Zobrazeno 1 - 10
of 339
pro vyhledávání: '"A G Monroe"'
Autor:
Christine M. Hamadani, Fakhri Mahdi, Anya Merrell, Jack Flanders, Ruofan Cao, Priyavrat Vashisth, Gaya S. Dasanayake, Donovan S. Darlington, Gagandeep Singh, Mercedes C. Pride, Wake G. Monroe, George R. Taylor, Alysha N. Hunter, Gregg Roman, Jason J. Paris, Eden E. L. Tanner
Publikováno v:
Advanced Science, Vol 11, Iss 23, Pp n/a-n/a (2024)
Abstract Delivering cargo to the central nervous system (CNS) remains a pharmacological challenge. For infectious diseases such as HIV, the CNS acts as a latent reservoir that is inadequately managed by systemic antiretrovirals (ARTs). ARTs thus cann
Externí odkaz:
https://doaj.org/article/77ac1558810a4cc5a458b91640608794
Autor:
Madison L. Doolittle, Dominik Saul, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Kevin D. Pavelko, Joshua N. Farr, David G. Monroe, Sundeep Khosla
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Senescence drives organismal aging, yet the deep characterization of senescent cells in vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully validated antibodies to analyze senescent cells at single-cell r
Externí odkaz:
https://doaj.org/article/9fa996d1eacd483380e6493e7833f68e
Autor:
Madison L. Doolittle, Brittany A. Eckhardt, Stephanie J. Vos, Sarah Grain, Jennifer L. Rowsey, Ming Ruan, Dominik Saul, Joshua N. Farr, Megan M. Weivoda, Sundeep Khosla, David G. Monroe
Publikováno v:
JBMR Plus, Vol 7, Iss 10, Pp n/a-n/a (2023)
ABSTRACT Estrogen regulates bone mass in women and men, but the underlying cellular mechanisms of estrogen action on bone remain unclear. Although both estrogen receptor (ER)α and ERβ are expressed in bone cells, ERα is the dominant receptor for s
Externí odkaz:
https://doaj.org/article/fce9a970aa3344afb432ff2b7082076c
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Autor:
Dominik Saul, Robyn Laura Kosinsky, Elizabeth J. Atkinson, Madison L. Doolittle, Xu Zhang, Nathan K. LeBrasseur, Robert J. Pignolo, Paul D. Robbins, Laura J. Niedernhofer, Yuji Ikeno, Diana Jurk, João F. Passos, LaTonya J. Hickson, Ailing Xue, David G. Monroe, Tamara Tchkonia, James L. Kirkland, Joshua N. Farr, Sundeep Khosla
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Identification of senescent cells in vivo remains a challenging task. Here the authors present and validate a senescence gene set called SenMayo enriched in human and murine aged tissues.
Externí odkaz:
https://doaj.org/article/e07e402c5be742719a9abae3ab241ab2
Autor:
Japneet Kaur, Dominik Saul, Madison L. Doolittle, Joshua N. Farr, Sundeep Khosla, David G. Monroe
Publikováno v:
JBMR Plus, Vol 7, Iss 6, Pp n/a-n/a (2023)
ABSTRACT Aging is a major risk factor for most chronic diseases, including osteoporosis, and is characterized by an accumulation of senescent cells in various tissues. MicroRNAs (miRNAs) are critical regulators of bone aging and cellular senescence.
Externí odkaz:
https://doaj.org/article/26d0a15186a145048a5618b84caabc90
Autor:
Joshua N. Farr, Dominik Saul, Madison L. Doolittle, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Mitchell N. Froemming, Anthony B. Lagnado, Yi Zhu, Megan Weivoda, Yuji Ikeno, Robert J. Pignolo, Laura J. Niedernhofer, Paul D. Robbins, Diana Jurk, João F. Passos, Nathan K. LeBrasseur, Tamara Tchkonia, James L. Kirkland, David G. Monroe, Sundeep Khosla
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including bone loss. However, the local versus systemic roles of SnCs in mediating tissue dysfunction remain unclear. Thus, we developed a mouse model (p16-LOX-ATTAC) th
Externí odkaz:
https://doaj.org/article/fc80a778d0594c49a7d28805675dc1fe
Autor:
Subhabrata Biswas, Aditi Chalishazar, Ynes Helou, Joanna DiSpirito, Brian DeChristopher, Devin Chatterjee, Leidy Merselis, Benjamin Vincent, John G. Monroe, Dania Rabah, Andrew J. Long
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
MALT1 forms part of a central signaling node downstream of immunoreceptor tyrosine-based activation motif (ITAM)-containing receptors, across a broad range of immune cell subsets, and regulates NF-κB driven transcriptional responses via dual scaffol
Externí odkaz:
https://doaj.org/article/42df9f216d2547f9a8f3e355f8387413
Autor:
Swaathi Jayaraman, Xiaonan Hou, Mary J. Kuffel, Vera J. Suman, Tanya L. Hoskin, Kathryn E. Reinicke, David G. Monroe, Krishna R. Kalari, Xiaojia Tang, Megan A. Zeldenrust, Jingfei Cheng, Elizabeth S. Bruinsma, Sarah A. Buhrow, Renee M. McGovern, Stephanie L. Safgren, Chad A. Walden, Jodi M. Carter, Joel M. Reid, James N. Ingle, Matthew M. Ames, John R. Hawse, Matthew P. Goetz
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-12 (2020)
Abstract Background The tamoxifen metabolite, Z-endoxifen, demonstrated promising antitumor activity in endocrine-resistant estrogen receptor-positive (ER+) breast cancer. We compared the antitumor activity of Z-endoxifen with tamoxifen and letrozole
Externí odkaz:
https://doaj.org/article/1f0ba8cf46c9435685e14beccf269d8f
Autor:
Megan M. Weivoda, Chee Kian Chew, David G. Monroe, Joshua N. Farr, Elizabeth J. Atkinson, Jennifer R. Geske, Brittany Eckhardt, Brianne Thicke, Ming Ruan, Amanda J. Tweed, Louise K. McCready, Robert A. Rizza, Aleksey Matveyenko, Moustapha Kassem, Thomas Levin Andersen, Adrian Vella, Matthew T. Drake, Bart L. Clarke, Merry Jo Oursler, Sundeep Khosla
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Anti-resorptive bone therapies also inhibit bone formation, as osteoclasts secrete factors that stimulate bone formation by osteoblasts. Here, the authors identify osteoclast-secreted factors that couple bone resorption to bone formation in healthy s
Externí odkaz:
https://doaj.org/article/801d47b97fd94e109d4d6b51b08d8de3
Autor:
C. R. Lawrence, J. Beem-Miller, A. M. Hoyt, G. Monroe, C. A. Sierra, S. Stoner, K. Heckman, J. C. Blankinship, S. E. Crow, G. McNicol, S. Trumbore, P. A. Levine, O. Vindušková, K. Todd-Brown, C. Rasmussen, C. E. Hicks Pries, C. Schädel, K. McFarlane, S. Doetterl, C. Hatté, Y. He, C. Treat, J. W. Harden, M. S. Torn, C. Estop-Aragonés, A. Asefaw Berhe, M. Keiluweit, Á. Della Rosa Kuhnen, E. Marin-Spiotta, A. F. Plante, A. Thompson, Z. Shi, J. P. Schimel, L. J. S. Vaughn, S. F. von Fromm, R. Wagai
Publikováno v:
Earth System Science Data, Vol 12, Pp 61-76 (2020)
Radiocarbon is a critical constraint on our estimates of the timescales of soil carbon cycling that can aid in identifying mechanisms of carbon stabilization and destabilization and improve the forecast of soil carbon response to management or enviro
Externí odkaz:
https://doaj.org/article/89d3a5114a20426498ca912c1c0c433b