Zobrazeno 1 - 10
of 120
pro vyhledávání: '"A G, Demaine"'
Autor:
Patricia Balaresque, Georgina R Bowden, Susan M Adams, Ho-Yee Leung, Turi E King, Zoë H Rosser, Jane Goodwin, Jean-Paul Moisan, Christelle Richard, Ann Millward, Andrew G Demaine, Guido Barbujani, Carlo Previderè, Ian J Wilson, Chris Tyler-Smith, Mark A Jobling
Publikováno v:
PLoS Biology, Vol 8, Iss 1, p e1000285 (2010)
The relative contributions to modern European populations of Paleolithic hunter-gatherers and Neolithic farmers from the Near East have been intensely debated. Haplogroup R1b1b2 (R-M269) is the commonest European Y-chromosomal lineage, increasing in
Externí odkaz:
https://doaj.org/article/19f7fca69e5141dfabba525748e440e9
Publikováno v:
Journal of Endocrinology and Diabetes. 3:1-7
Autor:
Steve Shaw, Andrea Hodgkinson, Annwyne Houldsworth, Magdalena Metzner, E. R. Kaminski, Matthew E. Cramp, Andy G. Demaine
Publikováno v:
Journal of Medical Virology. 87:1207-1217
HCV is a major cause of liver disease worldwide. IL-12 plays an essential role in the balance of T helper 1 (Th1) differentiation versus a T helper 2 (Th2) driven response from its naive precursor. Linkage disequilibrium measures the degree to which
Autor:
Annwyne Houldsworth, Andy G. Demaine, E Kaminski, Magdalena Metzner, Steve Shaw, Matthew E. Cramp
Publikováno v:
Journal of Medical Virology. 86:941-947
Hepatitis C virus (HCV) is a pathogen causing chronic hepatitis, cirrhosis, and liver cancer occurring in about 3% of the world's population. Most individuals infected with HCV develop persistent viremia. Oxidative stress may play an important role i
Autor:
Matthew E. Cramp, Annwyne Houldsworth, Andrea Hodgkinson, Andrew G. Demaine, E. R. Kaminski, Magdalena Metzner
Publikováno v:
Journal of Medical Virology. 86:162-168
Several cell surface molecules have hepatitis C virus (HCV) binding properties and may serve as receptors facilitating viral entry into cells. The large extracellular loop (LEL) of CD81 has been shown to bind the HCV envelope protein E2 with several
Publikováno v:
Transplant Immunology. 25:16-19
Reactive oxygen species (ROS) such as superoxide (O(2)(-)) play important roles in inflammatory processes. By altering the redox environment, ROS modulate the activation of transcription factors and cytokine genes involved in acute cellular rejection
Publikováno v:
International Journal of Diabetes Mellitus. 2(3):169-174
Aims To investigate whether high glucose induces myo-inositol oxygenase (MIOX) expression in peripheral blood mononuclear cells through transcription factors, nuclear factor of activated T cells 5 (NFAT5) and carbohydrate response element binding pro
Publikováno v:
Journal of Interferon & Cytokine Research. 30:59-66
Type 1 diabetes is an autoimmune disease that is caused by destruction of pancreatic beta-cells. Type 1 diabetes is a heterogenic disease with environmental factors as well as genetic components. It is well established that environmental factors can
Autor:
PH Thurairajah, E. R. Kaminski, Nikolai V. Naoumov, Doha Hegazy, Shilpa Chokshi, Andrew G. Demaine, Matthew E. Cramp, Steve Shaw
Publikováno v:
The Journal of Infectious Diseases. 198:1749-1755
Background. Injection drug users (IDUs) are at risk of acquiring hepatitis C virus (HCV) infection. We have identified a cohort of long-term IDUs who remain uninfected by HCV despite high-risk behavior. We have categorized these subjects as “expose
Autor:
Michael J. McMahon, Derek A. O'Reilly, Michael Larvin, Mark T Cartmell, Andrew N. Kingsnorth, Andrew G. Demaine, Sakhawat H. Rahman, Andreas Kage, Michael Becker, Olfert Landt, Kevin Sargen, Heiko Witt, Hans-Ulrich Schulz
Publikováno v:
European Journal of Gastroenterology & Hepatology. 20:726-731
Acute pancreatitis (AP) is a disease whose pathogenesis remains largely obscure. Genetic research has focussed attention upon the role of the pancreatic protease/protease inhibitor system. The aim of this study was to investigate the prevalence of ge