Zobrazeno 1 - 10
of 59
pro vyhledávání: '"A G, Therien"'
Autor:
Stephen H. Kasper, Stephanie Otten, Brian Squadroni, Cionna Orr‐Terry, Yi Kuang, Lily Mussallem, Lan Ge, Lin Yan, Srinivasaraghavan Kannan, Chandra S. Verma, Christopher J. Brown, Charles W. Johannes, David P. Lane, Arun Chandramohan, Anthony W. Partridge, Lee R. Roberts, Hubert Josien, Alex G. Therien, Erik C. Hett, Bonnie J. Howell, Andrea Peier, Xi Ai, Jason Cassaday
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 5, Pp n/a-n/a (2023)
Abstract Cyclic peptides are poised to target historically difficult to drug intracellular protein–protein interactions, however, their general cell impermeability poses a challenge for characterizing function. Recent advances in microfluidics have
Externí odkaz:
https://doaj.org/article/4ede5586001347c2a4d447e4b2a014ec
Autor:
Upasana Parthasarathy, Yi Kuang, Gunjan Thakur, John D. Hogan, Thomas P. Wyche, James E. Norton, Jr., Jason R. Killough, Theodore R. Sana, Caroline Beakes, BaoJen Shyong, Rena N. Zhang, Dario A. Gutierrez, Michael Filbin, David C. Christiani, Alex G. Therien, Christopher H. Woelk, Cory H. White, Roberta Martinelli
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105948- (2023)
Summary: Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Despite continued efforts to understand the pathophysiology of sepsis, no effective therapies are currently available. While singular components of t
Externí odkaz:
https://doaj.org/article/a7bebae0729f4859866504aea19e208c
Autor:
Abigail L. Reens, Damien J. Cabral, Xue Liang, James E. Norton, Alex G. Therien, Daria J. Hazuda, Gokul Swaminathan
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Emerging evidence in clinical and preclinical studies indicates that success of immunotherapies can be impacted by the state of the microbiome. Understanding the role of the microbiome during immune-targeted interventions could help us understand het
Externí odkaz:
https://doaj.org/article/f6b60dccb4494d5f9ae6e9a732fc83c4
Autor:
Nicholas Murgolo, Alex G Therien, Bonnie Howell, Daniel Klein, Kenneth Koeplinger, Linda A Lieberman, Gregory C Adam, Jessica Flynn, Philip McKenna, Gokul Swaminathan, Daria J Hazuda, David B Olsen
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009225 (2021)
Since the initial report of the novel Coronavirus Disease 2019 (COVID-19) emanating from Wuhan, China, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally. While the effects of SARS-CoV-2 infection are not completely unde
Externí odkaz:
https://doaj.org/article/6909c68dee10406c8b165a62d0e69a18
Autor:
Mihirbaran Mandal, Li Xiao, Weidong Pan, Giovanna Scapin, Guoqing Li, Haiqun Tang, Shu-Wei Yang, Jianping Pan, Yuriko Root, Reynalda Keh de Jesus, Christine Yang, Winnie Prosise, Priya Dayananth, Asra Mirza, Alex G. Therien, Katherine Young, Amy Flattery, Charles Garlisi, Rumin Zhang, Donald Chu, Payal Sheth, Inhou Chu, Jin Wu, Carrie Markgraf, Hai-Young Kim, Ronald Painter, Todd W. Mayhood, Edward DiNunzio, Daniel F. Wyss, Alexei V. Buevich, Thierry Fischmann, Alexander Pasternak, Shuzhi Dong, Jacqueline D. Hicks, Artjohn Villafania, Lianzhu Liang, Nicholas Murgolo, Todd Black, William K. Hagmann, Jim Tata, Emma R. Parmee, Ann E. Weber, Jing Su, Haifeng Tang
Publikováno v:
Journal of Medicinal Chemistry. 65:16234-16251
With the emergence and rapid spreading of NDM-1 and existence of clinically relevant VIM-1 and IMP-1, discovery of pan inhibitors targeting metallo-beta-lactamases (MBLs) became critical in our battle against bacterial infection. Concurrent with our
Autor:
null Stephen H. Kasper, null Stephanie Otten, null Brian Squadroni, null Cionna Orr‐Terry, null Yi Kuang, null Lily Mussallem, null Lan Ge, null Lin Yan, null Srinivasaraghavan Kannan, null Chandra S. Verma, null Christopher J. Brown, null Charles W. Johannes, null David P. Lane, null Arun Chandramohan, null Anthony W. Partridge, null Lee R. Roberts, null Hubert Josien, null Alex G. Therien, null Erik C. Hett, null Bonnie J. Howell, null Andrea Peier, null Xi Ai, null Jason Cassaday
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90a3660365f9c9945a524ebfb3f98bc0
https://doi.org/10.1002/btm2.10542/v2/response1
https://doi.org/10.1002/btm2.10542/v2/response1
Autor:
U. Parthasarathy, Y. Kuang, G. Thakur, J.D. Hogan, T.P. Wyche, J.E. Norton, J.R. Killough, T.R. Sana, C. Beakes, B. Shyong, N.R. Zhang, D.A. Gutierrez, M. Filbin, D.C. Christiani, A. G. Therien, C.H. Woelk, C.H. White, R. Martinelli
Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Despite continued efforts to understand the pathophysiology of sepsis, no effective therapies are currently available. While singular components of the aberra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceb1055f439f67414ffa3edd4a6632e9
https://doi.org/10.1101/2022.02.01.478658
https://doi.org/10.1101/2022.02.01.478658
Publikováno v:
Biochemical Pharmacology
Graphical abstract
The host response to SARS-CoV-2, the virus that causes COVID-19, is highly heterogeneous, ranging from mild/asymptomatic to severe. The moderate to severe forms of COVID-19 often require hospitalization, are associated with a
The host response to SARS-CoV-2, the virus that causes COVID-19, is highly heterogeneous, ranging from mild/asymptomatic to severe. The moderate to severe forms of COVID-19 often require hospitalization, are associated with a
Autor:
Kavitha Bekkari, Pulkit Gupta, Nicholas Murgolo, Heather K. Kroh, Swetha Raman, Zhifen Zhang, Lorraine D. Hernandez, Roman A. Melnyk, Jean-Phillipe Julien, John Kit Chung Tam, D. Borden Lacy, Alex G. Therien, Seiji Sugiman-Marangos
Publikováno v:
Journal of Biological Chemistry. 292:17290-17301
Clostridium difficile is a major nosocomial pathogen that produces two exotoxins, TcdA and TcdB, with TcdB thought to be the primary determinant in human disease. TcdA and TcdB are large, multidomain proteins, each harboring a cytotoxic glucosyltrans
Autor:
Linda A. Lieberman, Nicholas Murgolo, Alex G. Therien, Gokul Swaminathan, Philip M. McKenna, Daniel J. Klein, Daria J. Hazuda, Bonnie J. Howell, David B. Olsen, Kenneth A. Koeplinger, Gregory C. Adam, Jessica A. Flynn
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009225 (2021)
PLoS Pathogens
PLoS Pathogens
Since the initial report of the novel Coronavirus Disease 2019 (COVID-19) emanating from Wuhan, China, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally. While the effects of SARS-CoV-2 infection are not completely unde