Zobrazeno 1 - 10
of 80
pro vyhledávání: '"A G, Papageorge"'
Autor:
Brajendra K. Tripathi, Meghan F. Anderman, Disha Bhargava, Luciarita Boccuzzi, Xiaolan Qian, Dunrui Wang, Marian E. Durkin, Alex G. Papageorge, Fernando J. de Miguel, Katerina Politi, Kylie J. Walters, James H. Doroshow, Douglas R. Lowy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The tumor suppressor gene DLC1 can be downregulated in cancers through genetic and non-genetic mechanisms. Here, the authors show cytoplasmic EZH2 can directly methylate and destabilize the DLC1 protein, and EZH2 inhibition can increase the DLC1 prot
Externí odkaz:
https://doaj.org/article/7176f11d2bb2458e8f04d65843a147be
Autor:
Adam J. Bass, Channing J. Der, Douglas R. Lowy, Adrienne D. Cox, Emanuel F. Petricoin, Kwok-Kin Wong, George Church, Timothy C. Wang, Katherine A. Hoadley, Mariaelena Pierobon, Sarah Derks, Leonie K. de Klerk, Fahire G. Akarca, Zhong Wu, Jin Zhou, Jennifer Liao, Matthew D. Stachler, Alex G. Papageorge, J. Nathaniel Diehl, Devon R. Blake, Richard G. Hodge, Yichen Wang, Antje Schaefer, Haisheng Zhang
Diffuse gastric cancer (DGC) is a lethal malignancy lacking effective systemic therapy. Among the most provocative recent results in DGC has been that of highly recurrent missense mutations in the GTPase RHOA. The function of these mutations has rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a2062b37221a584c9e0557e87fe2a8e
https://doi.org/10.1158/2159-8290.c.6547882.v1
https://doi.org/10.1158/2159-8290.c.6547882.v1
Autor:
Adam J. Bass, Channing J. Der, Douglas R. Lowy, Adrienne D. Cox, Emanuel F. Petricoin, Kwok-Kin Wong, George Church, Timothy C. Wang, Katherine A. Hoadley, Mariaelena Pierobon, Sarah Derks, Leonie K. de Klerk, Fahire G. Akarca, Zhong Wu, Jin Zhou, Jennifer Liao, Matthew D. Stachler, Alex G. Papageorge, J. Nathaniel Diehl, Devon R. Blake, Richard G. Hodge, Yichen Wang, Antje Schaefer, Haisheng Zhang
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32cf2b19817995da9a9a75ad73aa191b
https://doi.org/10.1158/2159-8290.22535578
https://doi.org/10.1158/2159-8290.22535578
Autor:
Adam J. Bass, Channing J. Der, Douglas R. Lowy, Adrienne D. Cox, Emanuel F. Petricoin, Kwok-Kin Wong, George Church, Timothy C. Wang, Katherine A. Hoadley, Mariaelena Pierobon, Sarah Derks, Leonie K. de Klerk, Fahire G. Akarca, Zhong Wu, Jin Zhou, Jennifer Liao, Matthew D. Stachler, Alex G. Papageorge, J. Nathaniel Diehl, Devon R. Blake, Richard G. Hodge, Yichen Wang, Antje Schaefer, Haisheng Zhang
List of Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32eefeff46aef947cd43c914935d6ac
https://doi.org/10.1158/2159-8290.22535575
https://doi.org/10.1158/2159-8290.22535575
Autor:
Adam J. Bass, Channing J. Der, Douglas R. Lowy, Adrienne D. Cox, Emanuel F. Petricoin, Kwok-Kin Wong, George Church, Timothy C. Wang, Katherine A. Hoadley, Mariaelena Pierobon, Sarah Derks, Leonie K. de Klerk, Fahire G. Akarca, Zhong Wu, Jin Zhou, Jennifer Liao, Matthew D. Stachler, Alex G. Papageorge, J. Nathaniel Diehl, Devon R. Blake, Richard G. Hodge, Yichen Wang, Antje Schaefer, Haisheng Zhang
Supplementary Video S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593f9baaa0b2cdf971f6b99af39b1142
https://doi.org/10.1158/2159-8290.22535554.v1
https://doi.org/10.1158/2159-8290.22535554.v1
Autor:
Adam J. Bass, Channing J. Der, Douglas R. Lowy, Adrienne D. Cox, Emanuel F. Petricoin, Kwok-Kin Wong, George Church, Timothy C. Wang, Katherine A. Hoadley, Mariaelena Pierobon, Sarah Derks, Leonie K. de Klerk, Fahire G. Akarca, Zhong Wu, Jin Zhou, Jennifer Liao, Matthew D. Stachler, Alex G. Papageorge, J. Nathaniel Diehl, Devon R. Blake, Richard G. Hodge, Yichen Wang, Antje Schaefer, Haisheng Zhang
Supplementary Figures and Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e810e7c390d32bad4be2d052c43dbf2
https://doi.org/10.1158/2159-8290.22535581.v1
https://doi.org/10.1158/2159-8290.22535581.v1
Autor:
Brajendra Tripathi, Nicole Hirsh, David Hansen, Xiaolan Qian, Dunrui Wang, Marian E. Durkin, Ashley Lim, Alex G. Papageorge, Suresh S. Ramalingham, Adam I. Marcus, Douglas R. Lowy
Publikováno v:
Cancer Research. 83:1727-1727
The DLC1 tumor suppressor gene encodes a cytoplasmic RHO-GAP protein whose expression is frequently decreased in many cancer types, especially lung cancer. We have identified several cancer-associated post-translational modifications in the DLC1 prot
Autor:
Katerina Politi, Disha Bhargava, Brajendra K. Tripathi, Meghan F. Anderman, Douglas R. Lowy, Alex G. Papageorge, Luciarita Boccuzzi, Xiaolan Qian, Dunrui Wang, Marian E. Durkin, James H. Doroshow, Fernando J. de Miguel, Kylie J. Walters
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
mRNA expression of the DLC1 tumor suppressor gene is downregulated in many lung cancers and their derived cell lines, with DLC1 protein levels being low or absent. Although the role of increased EZH2 methyltransferase in cancer is usually attributed
Autor:
Devon R. Blake, Channing J. Der, Fahire G Akarca, Jennifer Liao, Yichen Wang, Leonie K. de Klerk, Adam J. Bass, Kwok-Kin Wong, Mariaelena Pierobon, Richard G. Hodge, Douglas R. Lowy, Alex G. Papageorge, Adrienne D. Cox, Matthew D. Stachler, Emanuel F. Petricoin, J. Nathaniel Diehl, George M. Church, Antje Schaefer, Timothy C. Wang, Sarah Derks, Jin Zhou, Haisheng Zhang, Katherine A. Hoadley, Zhong Wu
Publikováno v:
Zhang, H, Schaefer, A, Wang, Y, Hodge, R G, Blake, D R, Diehl, J N, Papageorge, A G, Stachler, M D, Liao, J, Zhou, J, Wu, Z, Akarca, F G, de Klerk, L K, Derks, S, Pierobon, M, Hoadley, K A, Wang, T C, Church, G, Wong, K K, Petricoin, E F, Cox, A D, Lowy, D R, Der, C J & Bass, A J 2020, ' Gain-of-function RHOA mutations promote focal adhesion kinase activation and dependency in diffuse gastric cancer ', Cancer discovery, vol. 10, no. 2, pp. 288-305 . https://doi.org/10.1158/2159-8290.CD-19-0811
Cancer discovery, vol 10, iss 2
Cancer discovery, 10(2), 288-305. American Association for Cancer Research Inc.
Cancer discovery, vol 10, iss 2
Cancer discovery, 10(2), 288-305. American Association for Cancer Research Inc.
Diffuse gastric cancer (DGC) is a lethal malignancy lacking effective systemic therapy. Among the most provocative recent results in DGC has been that of highly recurrent missense mutations in the GTPase RHOA. The function of these mutations has rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d819637c93bcdc9e4a28baa8548de68
Autor:
Nigel P S Crawford, Xiaolan Qian, Argyrios Ziogas, Alex G Papageorge, Brenda J Boersma, Renard C Walker, Luanne Lukes, William L Rowe, Jinghui Zhang, Stefan Ambs, Douglas R Lowy, Hoda Anton-Culver, Kent W Hunter
Publikováno v:
PLoS Genetics, Vol 3, Iss 11, p e214 (2007)
A novel candidate metastasis modifier, ribosomal RNA processing 1 homolog B (Rrp1b), was identified through two independent approaches. First, yeast two-hybrid, immunoprecipitation, and functional assays demonstrated a physical and functional interac
Externí odkaz:
https://doaj.org/article/024d35a8a3384db88bf5b2ceca00f697