Zobrazeno 1 - 10
of 256
pro vyhledávání: '"A G M, Schilder"'
Autor:
Anne G. M. Schilder, Stephan Wolpert, Shakeel Saeed, Leonie M. Middelink, Albert S. B. Edge, Helen Blackshaw, REGAIN Consortium, Kostas Pastiadis, Athanasios G. Bibas
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Inhibition of Notch signalling with a gamma-secretase inhibitor (GSI) induces mammalian hair cell regeneration and partial hearing restoration. In this proof-of-concept Phase I/IIa multiple-ascending dose open-label trial (ISRCTN59733689), a
Externí odkaz:
https://doaj.org/article/c507482871e1458b9e7192e6aabb92b2
Autor:
Avgi Loizidou, Taranjit Singh Tatla, Ian Harvey, Miriayi Aibibula, Justin Roe, Neeraj Sethi, Anne G. M. Schilder
Publikováno v:
BMC Health Services Research, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Flexible nasendoscopy (FNE) is an invaluable multi-disciplinary tool for upper aerodigestive tract (UADT) examination. During the COVID-19 pandemic concerns were raised that FNE had the potential of generating aerosols resulting i
Externí odkaz:
https://doaj.org/article/3a254b19d42f4f0492ad389ceb91b704
Autor:
Paul Little, Alastair D Hay, Lucy Yardley, G Ardine de Wit, Nicolaas P A Zuithoff, Sibyl Anthierens, Roderick P Venekamp, Anne G M Schilder, Roger A M J Damoiseaux, Elisabeth A M Sanders, Saskia Hullegie, Joline L H de Sévaux
Publikováno v:
BMJ Open, Vol 13, Iss 2 (2023)
Introduction Ear pain is the most prominent symptom of childhood acute otitis media (AOM). To control the pain and reduce reliance on antibiotics, evidence of effectiveness for alternative interventions is urgently needed. This trial aims to investig
Externí odkaz:
https://doaj.org/article/c4f15a0209f245c88647c4e00575252f
Autor:
Rick T. van Uum, Roderick P. Venekamp, Clémence T. B. Pasmans, G. Ardine de Wit, Alies Sjoukes, Alma C. van der Pol, Roger A. M. J. Damoiseaux, Anne G. M. Schilder
Publikováno v:
BMC Health Services Research, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Background Acute otitis media (AOM) is among the most common paediatric conditions managed in primary care. Most recent estimates of the cost of AOM date from a decade ago and lack a full societal perspective. We therefore explored the socie
Externí odkaz:
https://doaj.org/article/98a2c72ae3124236b10ebbfa87e9ed4a
Autor:
Evie C. Landry, Mirre Scholte, Matthew P. Su, Yvette Horstink, Rishi Mandavia, Maroeska M. Rovers, Anne G. M. Schilder
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
BackgroundHealth systems face challenges to accelerate access to innovations that add value and avoid those unlikely to do so. This is very timely to the field of age-related sensorineural hearing loss (ARHL), where a significant unmet market need ha
Externí odkaz:
https://doaj.org/article/857753b07afc40039c02316eb20670f4
Autor:
Stephen Morris, Mike Thomas, Claire Hopkins, Helen Blackshaw, Carl M Philpott, Elizabeth Williamson, James R Carpenter, Spiros Denaxas, Anne G M Schilder, Caroline S Clarke
Publikováno v:
BMJ Open, Vol 12, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/6f2509fee948408e86fca477748442d0
Autor:
Saskia Hullegie, Anne G. M. Schilder, Paola Marchisio, Joline L. H. de Sévaux, Alike W. van der Velden, Alma C. van de Pol, Josi A. Boeijen, Tamara N. Platteel, Sara Torretta, Roger A. M. J. Damoiseaux, Roderick P. Venekamp
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
IntroductionRecent reports have highlighted the impact of the COVID-19 pandemic on the incidence of infectious disease illnesses and antibiotic use. This study investigates the effect of the pandemic on childhood incidence of otitis media (OM) and as
Externí odkaz:
https://doaj.org/article/2b9115d4378b42a686ecec9c637a1bff
Autor:
Rick T. van Uum, Roderick P. Venekamp, Anne G. M. Schilder, Roger A. M. J. Damoiseaux, Sibyl Anthierens
Publikováno v:
BMC Family Practice, Vol 20, Iss 1, Pp 1-7 (2019)
Abstract Background For unclarified reasons, parents tend to be cautious about administering analgesics to their children, potentially leading to suboptimal management of AOM symptoms. We aim to understand parents’ views and expectations of pain ma
Externí odkaz:
https://doaj.org/article/6971099ea4334e11abde11e37417f1a8
Autor:
Rick T. van Uum, Roderick P. Venekamp, Alies Sjoukes, Alma C. van de Pol, G. Ardine de Wit, Anne G. M. Schilder, Roger A. M. J. Damoiseaux
Publikováno v:
Trials, Vol 19, Iss 1, Pp 1-9 (2018)
Abstract Background Whilst current guidelines highlight the importance of pain management for children with acute otitis media (AOM), there is evidence to suggest that this is not implemented in everyday practice. We have developed a primary care-bas
Externí odkaz:
https://doaj.org/article/84d8997b08be4da5a1ea0e22884aab28
Autor:
Caroline R. Anderson, Carol Xie, Matthew P. Su, Maria Garcia, Helen Blackshaw, Anne G. M. Schilder
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Background: Advances in the understanding of the genetic and molecular etiologies of inner ear disorders have enabled the identification of therapeutic targets and innovative delivery approaches to the inner ear. As this field grows, the need for kno
Externí odkaz:
https://doaj.org/article/a410c37e8576479086ede16516add82b