Zobrazeno 1 - 10
of 27
pro vyhledávání: '"A G, Schuurman"'
Autor:
Jeroen Melief, Marie Orre, Koen Bossers, Corbert G. van Eden, Karianne G. Schuurman, Matthew R. J. Mason, Joost Verhaagen, Jörg Hamann, Inge Huitinga
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-19 (2019)
Abstract Inter-individual differences in cortisol production by the hypothalamus–pituitary–adrenal (HPA) axis are thought to contribute to clinical and pathological heterogeneity of multiple sclerosis (MS). At the same time, accumulating evidence
Externí odkaz:
https://doaj.org/article/91ae7c2831ea493c9b3564de0c282815
Autor:
Marlijn van der Poel, Thomas Ulas, Mark R. Mizee, Cheng-Chih Hsiao, Suzanne S. M. Miedema, Adelia, Karianne G. Schuurman, Boy Helder, Sander W. Tas, Joachim L. Schultze, Jörg Hamann, Inge Huitinga
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
It is unclear if early pathological changes in normal-appearing multiple sclerosis (MS) tissue are reflected by molecular changes in microglia, which might contribute to lesion initiation. Here, authors demonstrate significant intrinsic differences i
Externí odkaz:
https://doaj.org/article/3dba4ae06f6a4f6d8d2e10b0073b7819
Autor:
Debbie A. E. Hendrickx, Jackelien van Scheppingen, Marlijn van der Poel, Koen Bossers, Karianne G. Schuurman, Corbert G. van Eden, Elly M. Hol, Jörg Hamann, Inge Huitinga
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
In multiple sclerosis (MS), activated microglia and infiltrating macrophages phagocytose myelin focally in (chronic) active lesions. These demyelinating sites expand in time, but at some point turn inactive into a sclerotic scar. To identify molecula
Externí odkaz:
https://doaj.org/article/7f9643f8b245453087905fa7eb1eccd6
Autor:
J. G. Schuurman, J. De Jong
Publikováno v:
MAB, Vol 68, Iss 1/2, Pp 70-73 (1994)
Externí odkaz:
https://doaj.org/article/8509e1f1104d444da747a193849421c4
Autor:
Thomas Ulas, Jörg Hamann, Cheng-Chih Hsiao, Joachim L. Schultze, Mark R. Mizee, Karianne G. Schuurman, Suzanne S. M. Miedema, Boy Helder, Adelia, Inge Huitinga, Sander W. Tas, Marlijn van der Poel
Publikováno v:
Nature Communications
Nature Communications 10(1), 1139 (2019). doi:10.1038/s41467-019-08976-7
Nature Communications, 10:1139. Nature Publishing Group
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature communications, 10(1). Nature Publishing Group
Nature Communications 10(1), 1139 (2019). doi:10.1038/s41467-019-08976-7
Nature Communications, 10:1139. Nature Publishing Group
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature communications, 10(1). Nature Publishing Group
Here we report the transcriptional profile of human microglia, isolated from normal-appearing grey matter (GM) and white matter (WM) of multiple sclerosis (MS) and non-neurological control donors, to find possible early changes related to MS patholog
Autor:
Corbert G. van Eden, Jörg Hamann, Jackelien van Scheppingen, Karianne G. Schuurman, Inge Huitinga, Koen Bossers, Elly M. Hol, Debbie A.E. Hendrickx, Marlijn van der Poel
Publikováno v:
Frontiers in Immunology [E], 8(DEC)
Frontiers in Immunology, 8:1810. Frontiers Media SA
Frontiers in Immunology [E], 8(DEC). Frontiers Media S. A.
Frontiers in immunology, 8. Frontiers Media S.A.
Frontiers in Immunology, Vol 8 (2017)
Frontiers in Immunology
Frontiers in Immunology, 8:1810. Frontiers Media SA
Frontiers in Immunology [E], 8(DEC). Frontiers Media S. A.
Frontiers in immunology, 8. Frontiers Media S.A.
Frontiers in Immunology, Vol 8 (2017)
Frontiers in Immunology
In multiple sclerosis (MS), activated microglia and infiltrating macrophages phagocytose myelin focally in (chronic) active lesions. These demyelinating sites expand in time, but at some point turn inactive into a sclerotic scar. To identify molecula
Autor:
Joost Smolders, Jeroen Melief, Miriam E. van Strien, Mark R. Mizee, Suzanne S. M. Miedema, Debbie A.E. Hendrickx, Adelia, Kirstin M. Heutinck, Karianne G. Schuurman, Marlijn van der Poel, Jörg Hamann, Inge Huitinga
Publikováno v:
Acta Neuropathologica Communications
Mizee, M R, Miedema, S S M, van der Poel, M, Adelia, Schuurman, K G, van Strien, M E, Melief, J, Smolders, J, Hendrickx, D A, Heutinck, K M, Hamann, J & Huitinga, I 2017, ' Isolation of primary microglia from the human post-mortem brain : effects of ante-and post-mortem variables ', Acta Neuropathologica Communications, vol. 5, no. 1, pp. 16 . https://doi.org/10.1186/s40478-017-0418-8
Acta Neuropathologica Communications, 5(1). BioMed Central
Acta neuropathologica communications, 5(1). BioMed Central
Mizee, M R, Miedema, S S M, van der Poel, M, Adelia, Schuurman, K G, van Strien, M E, Melief, J, Smolders, J, Hendrickx, D A, Heutinck, K M, Hamann, J & Huitinga, I 2017, ' Isolation of primary microglia from the human post-mortem brain : effects of ante-and post-mortem variables ', Acta Neuropathologica Communications, vol. 5, no. 1, pp. 16 . https://doi.org/10.1186/s40478-017-0418-8
Acta Neuropathologica Communications, 5(1). BioMed Central
Acta neuropathologica communications, 5(1). BioMed Central
Microglia are key players in the central nervous system in health and disease. Much pioneering research on microglia function has been carried out in vivo with the use of genetic animal models. However, to fully understand the role of microglia in ne
Autor:
Karianne G. Schuurman, Corbert G. van Eden, Inge Huitinga, Jörg Hamann, Debbie A.E. Hendrickx
Publikováno v:
Journal of neuroimmunology, 309, 12-22. Elsevier
Journal of Neuroimmunology, 309, 12-22. Elsevier B.V.
Journal of Neuroimmunology, 309, 12-22. Elsevier B.V.
HLA-DR, Iba1 and CD68 are widely used microglia markers in human tissue. However, due to differences in gene regulation, they may identify different activation stages of microglia. Here, we directly compared the expression of HLA-DR, Iba1 and CD68 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ec0ce1bc8930b48adab9182066a4a4
https://pure.amc.nl/en/publications/staining-of-hladr-iba1-and-cd68-in-human-microglia-reveals-partially-overlapping-expression-depending-on-cellular-morphology-and-pathology(24699071-f3bb-4c39-863e-c76c045ce1fd).html
https://pure.amc.nl/en/publications/staining-of-hladr-iba1-and-cd68-in-human-microglia-reveals-partially-overlapping-expression-depending-on-cellular-morphology-and-pathology(24699071-f3bb-4c39-863e-c76c045ce1fd).html
Autor:
Joost Smolders, Inge Huitinga, Robert M. Hoek, Jeroen Melief, Nathalie Koning, Karianne G. Schuurman, Martijn D. B. van de Garde, Marco van Eijk, Jörg Hamann
Publikováno v:
Melief, J, Koning, N, Schuurman, K G, van de Garde, M D B, Smolders, J, Hoek, R M, van Eijk, M, Hamann, J & Huitinga, I 2012, ' Phenotyping primary human microglia: Tight regulation of LPS responsiveness ', GLIA, vol. 60, no. 10, pp. 1506-1517 . https://doi.org/10.1002/glia.22370
GLIA, 60(10), 1506-1517. John Wiley and Sons Inc.
GLIA, 60, 1506-1517. John Wiley and Sons Inc.
Glia, 60(10), 1506-1517. John Wiley and Sons Inc.
GLIA, 60(10), 1506-1517. John Wiley and Sons Inc.
GLIA, 60, 1506-1517. John Wiley and Sons Inc.
Glia, 60(10), 1506-1517. John Wiley and Sons Inc.
Much is still unknown about mechanisms underlying the phenotypical and functional versatility of human microglia. Therefore, we developed a rapid procedure to isolate pure microglia from postmortem human brain tissue and studied their immediate ex vi
Autor:
Nico P. Dantuma, Fred W. van Leeuwen, Femke M.S. de Vrij, Paula van Tijn, Elly M. Hol, Karianne G. Schuurman, David F. Fischer
Publikováno v:
Journal of Cell Science. 120:1615-1623
The ubiquitin-proteasome system is the main regulated intracellular proteolytic pathway. Increasing evidence implicates impairment of this system in the pathogenesis of diseases with ubiquitin-positive pathology. A mutant ubiquitin, UBB+1, accumulate