A constrained, scaffold docking model of CCT244747 in the ATP pocket of human CHK1 realized using the SAR-020106 X-ray crystal structure (PDB 2ym8).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db6fcbdeb80531e3ddd7d42e0cafbdd
https://doi.org/10.1158/1078-0432.22445639
https://doi.org/10.1158/1078-0432.22445639
Autor:
Michelle D. Garrett, Ian Collins, John C. Reader, David H. Williams, Florence I. Raynaud, Suzanne A. Eccles, G. Wynne Aherne, Kathy J. Boxall, Gary Box, Alexis De Haven Brandon, Melanie Valenti, Angela Hayes, Paul D. Eve, Michael I. Walton
PDF file, 63KB, Kinase inhibitory profile of SAR-020106 at 10 μMa.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32afb33095afaa0235fcca7f9841e0bf
https://doi.org/10.1158/1535-7163.22485369
https://doi.org/10.1158/1535-7163.22485369
Autor:
Michelle D. Garrett, Ian Collins, Suzanne A. Eccles, Florence I. Raynaud, Louis Chesler, John C. Reader, G. Wynne Aherne, Simon P. Robinson, Yann Jamin, Thomas P. Matthews, Michael Lainchbury, Kathy J. Boxall, Elizabeth L. Smith, Albert Hallsworth, Gary Box, Alexis K. De Haven Brandon, Melanie R. Valenti, Angela Hayes, Paul D. Eve, Mike I. Walton
PDF file, 118K, Supplementary Table 2 Summary of Effects of Irinotecan, Gemcitabine and CCT244747 alone or in combination on human tumor xenografts growth delay.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1bd0e4da26aa07abae832d484513eb
https://doi.org/10.1158/1078-0432.22445618
https://doi.org/10.1158/1078-0432.22445618
Autor:
Michelle D. Garrett, Ian Collins, Suzanne A. Eccles, Florence I. Raynaud, Louis Chesler, John C. Reader, G. Wynne Aherne, Simon P. Robinson, Yann Jamin, Thomas P. Matthews, Michael Lainchbury, Kathy J. Boxall, Elizabeth L. Smith, Albert Hallsworth, Gary Box, Alexis K. De Haven Brandon, Melanie R. Valenti, Angela Hayes, Paul D. Eve, Mike I. Walton
PDF file, 810K, Supplementary Figure 3 Characterisation of the effects of minimally toxic concentrations of CCT244747 alone or in combination with genotoxic agents (+) in HT29 and SW620 colon cancer cell lines. A, HT29 cells were treated with SN38 (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343131448e94d2702194f9a5362972e1
https://doi.org/10.1158/1078-0432.22445636
https://doi.org/10.1158/1078-0432.22445636
Autor:
Michelle D. Garrett, Ian Collins, Suzanne A. Eccles, Florence I. Raynaud, Louis Chesler, John C. Reader, G. Wynne Aherne, Simon P. Robinson, Yann Jamin, Thomas P. Matthews, Michael Lainchbury, Kathy J. Boxall, Elizabeth L. Smith, Albert Hallsworth, Gary Box, Alexis K. De Haven Brandon, Melanie R. Valenti, Angela Hayes, Paul D. Eve, Mike I. Walton
PDF file, 76K, Supplementary Table 1 Kinome selectivity profile of CCT244747 CCT244747 was tested at 1 μM (140 enzymes) and 10 μM (121 enzymes) for inhibition of human kinases in a radiometric protein phosphorylation assay (MRC Protein Phosphorylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbea4bf2cbee88a83459a4ad37108cee
https://doi.org/10.1158/1078-0432.22445621.v1
https://doi.org/10.1158/1078-0432.22445621.v1
Autor:
Michelle D. Garrett, Ian Collins, Suzanne A. Eccles, Florence I. Raynaud, Louis Chesler, John C. Reader, G. Wynne Aherne, Simon P. Robinson, Yann Jamin, Thomas P. Matthews, Michael Lainchbury, Kathy J. Boxall, Elizabeth L. Smith, Albert Hallsworth, Gary Box, Alexis K. De Haven Brandon, Melanie R. Valenti, Angela Hayes, Paul D. Eve, Mike I. Walton
PDF file, 67K, Supplementary Figure 4. Effects of scheduling and exposure times on the ability of two different CHK1 inhibitors to potentiate gemcitabine cytotoxicity in SW620 cells in vitro. A, Effect of different contact times on the capacity of SA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645f855fb751a0d3f4a65c2278c348bf
https://doi.org/10.1158/1078-0432.22445633.v1
https://doi.org/10.1158/1078-0432.22445633.v1