Zobrazeno 1 - 10
of 94
pro vyhledávání: '"A G, Schuller"'
Publikováno v:
Acta Orthopaedica, Vol 94 (2023)
Background and purpose: Accurate measuring tools are essential in preoperative planning and for the study of the association between postoperative alignment and clinical outcome in total knee arthroplasty (TKA). We aimed to describe a simple method t
Externí odkaz:
https://doaj.org/article/e05e440ce18049149ec96df28ecebb34
Autor:
Jennifer P Morton, Matthew Wilson, Hannah Buckley, Alwin G Schuller, Richard Goodwin, Kate Williamson, Frances M Richards, Duncan I Jodrell, Saadia A Karim, Simon J Dovedi, Jim Eyles, Vincenzo Graziano, Andreas Dannhorn, Heather Hulme, Sheng Y Lee, Brajesh P Kaistha, Sabita Islam, James E D Thaventhiran, Rebecca Brais
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)
Background The prognosis for patients with pancreatic ductal adenocarcinoma (PDAC) remains extremely poor. It has been suggested that the adenosine pathway contributes to the ability of PDAC to evade the immune system and hence, its resistance to imm
Externí odkaz:
https://doaj.org/article/f9d832bad08344709ee59ce32bb6e960
Autor:
Claire M. Patterson, Srividya B. Balachander, Iain Grant, Petar Pop-Damkov, Brian Kelly, William McCoull, Jeremy Parker, Michael Giannis, Kathryn J. Hill, Francis D. Gibbons, Edward J. Hennessy, Paul Kemmitt, Alexander R. Harmer, Sonya Gales, Stuart Purbrick, Sean Redmond, Matthew Skinner, Lorraine Graham, J. Paul Secrist, Alwin G. Schuller, Shenghua Wen, Ammar Adam, Corinne Reimer, Justin Cidado, Martin Wild, Eric Gangl, Stephen E. Fawell, Jamal Saeh, Barry R. Davies, David J. Owen, Marianne B. Ashford
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Claire Patterson et al. present the design and development of AZD0466, a drug-dendrimer conjugate, and use preclinical and mathematical models to determine the optimal release rate of the drug from the dendrimer carrier for maximal therapeutic index
Externí odkaz:
https://doaj.org/article/722de1f4d6464ec9a94bce51fe4fc356
Autor:
Adriana E. Tron, Matthew A. Belmonte, Ammar Adam, Brian M. Aquila, Lawrence H. Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J. Embrey, Eric Gangl, Francis D. Gibbons, Gareth P. Gregory, David Hargreaves, J. Adam Hendricks, Jeffrey W. Johannes, Ricky W. Johnstone, Steven L. Kazmirski, Jason G. Kettle, Michelle L. Lamb, Shannon M. Matulis, Ajay K. Nooka, Martin J. Packer, Bo Peng, Philip B. Rawlins, Daniel W. Robbins, Alwin G. Schuller, Nancy Su, Wenzhan Yang, Qing Ye, Xiaolan Zheng, J. Paul Secrist, Edwin A. Clark, David M. Wilson, Stephen E. Fawell, Alexander W. Hird
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
High expression of Mcl-1 promotes tumorigenesis and resistance to anticancer therapies. Here they report a macrocyclic molecule with high selectivity and affinity for Mcl-1 that exhibits potent anti-tumor effects as single agent and in combination wi
Externí odkaz:
https://doaj.org/article/814ff3ef6b204d84917e2b025f3e1da9
Autor:
Aatman S. Doshi, Susan Cantin, Marylens Hernandez, Srimathi Srinivasan, Sharon Tentarelli, Matthew Griffin, Yanjun Wang, Petar Pop-Damkov, Laura B. Prickett, Cecilia Kankkonen, Minhui Shen, Maryann San Martin, Song Wu, M. Paola Castaldi, Hormas Ghadially, Jeffrey Varnes, Sonya Gales, David Henry, Clare Hoover, Deanna A. Mele, Iain Simpson, Eric T. Gangl, Scott N. Mlynarski, M. Raymond V. Finlay, Lisa Drew, Stephen E. Fawell, Wenlin Shao, Alwin G. Schuller
Publikováno v:
Molecular Cancer Therapeutics. 22:630-645
Antitumor immunity can be hampered by immunosuppressive mechanisms in the tumor microenvironment, including recruitment of arginase (ARG) expressing myeloid cells that deplete l-arginine essential for optimal T-cell and natural killer cell function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82d755494151ffe43d642a50fe0b9dc5
https://doi.org/10.1158/1535-7163.mct-22-0431
https://doi.org/10.1158/1535-7163.mct-22-0431
Autor:
Rhys D.O. Jones, Klas Petersson, Areya Tabatabai, Larry Bao, Helen Tomkinson, Alwin G. Schuller
Publikováno v:
Molecular Cancer Therapeutics. 22:679-690
Osimertinib is a third-generation, irreversible, oral EGFR tyrosine kinase inhibitor (TKI) recommended as first-line treatment for patients with locally advanced/metastatic EGFR mutation–positive (EGFRm) non–small cell lung cancer (NSCLC). Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfe7da38f494178eb142fb1e59ea55d7
https://doi.org/10.1158/1535-7163.mct-22-0193
https://doi.org/10.1158/1535-7163.mct-22-0193
Autor:
Yanjun Wang, James Brown, Richard Woessner, Alwin G Schuller, Alexandra Borodovsky, Dinesh Chandra, Deanna A Mele, Stephen Fawell, Joseph Shaw, Christine M Barbon, Minwei Ye, Laura Prickett, Nanhua Deng, Kris Sachsenmeier, James D Clarke, Bolan Linghu, Giles A Brown, Miles Congreve, Robert KY Cheng, Andrew S Dore, Edward Hurrell, Wenlin Shao, Corinne Reimer, Lisa Drew
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Methods We report here the development of a small molecule A2AR inhibitor including characterization of binding and inhibition of A2AR function with varying amounts of a stable version of adenosine. Functional activity was tested in both mouse and hu
Externí odkaz:
https://doaj.org/article/84f658f3a812430ca348354c04f4101a
Autor:
Torstein Baade Rø, Rui Yang, Zachary Cooper, Richard Woessner, Samah Elsaadi, Kristine Misund, Pegah Abdollahi, Esten Nymoen Vandsemb, Siv Helen Moen, Anna Kusnierczyk, Geir Slupphaug, Therese Standal, Anders Waage, Tobias S Slørdahl, Even Rustad, Anders Sundan, Carl Hay, Alwin G Schuller, Alexandra Borodovsky, Eline Menu, Magne Børset, Anne Marit Sponaas
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background PD1/PDL1-directed therapies have been unsuccessful for multiple myeloma (MM), an incurable cancer of plasma cells in the bone marrow (BM). Therefore, other immune checkpoints such as extracellular adenosine and its immunosuppressive recept
Externí odkaz:
https://doaj.org/article/0d6878b13bc74341af00666681fe9034
Autor:
Alwin G. Schuller, Helen Tomkinson, Larry Bao, Areya Tabatabai, Klas Petersson, Rhys D.O. Jones
Supplementary Figure S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfb44d09840e0189ff4201d18d6b7c2
https://doi.org/10.1158/1535-7163.22758864
https://doi.org/10.1158/1535-7163.22758864
Autor:
Alwin G. Schuller, Wenlin Shao, Stephen E. Fawell, Lisa Drew, M. Raymond V. Finlay, Scott N. Mlynarski, Eric T. Gangl, Iain Simpson, Deanna A. Mele, Clare Hoover, David Henry, Sonya Gales, Jeffrey Varnes, Hormas Ghadially, M. Paola Castaldi, Song Wu, Maryann San Martin, Minhui Shen, Cecilia Kankkonen, Laura B. Prickett, Petar Pop-Damkov, Yanjun Wang, Matthew Griffin, Sharon Tentarelli, Srimathi Srinivasan, Marylens Hernandez, Susan Cantin, Aatman S. Doshi
Supplementary Figure 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3d060f84133f3a377e582a99492b60
https://doi.org/10.1158/1535-7163.22758750.v1
https://doi.org/10.1158/1535-7163.22758750.v1