Variable bioenergetic sensitivity of neurons and astrocytes to insulin and extracellular glucose

Autor: Sophiya L. Sims, Hilaree N. Frazier, Sami L. Case, Ruei-Lung Lin, James N. Trosper, Hemendra J. Vekaria, Patrick G. Sullivan, Olivier Thibault

Publikováno v: npj Metabolic Health and Disease, Vol 2, Iss 1, Pp 1-13 (2024)

Abstract Energy flow within cellular elements of the brain is a well-orchestrated, tightly regulated process, however, details underlying these functions at the single-cell level are still poorly understood. Studying hypometabolism in aging and neuro

Externí odkaz: https://doaj.org/article/59b63f3586d34508b0cc9f1d68c03cf7

Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States

Autor: Amanda C Perofsky, John Huddleston, Chelsea L Hansen, John R Barnes, Thomas Rowe, Xiyan Xu, Rebecca Kondor, David E Wentworth, Nicola Lewis, Lynne Whittaker, Burcu Ermetal, Ruth Harvey, Monica Galiano, Rodney Stuart Daniels, John W McCauley, Seiichiro Fujisaki, Kazuya Nakamura, Noriko Kishida, Shinji Watanabe, Hideki Hasegawa, Sheena G Sullivan, Ian G Barr, Kanta Subbarao, Florian Krammer, Trevor Bedford, Cécile Viboud

Publikováno v: eLife, Vol 13 (2024)

Influenza viruses continually evolve new antigenic variants, through mutations in epitopes of their major surface proteins, hemagglutinin (HA) and neuraminidase (NA). Antigenic drift potentiates the reinfection of previously infected individuals, but

Externí odkaz: https://doaj.org/article/d48411453a434048a41f9bcc8eba52b3

An efficient and high-throughput method for the evaluation of mitochondrial dysfunction in frozen brain samples after traumatic brain injury

Autor: Hemendra J. Vekaria, Olivia J. Kalimon, Paresh Prajapati, Gopal V. Velmurugan, Patrick G. Sullivan

Publikováno v: Frontiers in Molecular Biosciences, Vol 11 (2024)

Mitochondrial function analysis is a well-established method used in preclinical and clinical investigations to assess pathophysiological changes in various disease states, including traumatic brain injury (TBI). Although there are multiple approache

Externí odkaz: https://doaj.org/article/37f7e14b817c4d12a5b5b40145968e8b

In situ estimation of ice crystal properties at the South Pole using LED calibration data from the IceCube Neutrino Observatory

Autor: R. Abbasi, M. Ackermann, J. Adams, N. Aggarwal, J. Aguilar, M. Ahlers, M. Ahrens, J.-M. Alameddine, A. A. Alves Junior, N. M. B. Amin, K. Andeen, T. Anderson, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, S. Axani, X. Bai, A. Balagopal V, M. Baricevic, S. Barwick, V. Basu, R. Bay, J. Beatty, K. H. Becker, J. Becker Tjus, J. Beise, C. Bellenghi, S. Benda, S. BenZvi, D. Berley, E. Bernardini, D. Besson, G. Binder, D. Bindig, E. Blaufuss, S. Blot, F. Bontempo, J. Book, J. Borowka, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, E. Bourbeau, J. Braun, B. Brinson, J. Brostean-Kaiser, R. Burley, R. Busse, M. Campana, E. Carnie-Bronca, C. Chen, Z. Chen, D. Chirkin, K. Choi, B. Clark, L. Classen, A. Coleman, G. Collin, A. Connolly, J. Conrad, P. Coppin, P. Correa, S. Countryman, D. Cowen, R. Cross, C. Dappen, P. Dave, C. De Clercq, J. DeLaunay, D. Delgado López, H. Dembinski, K. Deoskar, A. Desai, P. Desiati, K. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, H. Dujmovic, M. DuVernois, T. Ehrhardt, P. Eller, R. Engel, H. Erpenbeck, J. Evans, P. Evenson, K. L. Fan, A. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, A. Fienberg, C. Finley, L. Fischer, D. Fox, A. Franckowiak, E. Friedman, A. Fritz, P. Fürst, T. Gaisser, J. Gallagher, E. Ganster, A. Garcia, S. Garrappa, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glüsenkamp, T. Glauch, N. Goehlke, J. Gonzalez, S. Goswami, D. Grant, S. Gray, T. Grégoire, S. Griswold, C. Günther, P. Gutjahr, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, K. Hanson, J. Hardin, A. Harnisch, P. Hatch, A. Haungs, K. Helbing, J. Hellrung, F. Henningsen, L. Heuermann, S. Hickford, C. Hill, G. Hill, K. Hoffman, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, N. Iovine, A. Ishihara, M. Jansson, G. Japaridze, M. Jeong, M. Jin, B. Jones, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, U. Katz, M. Kauer, J. Kelley, A. Kheirandish, K. Kin, J. Kiryluk, S. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, E. Krupczak, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Larson, F. Lauber, J. Lazar, J. Lee, K. Leonard, A. Leszczyńska, M. Lincetto, Q. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, A. Ludwig, W. Luszczak, Y. Lyu, W. Y. Ma, J. Madsen, K. Mahn, Y. Makino, S. Mancina, W. Marie Sainte, I. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, S. Meighen-Berger, Y. Merckx, J. Micallef, D. Mockler, T. Montaruli, R. Moore, B. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, U. Naumann, A. Nayerhoda, J. Necker, M. Neumann, H. Niederhausen, M. Nisa, S. Nowicki, A. Obertacke Pollmann, M. Oehler, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O'Sullivan, H. Pandya, D. Pankova, N. Park, G. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, L. Peters, J. Peterson, S. Philippen, S. Pieper, A. Pizzuto, M. Plum, Y. Popovych, A. Porcelli, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. Przybylski, C. Raab, J. Rack-Helleis, M. Rameez, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, G. Renzi, E. Resconi, S. Reusch, W. Rhode, M. Richman, B. Riedel, E. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, D. Rysewyk Cantu, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, M. Schaufel, H. Schieler, S. Schindler, B. Schlüter, T. Schmidt, J. Schneider, F. Schröder, L. Schumacher, G. Schwefer, S. Sclafani, D. Seckel, S. Seunarine, A. Sharma, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, C. Spannfellner, G. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, R. Stein, T. Stezelberger, T. Stürwald, T. Stuttard, G. Sullivan, I. Taboada, S. Ter-Antonyan, W. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, B. Ty, M. Unland Elorrieta, K. Upshaw, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, S. Verpoest, D. Veske, C. Walck, W. Wang, T. B. Watson, C. Weaver, P. Weigel, A. Weindl, J. Weldert, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. Wiebusch, N. Willey, D. Williams, M. Wolf, G. Wrede, J. Wulff, X. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, S. Yu, T. Yuan, Z. Zhang, P. Zhelnin

Publikováno v: The Cryosphere, Vol 18, Pp 75-102 (2024)

The IceCube Neutrino Observatory instruments about 1 km3 of deep, glacial ice at the geographic South Pole. It uses 5160 photomultipliers to detect Cherenkov light emitted by charged relativistic particles. An unexpected light propagation effect obse

Externí odkaz: https://doaj.org/article/26f630cffc47491ebaac7cf7801c70c5

Characterizing Sex Differences in Mitochondrial Dysfunction After Severe Traumatic Brain Injury in Mice

Autor: Olivia J. Kalimon, Hemendra J. Vekaria, Gopal V. Velmurugan, W. Brad Hubbard, Patrick G. Sullivan

Publikováno v: Neurotrauma Reports, Vol 4, Iss 1, Pp 627-642 (2023)

Traumatic brain injury (TBI) is caused by an impact or penetrating injury to the head resulting in abnormal brain function. Mitochondrial dysfunction is an important hallmark of TBI and has been thoroughly studied in male rodent models of brain injur

Externí odkaz: https://doaj.org/article/546dfda817774a33880b1afc465a2a50