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Akademický článek

PIP5K1α is Required for Promoting Tumor Progression in Castration-Resistant Prostate Cancer

Autor: Tianyan Wang, Martuza Sarwar, Jonathan B Whitchurch, Hilary M Collins, Tami Green, Julius Semenas, Amjad Ali, Christopher J Roberts, Ryan D Morris, Madlen Hubert, Sa Chen, Zahra El-Schich, Anette G Wingren, Thomas Grundström, Richard Lundmark, Nigel P Mongan, Lena Gunhaga, David M Heery, Jenny L Persson

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

PIP5K1α has emerged as a promising drug target for the treatment of castration-resistant prostate cancer (CRPC), as it acts upstream of the PI3K/AKT signaling pathway to promote prostate cancer (PCa) growth, survival and invasion. However, little is

Externí odkaz: https://doaj.org/article/6f00bee0afbc4bf1a1d8d8f354c3e273

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Functional characterization of the interaction between the superantigen staphylococcal enterotoxin A and the TCR

Autor: P Antonsson, A G Wingren, J Hansson, T Kalland, M Varga, M Dohlsten

Publikováno v: The Journal of Immunology. 158:4245-4251

In this report, we show that despite an overall amino acid residue identity of more than 80% between the staphylococcal enterotoxins (SE) A and E, these proteins markedly differ in their absolute requirement for the MHC class II during T cell activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f4dc1d18aebb1f805a3f5dd13727d3f
https://doi.org/10.4049/jimmunol.158.9.4245

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Prevalence and characteristics of child physical abuse in Sweden - findings from a population-based youth survey

Autor: E-M, Annerbäck, G, Wingren, C G, Svedin, P A, Gustafsson

Publikováno v: Acta paediatrica (Oslo, Norway : 1992). 99(8)

To examine prevalence rates of child physical abuse perpetrated by a parent/caretaker, abuse characteristics and the extent of disclosures.A population-based survey was carried out in 2008 amongst all the pupils in three different grades (n = 8494) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c553bf9680380b5e7152edd93d59c1e4
https://pubmed.ncbi.nlm.nih.gov/20219025

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The role of B7-1 and LFA-3 in costimulation of CD8+ T cells

Autor: E, Parra, A G, Wingren, G, Hedlund, T, Kalland, M, Dohlsten

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 158(2)

This study compares the ability of LFA-3 (CD58) and B7-1 (CD80) ligands to provide costimulatory signals for superantigen (SAg)-stimulated CD8+ and CD4+ T cells. We show that B7-1 and LFA-3 costimulation activate CD8+ T cells to proliferation, cytoki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d22c902123da2083285432f9627dec1
https://pubmed.ncbi.nlm.nih.gov/8992978

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