Zobrazeno 1 - 4
of 4
pro vyhledávání: '"A Fern Barrington"'
Autor:
Jennifer A. Hurcombe, Fern Barrington, Micol Marchetti, Virginie M.S. Betin, Emily E. Bowen, Abigail C. Lay, Lan Ni, Lusyan Dayalan, Robert J.P. Pope, Paul T. Brinkkoetter, Martin Holzenberger, Gavin I. Welsh, Richard J.M. Coward
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109749- (2024)
Summary: Insulin signaling to the glomerular podocyte via the insulin receptor (IR) is critical for kidney function. In this study we show that near-complete knockout of the closely related insulin-like growth factor 1 receptor (IGF1R) in podocytes i
Externí odkaz:
https://doaj.org/article/961bd36ce95841e4b8f27817b6223d15
Autor:
Robert G. Nelson, Matthias Kretzler, Abigail C Lay, Viji Nair, Christopher R. Neal, Gavin I. Welsh, Jenny A Hurcombe, Marieangela C. Wilson, Raina D. Ramnath, Philip A. Lewis, A Fern Barrington, Kate J. Heesom, Wenjun Ju, Matthew J. Butler, Craig A. McArdle, Mark A. Graham, Denize Atan, Rebecca M. Perrett, Edward Mountjoy, Richard J M Coward, Simon C. Satchell, Eleanor Herbert
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Lay, A C, Barrington, A F, Hurcombe, J A, Ramnath, R D, Graham, M, Lewis, P A, Wilson, M C, Heesom, K J, Butler, M J, Perrett, R M, Neal, C R, Herbert, E, Mountjoy, E, Atan, D, Nair, V, Ju, W, Nelson, R G, Kretzler, M, Satchell, S C, McArdle, C A, Welsh, G I & Coward, R J M 2020, ' A role for NPY-NPY2R signaling in albuminuric kidney disease ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 27, 202004651, pp. 15862-15873 . https://doi.org/10.1073/pnas.2004651117
Lay, A C, Barrington, A F, Hurcombe, J A, Ramnath, R D, Graham, M, Lewis, P A, Wilson, M C, Heesom, K J, Butler, M J, Perrett, R M, Neal, C R, Herbert, E, Mountjoy, E, Atan, D, Nair, V, Ju, W, Nelson, R G, Kretzler, M, Satchell, S C, McArdle, C A, Welsh, G I & Coward, R J M 2020, ' A role for NPY-NPY2R signaling in albuminuric kidney disease ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 27, 202004651, pp. 15862-15873 . https://doi.org/10.1073/pnas.2004651117
Significance Neuropeptide Y (NPY) is implicated in many pathological conditions including obesity, diabetes, and insulin resistance. However, a pathogenic role of NPY in kidney disease has not been described. We found that NPY is produced by the podo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7cd8936d1a4b3df29684254bf4466ee
http://europepmc.org/articles/PMC7355002
http://europepmc.org/articles/PMC7355002
Autor:
Lan Ni, Ruth Rollason, Richard J M Coward, Gavin I. Welsh, Abigail C Lay, Mette Viberg Østergaard, Grace Pearson, Hellyeh Hamidi, Virginie M S Betin, Lawrence Gillam, Jenny A Hurcombe, Rachel Lennon, Fern Barrington
Publikováno v:
Diabetologia
Lay, A C, Hurcombe, J A, Betin, V M S, Barrington, F, Rollason, R, Ni, L, Gillam, L, Pearson, G M E, Østergaard, M V, Hamidi, H, Lennon, R, Welsh, G I & Coward, R J M 2017, ' Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor ', Diabetologia, vol. 60, no. 11, pp. 2299-2311 . https://doi.org/10.1007/s00125-017-4394-0
Lay, A C, Hurcombe, J, Betin, V, Barrington, F, Rollason, R, Ni, L, Gillam, L, Pearson, G M E, Østergaard, M V, Hamidi, H, Lennon, R, Welsh, G & Coward, R 2017, ' Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor ', Diabetologia . https://doi.org/10.1007/s00125-017-4394-0
Lay, A C, Hurcombe, J A, Betin, V M S, Barrington, F, Rollason, R, Ni, L, Gillam, L, Pearson, G M E, Østergaard, M V, Hamidi, H, Lennon, R, Welsh, G I & Coward, R J M 2017, ' Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor ', Diabetologia, vol. 60, no. 11, pp. 2299-2311 . https://doi.org/10.1007/s00125-017-4394-0
Lay, A C, Hurcombe, J, Betin, V, Barrington, F, Rollason, R, Ni, L, Gillam, L, Pearson, G M E, Østergaard, M V, Hamidi, H, Lennon, R, Welsh, G & Coward, R 2017, ' Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor ', Diabetologia . https://doi.org/10.1007/s00125-017-4394-0
Aims/hypothesis Podocytes are insulin-responsive cells of the glomerular filtration barrier and are key in preventing albuminuria, a hallmark feature of diabetic nephropathy. While there is evidence that a loss of insulin signalling to podocytes is d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43a82ee33f1779b55144842053d13ef
Autor:
Christopher D. Buckley, Eric J. Jenkinson, Mohammad Z. Mustafa, Tie Zheng Hou, Graham Anderson, Sarah J. Flavell, David R. Withers, Peter J. L. Lane, Fern Barrington
Publikováno v:
European journal of immunology. 40(2)
Lymphoid tissue inducer cells (LTi) play an important role in the development of lymphoid tissue in embryos. Adult CD4(+)CD3(-) LTi-like cells present a similar phenotype and gene expression to their embryonic counterpart and have important roles in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a1f68a73797d1f852bfe9644bdfbff
https://pubmed.ncbi.nlm.nih.gov/19950181
https://pubmed.ncbi.nlm.nih.gov/19950181