Zobrazeno 1 - 10 of 37 pro vyhledávání: '"A G, Sarafanov"'
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Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts
Autor: Haarin Chun, James H. Kurasawa, Philip Olivares, Ekaterina S. Marakasova, Svetlana A. Shestopal, Gabriela U. Hassink, Elena Karnaukhova, Mary Migliorini, Juliet O. Obi, Ally K. Smith, Patrick L. Wintrode, Prasannavenkatesh Durai, Keunwan Park, Daniel Deredge, Dudley K. Strickland, Andrey G. Sarafanov
Publikováno v: Journal of Thrombosis and Haemostasis. 20:2255-2269
Deficiency in blood coagulation factor VIII (FVIII) results in life-threating bleeding (hemophilia A) treated by infusions of FVIII concentrates. To improve disease treatment, FVIII has been modified to increase its plasma half-life, which requires u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe192fa0a6be1b8e8c0b22fd5c2adbb
https://doi.org/10.1111/jth.15817
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3
Plasma Clearance of Coagulation Factor VIII and Extension of Its Half-Life for the Therapy of Hemophilia A: A Critical Review of the Current State of Research and Practice
Autor: Andrey G. Sarafanov
Publikováno v: International Journal of Molecular Sciences. 24:8584
Factor VIII (FVIII) is an important component of blood coagulation as its congenital deficiency results in life-threatening bleeding. Current prophylactic therapy of the disease (hemophilia A) is based on 3–4 intravenous infusions of therapeutic FV
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3a3ce4cba5f0d20d927f41dba1f0147
https://doi.org/10.3390/ijms24108584
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6
Characterization of protein unable to bind von Willebrand factor in recombinant factor VIII products
Autor: Philip Olivares, John R Pettersson, Mikhail V Ovanesov, Stepan S Surov, Ekaterina S. Marakasova, Wells W. Wu, Rong-Fong Shen, Andrey G Sarafanov, Haarin Chun, Svetlana A Shestopal
Publikováno v: Journal of thrombosis and haemostasis : JTHREFERENCES. 19(4)
Background Therapeutic products with coagulation factor VIII (FVIII) have a wide range of specific activities, implying presence of protein with altered structure. Previous studies showed that recombinant FVIII products (rFVIII) contain a fraction (F
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc12dd0a0e89dc1ca4754799fd8d2a2
https://pubmed.ncbi.nlm.nih.gov/33527662
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7
Instability of Plastic Deformation in Metals at Low Temperatures
Autor: Fedor G. Sarafanov, Georgy F. Sarafanov, Igor S. Pavlov
Publikováno v: Multiscale Solid Mechanics ISBN: 9783030549275
Mathematical models of serrated plastic deformation in metals at ultra-low temperatures are developed. In the framework of the dislocation model, the instability of the plastic flow is shown to be caused by the relay mechanism of overcoming barriers
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d86ad215db425f98c48910891f20c5e
https://doi.org/10.1007/978-3-030-54928-2_31
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8
Molecular chaperone RAP interacts with LRP1 in a dynamic bivalent mode and enhances folding of ligand-binding regions of other LDLR family receptors
Autor: Svetlana A Shestopal, Andrey G Sarafanov, Ekaterina S. Marakasova, James H. Kurasawa, Haarin Chun, Elena Karnaukhova, Dudley K. Strickland, Nancy E. Hernandez, Philip Olivares, Gabriela U. Hassink
Publikováno v: The Journal of Biological Chemistry
The low-density lipoprotein receptor (LDLR) family of receptors are cell-surface receptors that internalize numerous ligands and play crucial role in various processes, such as lipoprotein metabolism, hemostasis, fetal development, etc. Previously, r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdca564b873d705b6974821f416bc0a1
https://doi.org/10.1016/j.jbc.2021.100842
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9
Expression and characterization of a codon‐optimized blood coagulation factor VIII
Autor: Jian-Jiang Hao, John H. McVey, Yideng Liang, James H. Kurasawa, Mikhail V Ovanesov, Elena Karnaukhova, Timothy K Lee, M. Lin, Andrey G Sarafanov, Svetlana A Shestopal
Publikováno v: Journal of Thrombosis and Haemostasis. 15:709-720
Essentials Recombinant factor VIII (FVIII) is known to be expressed at a low level in cell culture. To increase expression, we used codon-optimization of a B-domain deleted FVIII (BDD-FVIII). This resulted in 7-fold increase of the expression level i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b64994cd77134f5a7ed53cb239a293
https://doi.org/10.1111/jth.13632
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10
Characterization of Protein Unable to Bind Von Willebrand Factor in Recombinant Factor VIII Products: Can We Reduce Their Immunogenicity?
Autor: Mikhail V Ovanesov, John R Pettersson, Rong-Fong Shen, Timothy K Lee, Svetlana A Shestopal, Andrey G Sarafanov, Philip Olivares, Wells W. Wu, Haarin Chun, Stepan S Surov, Ekaterina S. Marakasova
Publikováno v: Blood. 136:25-26
Introduction Therapeutic products with blood coagulation factor VIII (FVIII) have a wide range of protein contents per activity unit (or IU/mg, specific activity), available from previous studies (Lin et al, 2004; Butenas et al, 2009) and the prescri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccec7b8838b1c123f87f761be9ce5186
https://doi.org/10.1182/blood-2020-133286
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