Zobrazeno 1 - 10
of 277
pro vyhledávání: '"A G, Wee"'
Autor:
Iván del Moral-Sánchez, Edmund G. Wee, Yuejiao Xian, Wen-Hsin Lee, Joel D. Allen, Alba Torrents de la Peña, Rebeca Fróes Rocha, James Ferguson, André N. León, Sylvie Koekkoek, Edith E. Schermer, Judith A. Burger, Sanjeev Kumar, Robby Zwolsman, Mitch Brinkkemper, Aafke Aartse, Dirk Eggink, Julianna Han, Meng Yuan, Max Crispin, Gabriel Ozorowski, Andrew B. Ward, Ian A. Wilson, Tomáš Hanke, Kwinten Sliepen, Rogier W. Sanders
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-18 (2024)
Abstract Recombinant native-like HIV-1 envelope glycoprotein (Env) trimers are used in candidate vaccines aimed at inducing broadly neutralizing antibodies. While state-of-the-art SOSIP or single-chain Env designs can be expressed as native-like trim
Externí odkaz:
https://doaj.org/article/9406da7e97304295838f177acd6e13b0
Autor:
Silvia Capucci, Edmund G Wee, Torben Schiffner, Celia C LaBranche, Nicola Borthwick, Albert Cupo, Jonathan Dodd, Hansi Dean, Quentin Sattentau, David Montefiori, Per J Klasse, Rogier W Sanders, John P Moore, Tomáš Hanke
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0293148 (2023)
[This corrects the article DOI: 10.1371/journal.pone.0181886.].
Externí odkaz:
https://doaj.org/article/9afb22a50abb493ea347796b71174785
Publikováno v:
Prosthesis, Vol 3, Iss 4, Pp 331-341 (2021)
The objective was to compare the repeatability between dental faculty, whose clinical practice was primarily restorative dentistry, and final year dental students in categorizing the inherent translucency of images selected at random using either a 3
Externí odkaz:
https://doaj.org/article/64ecef51de5642389dbf1cdd8f91f3f7
Publikováno v:
Vaccines, Vol 11, Iss 7, p 1187 (2023)
We develop candidate HIV-1 vaccines, of which two components, ChAdOx1.tHIVconsv1 (C1) and ChAdOx1.HIVconsv62 (C62), are delivered by the simian adenovirus-derived vaccine vector ChAdOx1. Aberrant adenovirus RNA splicing involving transgene(s) coding
Externí odkaz:
https://doaj.org/article/d2c0d79c90a24a658608c65b279afae5
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 741-753 (2021)
To stop the HIV-1 pandemic, vaccines must induce responses capable of controlling vast HIV-1 variants circulating in the population as well as those evolved in each individual following transmission. Numerous strategies have been proposed, of which t
Externí odkaz:
https://doaj.org/article/85767a31cc0a43679aa7539b0e2ed809
Autor:
Edmund G. Wee, Nathifa A. Moyo, Kevin O. Saunders, Celia LaBranche, Filippo Donati, Silvia Capucci, Robert Parks, Nicola Borthwick, Zara Hannoun, David C. Montefiori, Barton F. Haynes, Tomáš Hanke
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 490- (2022)
Externí odkaz:
https://doaj.org/article/726b4ac73ba5410185fee5e98d031359
Publikováno v:
Prosthesis, Vol 2, Iss 4, Pp 266-276 (2020)
The objective of this study was to assess if the setting expansion, compressive strength, compressive modulus and Knoop hardness is reduced in Type III, IV and V gypsum products when excess water is added to recommended water/powder (W/P) ratios for
Externí odkaz:
https://doaj.org/article/9881467ec28c4a9c9c8fbe050a88de3a
Autor:
Beatriz Mothe, Christian Manzardo, Alvaro Sanchez-Bernabeu, Pep Coll, Sara Morón-López, Maria C. Puertas, Miriam Rosas-Umbert, Patricia Cobarsi, Roser Escrig, Núria Perez-Alvarez, Irene Ruiz, Cristina Rovira, Michael Meulbroek, Alison Crook, Nicola Borthwick, Edmund G. Wee, Hongbing Yang, Jose M. Miró, Lucy Dorrell, Bonaventura Clotet, Javier Martinez-Picado, Christian Brander, Tomáš Hanke
Publikováno v:
EClinicalMedicine, Vol 11, Iss , Pp 65-80 (2019)
Background: Strong and broad antiviral T-cell responses targeting vulnerable sites of HIV-1 will likely be a critical component for any effective cure strategy. Methods: BCN01 trial was a phase I, open-label, non-randomized, multicenter study in HIV-
Externí odkaz:
https://doaj.org/article/9525071b69b242ee8ae52281b8baa3b5
Autor:
Nathifa Moyo, Annette B. Vogel, Søren Buus, Stephanie Erbar, Edmund G. Wee, Ugur Sahin, Tomáš Hanke
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 12, Iss , Pp 32-46 (2019)
Focusing T cell responses on the most vulnerable parts of HIV-1, the functionally conserved regions of HIV-1 proteins, is likely a key prerequisite for vaccine success. For a T cell vaccine to efficiently control HIV-1 replication, the vaccine-elicit
Externí odkaz:
https://doaj.org/article/4001d86cb5264b179c093c665745d71f
Publikováno v:
Vaccines, Vol 10, Iss 6, p 960 (2022)
In this study, we invented and construct novel candidate HIV-1 vaccines. Through genetic and protein engineering, we unknowingly constructed an HIV-1-derived transgene with a homopolymeric run of 11 cytidines, which was inserted into an adenovirus va
Externí odkaz:
https://doaj.org/article/895deba437e546f5b8ca79abe46bea1b