Výsledky vyhledávání - "A G, Ven'iaminova"

[Cholesterol-modified anti-MDR1 small interfering RNA: uptake and biological activity]

Autor: I S, Kruglova, M I, Meshchaninova, A G, Ven'iaminova, M A, Zenkova, V V, Vlasov, E L, Chernolovskaia

Publikováno v: Molekuliarnaia biologiia. 44(2)

Small interfering RNAs (siRNA) are considered to be potent agents for specific gene silencing, but troubles in delivery of siRNA into cells limit their biomedical application. An accumulation of siRNA coupled with cholesterol residue at the 5'-end of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9e8b4c6744557ca1aa3245d7dd59eef
https://pubmed.ncbi.nlm.nih.gov/20586189

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[C-terminal fragment of ribosomal protein S15 is located at the decoding site of the human ribosome]

Autor: Iu S, Khaĭrulina, M V, Molotkov, K N, Bulygin, D M, Graĭfer, A G, Ven'iaminova, G G, Karpova

Publikováno v: Molekuliarnaia biologiia. 42(2)

Protein S15 is a characteristic component of the mammalian 80S ribosome that neighbors mRNA codon at the decoding site and the downstream triplets. In this study we determined S15 protein fragments located close to mRNA positions +4 to +12 with respe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::487cb8262b0df93ffbb1ba4bcbf602a1
https://pubmed.ncbi.nlm.nih.gov/18610839

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[C-domain of translation termination factor eRF1 neighbors stop codon at the 80S ribosomal A site]

Autor: K N, Bulygin, E A, Popugaeva, M N, Repkova, M I, Meshchaninova, A G, Ven'iaminova, D M, Gaĭfer, L Iu, Frolova, G G, Karpova

Publikováno v: Molekuliarnaia biologiia. 41(5)

Positioning of stop codon and the adjacent triplet downstream of it with respect to the components of human 80S termination complex was studied with the use of mRNA analogues that bore stop signal UPuPuPu (Pu is A or G) and photoactivatable perfluoro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::de3b44eb63c78f7199d2cbb5b363a738
https://pubmed.ncbi.nlm.nih.gov/18240568

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[Protein S3 in the human 80S ribosome adjoins mRNA from 3'-side of the A-site codon]

Autor: M V, Molotkov, D M, Graĭfer, E A, Popugaeva, K N, Bulygin, M I, Meshchaninova, A G, Ven'iaminova, G G, Karpova

Publikováno v: Bioorganicheskaia khimiia. 33(4)

The protein environment of mRNA 3' of the A-site codon (the decoding site) in the human 80S ribosome was studied using a set of oligoribonucleotide derivatives bearing a UUU triplet at the 5'-end and a perfluoroarylazide group at one of the nucleotid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4792096e9497386b7b5121f4805fd741
https://pubmed.ncbi.nlm.nih.gov/17886434

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[Silencing of c-myc gene expression by enzymatically and chemically synthesized siRNAs]

Autor: T O, Kabilova, A V, Vladimirova, M N, Repkova, A G, Ven'iaminova, E L, Chernolovskaia, V V, Vlasov

Publikováno v: Molekuliarnaia biologiia. 40(6)

Small interfering RNAs (siRNA) provide a powerful approach for sequence-specific silencing of gene expression. In the present study we investigated inhibition of c-myc gene expression by siRNAs targeted to the sequence 1452-1470 b. in third exon of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::baf891798839c86b595203638893570a
https://pubmed.ncbi.nlm.nih.gov/17209432

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[Positioning of mRNA 3' of the a site bound codon on the human 80S ribosome]

Autor: M V, Molotkov, D M, Graĭfer, N A, Demeshkina, M N, Repkova, A G, Ven'iaminova, G G, Karpova

Publikováno v: Molekuliarnaia biologiia. 39(6)

Short mRNA analogues carrying a UUU triplet at the 5'-termini and a perfluorophenylazide group at either the N7 atom of the guanosine or the C5 atom of the uridine 3' of the triplet were applied to study positioning of mRNA 3' of the A site codon. Co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::536d4de65b7ec8cd6a54ab81fb1ae269
https://pubmed.ncbi.nlm.nih.gov/16358737

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[Part of the matrix on the 5' side from codon in the E-segment is close to protein S26 on the human 80S ribosome]

Autor: M V, Molotkov, D M, Graĭfer, A V, Eremina, A V, Ivanov, E S, Laletina, M N, Repkova, A G, Ven'iaminova, G G, Karpova

Publikováno v: Molekuliarnaia biologiia. 38(6)

Positioning of mRNA on the 80S ribosome upstream the E site bound codon was studied using derivatives of nona- and dodecaribonucleotides containing the triplet UUU coding for Phe at the 3'-terminus, and a perfluorophenylazide cross-linker on either t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb1565170603fa374b712247abe2bb1f
https://pubmed.ncbi.nlm.nih.gov/15612591

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[Protein environment of the sense codon of the template in the A site of the human ribosome as inferred from crosslinking to oligoribonucleotide derivatives]

Autor: M V, Molotkov, D M, Graĭfer, M I, Meshchaninova, M N, Repkova, A G, Ven'iaminova, G G, Karpova

Publikováno v: Molekuliarnaia biologiia. 38(3)

The protein environment of each nucleotide of the template codon located in the A site of the human ribosome was studied with UUCUCAA and UUUGUU derivatives containing a Phe codon (UUC and UUU, respectively) and a perfluoroarylazido group at U4, U5,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::65c85c63456252d47ff627e2fd92f6ef
https://pubmed.ncbi.nlm.nih.gov/15285619

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[The first nucleotide of the codon located in the P site of the 80S ribosome is close to G1702 of the 18S rRNA as revealed by crosslinking to a pUUUGUU derivative containing a perfluorophenylazido group at the guanine]

Autor: N A, Demeshkina, M N, Repkova, A G, Ven'iaminova, D M, Graĭfer, G G, Karpova

Publikováno v: Molekuliarnaia biologiia. 38(3)

Modification of the 18S rRNA with a pUUUGUU derivative carrying a perfluorophenylazido group at N7 of G was studied in the complex with the human 80S ribosome and Val-tRNA(Val), which directs modified GUU to the P site. Reverse transcription reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e378623be4ae5e88c9c3b30c9d367eac
https://pubmed.ncbi.nlm.nih.gov/15285620

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